Featured Publications
The role of PI3Kγ in the immune system: new insights and translational implications
Lanahan SM, Wymann MP, Lucas CL. The role of PI3Kγ in the immune system: new insights and translational implications. Nature Reviews Immunology 2022, 22: 687-700. PMID: 35322259, PMCID: PMC9922156, DOI: 10.1038/s41577-022-00701-8.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsClass Ib Phosphatidylinositol 3-KinaseHumansMacrophagesMicePhosphatidylinositol 3-KinasePhosphatidylinositol 3-KinasesPhosphoinositide-3 Kinase InhibitorsConceptsProtein structure determinationContext-dependent modulatorNew insightsImmune systemMonogenic immune disordersSpecific PI3Kγ inhibitorInflammatory cytokine releaseRole of PI3KγPI3Kγ deficiencyImmunomodulatory roleCytokine releaseClinical trialsImmune disordersPI3KγTherapeutic targetOncology indicationsTranslational implicationsDrug developmentStructure determinationPI3Kγ inhibitorsRecent advancesPhosphoinositideRoleHumansInsights
2023
PI3Kδ Pathway Dysregulation and Unique Features of Its Inhibition by Leniolisib in Activated PI3Kδ Syndrome and Beyond
Cant A, Chandra A, Munro E, Rao V, Lucas C. PI3Kδ Pathway Dysregulation and Unique Features of Its Inhibition by Leniolisib in Activated PI3Kδ Syndrome and Beyond. The Journal Of Allergy And Clinical Immunology In Practice 2023, 12: 69-78. PMID: 37777067, PMCID: PMC10872751, DOI: 10.1016/j.jaip.2023.09.016.Peer-Reviewed Original ResearchMeSH KeywordsClass I Phosphatidylinositol 3-KinasesHumansPhosphatidylinositol 3-KinasePhosphatidylinositol 3-KinasesPyrimidinesConceptsPI3Kδ inhibitorsActivated PI3Kδ SyndromeImmune cell developmentPI3Kδ syndromeSpecific inhibitory propertiesAdverse eventsTreatment optionsPI3Kδ activityHematological malignanciesPathway dysregulationInborn errorsDrug mechanismsGenetic hyperactivationLeniolisibSyndromeΔ isoformsCell developmentInhibitorsInhibitory propertiesΓ isoformsColitisNeutropeniaTolerabilityMalignancyHepatotoxicity