2024
Trainees’ perspectives on sickle cell education: a qualitative needs assessment
Prince E, Feder K, Calhoun C, Lee A, Carroll C, Restrepo V, Van Doren L. Trainees’ perspectives on sickle cell education: a qualitative needs assessment. BMC Medical Education 2024, 24: 715. PMID: 38956512, PMCID: PMC11220977, DOI: 10.1186/s12909-024-05696-5.Peer-Reviewed Original ResearchConceptsNeeds assessmentPatient care challengesIterative thematic analysisQualitative needs assessmentCost of careComplications of SCDBackgroundSickle cell diseaseCare challengesHealthcare biasesSpecific educationThematic analysisMedical traineesFocus groupsClinical careTrainees' attitudesQualitative interviewsLack of national standardsLongitudinal exposureClinical teachingUnited StatesExpert cliniciansSubspecialty trainingTraineesCareHealthcarePerspectives of Adolescents and Young Adults With Sickle Cell Disease and Clinicians on Improving Transition Readiness With a Video Game Intervention
Aronson P, Nolan S, Schaeffer P, Hieftje K, Ponce K, Calhoun C. Perspectives of Adolescents and Young Adults With Sickle Cell Disease and Clinicians on Improving Transition Readiness With a Video Game Intervention. Journal Of Pediatric Hematology/Oncology 2024, 46: e147-e155. PMID: 38237001, DOI: 10.1097/mph.0000000000002810.Peer-Reviewed Original ResearchConceptsVideo game interventionPediatric to adult careOptimize self-efficacyGame interventionPatient engagementSelf-efficacyAdult careIdentified 4 main themesMedical decisionsImprove transition readinessYoung adultsExperiences of cliniciansQuaternary-care hospitalSickle cell diseaseData saturationTransition readinessMultilevel determinantsSemistructured interviewsClinician experienceHome managementCareInductive analysisCell diseaseDecision-makingIntervention
2023
Trainees' Perspectives on Components of Sickle Cell Specific Education
Van Doren L, Feder K, Calhoun C, Carroll C, Prince E. Trainees' Perspectives on Components of Sickle Cell Specific Education. Blood 2023, 142: 791. DOI: 10.1182/blood-2023-180303.Peer-Reviewed Original ResearchSickle cell disease educationPrevalence of sickle cell diseaseSpecific educationExposure to patientsFocus groupsTrainees' perspectivesSickle cell diseaseSurvey developmentFocus group guideLack of clinician knowledgeCare of personsFocus group transcriptsEvidence-based practiceMedically complex diseasesEvidenced-based guidelinesSense of masterySickle cell disease programBackground Sickle cell diseaseIncreasing trainee knowledgeSpecific curriculumComplex diseasesTime-sensitive needsDifficulty caringQualitative research studySex-matched personsPerspectives of Adolescents and Young Adults with Sickle Cell Disease and Clinicians on Improving Transition Readiness and a Videogame Intervention
Aronson P, Nolan S, Schaeffer P, Hieftje K, Ponce K, Calhoun C. Perspectives of Adolescents and Young Adults with Sickle Cell Disease and Clinicians on Improving Transition Readiness and a Videogame Intervention. Blood 2023, 142: 5116. DOI: 10.1182/blood-2023-173310.Peer-Reviewed Original ResearchAdult careSickle cell diseaseTransition readinessPatient engagementClinician experienceVideogame interventionCell diseaseMedical decisionsYoung adultsDisease-specific knowledgeQuaternary care hospitalYoung SCD patientsSuccessful home managementHigh rateParents/caregiversPain crisisCare hospitalPatient factorsSuccessful disease managementHealthcare utilizationSCD patientsClinical manifestationsEmergency departmentProvider judgmentClinician's perspectiveStandardized Clinical Pathways Improve Management of Vaso-Occlusive Episodes in the Pediatric Emergency Department
Forward J, Thomas D, O'Malley S, Berkwitt A, Calhoun C, Krishnamurti L, Pashankar F. Standardized Clinical Pathways Improve Management of Vaso-Occlusive Episodes in the Pediatric Emergency Department. Blood 2023, 142: 2315. DOI: 10.1182/blood-2023-181285.Peer-Reviewed Original ResearchVaso-occlusive episodesSickle cell diseasePediatric emergency departmentMinutes of arrivalPain managementEmergency departmentClinical pathwayIntranasal fentanylYears post implementationHydromorphone PCAPain medicationPediatric patientsJune 30 thPain medication administrationVaso-occlusive painPercent of patientsPercentage of patientsQuality improvement projectOutcome one yearElectronic medical recordsPost implementationHealth care systemFirst analgesicED visitsED encountersAllotransplantation and Gene Therapy Equity for Children with Sickle Cell Disease: Distributional Cost-Effectiveness of Allotransplantation Vs Gene Therapy Vs Standard-of-Care in Pediatric Patients with Sickle Cell Disease in the United States
Goshua G, Ito S, Chetlapalli K, Potnis K, Calhoun C, Krishnamurti L, Krumholz H, Pandya A. Allotransplantation and Gene Therapy Equity for Children with Sickle Cell Disease: Distributional Cost-Effectiveness of Allotransplantation Vs Gene Therapy Vs Standard-of-Care in Pediatric Patients with Sickle Cell Disease in the United States. Blood 2023, 142: 490. DOI: 10.1182/blood-2023-191072.Peer-Reviewed Original ResearchSickle cell diseaseIncremental cost-effectiveness ratioDistributional cost-effectiveness analysisPediatric patientsCell diseaseCost-effectiveness analysisDisease severityHealth resource utilization dataPediatric Health Information SystemGene therapyJustifiable treatment optionTransplant-related mortalityVaso-occlusive crisisExpert clinical experienceMarrow Transplant ResearchSubstantial mortality riskVisual analog scaleQuality-adjusted life expectancyConcomitant riskCost-effectiveness ratioResource utilization dataCost-effectiveness frontierHost diseaseMaximum patientsOpioid therapyInfluence of participant and reviewer characteristics in application scores for a hematology research training program
Vesely S, King A, Vettese E, Heller J, Cuker A, Calhoun C, Stock W, Homer M, Fritz J, Sung L. Influence of participant and reviewer characteristics in application scores for a hematology research training program. Blood Advances 2023, 7: 4064-4071. PMID: 36939221, PMCID: PMC10388723, DOI: 10.1182/bloodadvances.2023009792.Peer-Reviewed Original ResearchThe Bias Time Out: A practical tool for advancing DEIB in the healthcare space
Calder G, Boyd C, Calhoun C, Capozzalo G, Pollart S. The Bias Time Out: A practical tool for advancing DEIB in the healthcare space. 2023 DOI: 10.69554/wymn2230.Peer-Reviewed Original ResearchDistributional Cost-Effectiveness of Equity-Enhancing Gene Therapy in Sickle Cell Disease in the United States.
Goshua G, Calhoun C, Ito S, James L, Luviano A, Krishnamurti L, Pandya A. Distributional Cost-Effectiveness of Equity-Enhancing Gene Therapy in Sickle Cell Disease in the United States. Annals Of Internal Medicine 2023, 176: 779-787. PMID: 37247420, PMCID: PMC10370480, DOI: 10.7326/m22-3272.Peer-Reviewed Original ResearchExamining Mental Health, Education, Employment, and Pain in Sickle Cell Disease
Harris K, Preiss L, Varughese T, Bauer A, Calhoun C, Treadwell M, Masese R, Hankins J, Hussain F, Glassberg J, Melvin C, Gibson R, King A. Examining Mental Health, Education, Employment, and Pain in Sickle Cell Disease. JAMA Network Open 2023, 6: e2314070. PMID: 37200033, PMCID: PMC10196879, DOI: 10.1001/jamanetworkopen.2023.14070.Peer-Reviewed Original ResearchConceptsSickle cell diseasePain frequencyMedical record abstractionPain severityMental healthHydroxyurea usePain medicationRecord abstractionCell diseaseMAIN OUTCOMEAdult Sickle Cell QualityElectronic medical record abstractionSickle Cell Disease Implementation ConsortiumDaily pain medicationHigher pain frequencySeverity of painRegular blood transfusionsMental health diagnosesPatient registry dataCross-sectional analysisAssociation of educationEmployment statusPain episodesPain reductionPain scoresHealth literacy correlates with abbreviated full‐scale IQ in adolescent and young adults with sickle cell disease
Bhatt N, Calhoun C, Longoria J, Nwosu C, Howell K, Varughese T, Kang G, Jacola L, Hankins J, King A. Health literacy correlates with abbreviated full‐scale IQ in adolescent and young adults with sickle cell disease. Pediatric Blood & Cancer 2023, 70: e30281. PMID: 36861391, PMCID: PMC10425156, DOI: 10.1002/pbc.30281.Peer-Reviewed Original ResearchConceptsSickle cell diseaseFull-scale intelligence quotientAdequate health literacyHealth literacyCell diseaseNeurocognitive deficitsInadequate health literacyLow health literacyCross-sectional studyDevelopment of interventionsChronic conditionsAdult careHigh school educationSign toolHealth outcomesYounger ageLogistic regressionAge 15Young adultsYoung adulthoodHealthcare decisionsAYAsIntelligence quotientWechsler Abbreviated ScaleDisease
2022
Gene Therapy Equity in Sickle Cell Disease: Distributional Cost-Effectiveness Analysis (DCEA) of Gene Therapy Vs. Standard-of-Care in Patients with Sickle Cell Disease in the United States
Goshua G, Calhoun C, Cheng V, James L, Luviano A, Krishnamurti L, Pandya A. Gene Therapy Equity in Sickle Cell Disease: Distributional Cost-Effectiveness Analysis (DCEA) of Gene Therapy Vs. Standard-of-Care in Patients with Sickle Cell Disease in the United States. Blood 2022, 140: 1395-1396. DOI: 10.1182/blood-2022-157460.Peer-Reviewed Original ResearchDecreased Resiliency Associated with Increased Hospitalizations for Children with Sickle Cell Disease (S535)
Zavadil J, Carpenter B, Calhoun C. Decreased Resiliency Associated with Increased Hospitalizations for Children with Sickle Cell Disease (S535). Journal Of Pain And Symptom Management 2022, 63: 924-925. DOI: 10.1016/j.jpainsymman.2022.02.158.Peer-Reviewed Original ResearchSickle cell disease managementCD-RISCParental resilienceFrequency of hospitalizationSources of stressPSS-10Resilience of childrenConnor-Davidson Resilience ScaleSickle cell diseasePSS-10 scoreChildren's resiliencePerceived Stress ScaleCD-RISC scoreEmergency room visitsHistory of strokeDepression ScalePsychosocial factorsChild healthChronic illnessPerceived stressStress ScaleResilience scoresCOVID pandemicResilience ScaleImprove resilience
2021
Transition for Adolescents and Young Adults With Sickle Cell Disease in a US Midwest Urban Center: A Multilevel Perspective on Barriers, Facilitators, and Future Directions
Calhoun C, Luo L, Baumann AA, Bauer A, Shen E, McKay V, Hooley C, James A, King AA. Transition for Adolescents and Young Adults With Sickle Cell Disease in a US Midwest Urban Center: A Multilevel Perspective on Barriers, Facilitators, and Future Directions. Journal Of Pediatric Hematology/Oncology 2021, 44: e872-e880. PMID: 35731941, PMCID: PMC9218344, DOI: 10.1097/mph.0000000000002322.Peer-Reviewed Original ResearchConceptsSickle cell diseaseAdult careCell diseaseSCD providersInherited red blood cell disorderIntervention characteristicsYoung adultsDomains of CFIRRed blood cell disordersEmergency department providersBlood cell disordersPain controlImplementation science frameworkLarge hospital systemHigh morbidityAdult clinicEmergency departmentSpecialized careCell disordersMultilevel barriersPatient experienceOuter settingInner settingHealth disparitiesConsolidated FrameworkSelf-reported positive impact of mentored clinical research training is associated with academic success in hematology
King AA, Vesely SK, Dadzie G, Calhoun C, Cuker A, Stock W, Walker A, Fritz J, Sung L. Self-reported positive impact of mentored clinical research training is associated with academic success in hematology. Blood Advances 2021, 5: 2919-2924. PMID: 34309634, PMCID: PMC8341353, DOI: 10.1182/bloodadvances.2021004421.Peer-Reviewed Original ResearchEngaging Caregivers and Providers of Children With Sickle Cell Anemia in Shared Decision Making for Hydroxyurea: Protocol for a Multicenter Randomized Controlled Trial
Hood AM, Strong H, Nwankwo C, Johnson Y, Peugh J, Mara CA, Shook LM, Brinkman WB, Real FJ, Klein MD, Hackworth R, Badawy SM, Thompson AA, Raphael JL, Yates AM, Smith-Whitley K, King AA, Calhoun C, Creary SE, Piccone CM, Hildenbrand AK, Reader SK, Neumayr L, Meier ER, Sobota AE, Rana S, Britto M, Saving KL, Treadwell M, Quinn CT, Ware RE, Crosby LE. Engaging Caregivers and Providers of Children With Sickle Cell Anemia in Shared Decision Making for Hydroxyurea: Protocol for a Multicenter Randomized Controlled Trial. JMIR Research Protocols 2021, 10: e27650. PMID: 34018965, PMCID: PMC8178738, DOI: 10.2196/27650.Peer-Reviewed Original ResearchSickle cell anemiaINTERNATIONAL REGISTERED REPORT IDENTIFIERHospital Medical CenterCell anemiaCincinnati Children's Hospital Medical CenterOnly disease-modifying treatmentHigher health care utilizationPotential long-term side effectsChildren's Hospital Medical CenterLong-term side effectsDisease-modifying treatmentsCaregivers of patientsHealth care utilizationEvidence-based guidelinesSerious medical complicationsResultant health outcomesSickle cell diseaseLife-threatening diseaseQuality of careHigh-quality careGenetic blood disorderProviders of childrenEarly morbidityControlled TrialsMedical complications
2020
Addressing Recruitment Challenges in the Engage-HU Trial in Young Children with Sickle Cell Disease
Hood A, Strong H, Nwankwo C, Johnson Y, Mara C, Shook L, Brinkman W, Real F, Klein M, King A, Calhoun C, Smith-Whitley K, Creary S, Britto M, Saving K, Piccone C, Raphael J, Volanakis E, Hildenbrand A, Reader S, Rana S, Neumayr L, Yates A, Badawy S, Thompson A, Sobota A, Meier E, Quinn C, Crosby L. Addressing Recruitment Challenges in the Engage-HU Trial in Young Children with Sickle Cell Disease. Blood 2020, 136: 26-27. DOI: 10.1182/blood-2020-141471.Peer-Reviewed Original ResearchSickle cell diseaseSite principal investigatorsNational HeartCell diseaseCaregivers' perceptionsBluebird BioAdvisory CommitteeYoung childrenPrincipal investigatorBlood Institute guidelinesPatient-centered outcomesChild health outcomesRandomized control trialStepped-wedge designMonths of ageCurrent equity holderMistrust of researchStudy's principal investigatorNeurologic morbidityPrimary endpointTreat principleBlood InstituteFuture trialsIntervention trialsSCD populationIntentional and unintentional nonadherence to hydroxyurea among people with sickle cell disease: a qualitative study
Hodges JR, Phillips SM, Norell S, Nwosu C, Khan H, Luo L, Badawy SM, King A, Tanabe P, Treadwell M, Rojas Smith L, Calhoun C, Hankins JS, Porter J. Intentional and unintentional nonadherence to hydroxyurea among people with sickle cell disease: a qualitative study. Blood Advances 2020, 4: 4463-4473. PMID: 32941646, PMCID: PMC7509876, DOI: 10.1182/bloodadvances.2020001701.Peer-Reviewed Original ResearchConceptsSickle cell diseaseSickle Cell Disease Implementation ConsortiumAdherence barriersCell diseaseMedication adherence barriersHealth care providersNonadherence factorsHydroxyurea therapyPatient adherenceUnintentional nonadherenceSCD populationCare providersEfficacious treatmentPatient choiceClinical discussionAge 15NonadherenceHydroxyureaDiseaseAdherenceQualitative studyParticipantsSemi-structured interviewsMedicationsRegimensIntegration of Mobile Health Into Sickle Cell Disease Care to Increase Hydroxyurea Utilization: Protocol for an Efficacy and Implementation Study
Hankins JS, Shah N, DiMartino L, Brambilla D, Fernandez ME, Gibson RW, Gordeuk VR, Lottenberg R, Kutlar A, Melvin C, Simon J, Wun T, Treadwell M, Calhoun C, Baumann A, Potter MB, Klesges L, Bosworth H, . Integration of Mobile Health Into Sickle Cell Disease Care to Increase Hydroxyurea Utilization: Protocol for an Efficacy and Implementation Study. JMIR Research Protocols 2020, 9: e16319. PMID: 32442144, PMCID: PMC7388044, DOI: 10.2196/16319.Peer-Reviewed Original ResearchSickle Cell Disease Implementation ConsortiumSickle cell diseaseINTERNATIONAL REGISTERED REPORT IDENTIFIERMHealth interventionsDisease complicationsSickle cell disease careAcute disease complicationsImplementation-effectiveness studyNational Health LungHealth-related qualityEvidence-based guidelinesProportion of daysHealth appsHealth LungHydroxyurea useHydroxyurea therapyAppropriate prescribingMedication adherenceDisease careChronic diseasesMobile health appsCell diseasePrescribing behaviorHealth literacyPatientsPerceptions of US Adolescents and Adults With Sickle Cell Disease on Their Quality of Care
Kanter J, Gibson R, Lawrence RH, Smeltzer MP, Pugh NL, Glassberg J, Masese RV, King AA, Calhoun C, Hankins JS, Treadwell M. Perceptions of US Adolescents and Adults With Sickle Cell Disease on Their Quality of Care. JAMA Network Open 2020, 3: e206016. PMID: 32469413, PMCID: PMC7260622, DOI: 10.1001/jamanetworkopen.2020.6016.Peer-Reviewed Original ResearchConceptsSickle cell diseaseSickle Cell Disease Implementation ConsortiumCell diseaseInherited red blood cell disorderResponse rateQuality careAdequate quality carePerception of outpatientsUsual care cliniciansUsual care physiciansEmergency department careAcute care settingRed blood cell disordersHealth careMedical care experienceWorse health outcomesQuality of careMultiple health disparitiesBlood cell disordersQuality health careED satisfactionAcute painED visitsSevere painYounger patients