Mg2+ Regulates Cytotoxic Functions of NK and CD8 T Cells in Chronic EBV Infection Through NKG2D
Chaigne-Delalande B, Li FY, O’Connor G, Lukacs MJ, Jiang P, Zheng L, Shatzer A, Biancalana M, Pittaluga S, Matthews HF, Jancel TJ, Bleesing JJ, Marsh RA, Kuijpers TW, Nichols KE, Lucas CL, Nagpal S, Mehmet H, Su HC, Cohen JI, Uzel G, Lenardo MJ. Mg2+ Regulates Cytotoxic Functions of NK and CD8 T Cells in Chronic EBV Infection Through NKG2D. Science 2013, 341: 186-191. PMID: 23846901, PMCID: PMC3894782, DOI: 10.1126/science.1240094.Peer-Reviewed Original ResearchMeSH KeywordsCation Transport ProteinsCD8-Positive T-LymphocytesCytotoxicity, ImmunologicEpstein-Barr Virus InfectionsHumansKiller Cells, NaturalMagnesiumMagnesium DeficiencyNK Cell Lectin-Like Receptor Subfamily KX-Linked Combined Immunodeficiency DiseasesConceptsEpstein-Barr virusNatural killerMagnesium transporter 1T cellsChronic EBV infectionCD8 T cellsIntracellular free magnesium concentrationEBV infectionCytolytic responsesCytotoxic functionReceptor NKG2DMagnesium supplementationBasal intracellularAntiviral immunityCytolytic activityFree magnesium concentrationNKG2DTransporter 1Genetic deficiencyDefective expressionCritical regulatorMagnesium concentrationKillerCellsIntracellular