1994
Low-dose indomethacin therapy and extension of intraventricular hemorrhage: A multicenter randomized trial
Ment L, Oh W, Ehrenkranz R, Phillip A, Vohr B, Allan W, Makuch R, Taylor K, Schneider K, Katz K, Scott D, Duncan C. Low-dose indomethacin therapy and extension of intraventricular hemorrhage: A multicenter randomized trial. The Journal Of Pediatrics 1994, 124: 951-955. PMID: 8201485, DOI: 10.1016/s0022-3476(05)83191-9.Peer-Reviewed Original ResearchConceptsLow-grade intraventricular hemorrhageIntraventricular hemorrhageAdverse eventsBirth weightLow birth weight infantsDistribution of hemorrhageGrade intraventricular hemorrhageBirth weight infantsPlacebo-controlled trialPercentage of infantsPatent ductus arteriosusGm birth weightHours of ageIndomethacin therapyWeight infantsApgar scoreParenchymal involvementSaline placeboDuctus arteriosusGestational ageIntracranial hemorrhagePostnatal hoursCascade of eventsPatent ductusCranial sonogramsLow-dose indomethacin and prevention of intraventricular hemorrhage: a multicenter randomized trial.
Ment L, Ehrenkranz R, Duncan C, Scott D, Taylor K, Katz K, Schneider K, Makuch R, Oh W, Vohr B, Philip A, Allan W. Low-dose indomethacin and prevention of intraventricular hemorrhage: a multicenter randomized trial. Pediatrics 1994, 93: 543-50. PMID: 8134206, DOI: 10.1542/peds.93.4.543.Peer-Reviewed Original ResearchConceptsLow birth weight neonatesSeverity of IVHBirth weight neonatesIntraventricular hemorrhageWeight neonatesDose indomethacinBirth weightGrade 4 intraventricular hemorrhageSerial cranial ultrasound examinationsSignificant adverse drug eventsPercent of neonatesPlacebo-controlled trialPatent ductus arteriosusCranial ultrasound examinationMajor risk factorAdverse drug eventsHours of ageFirst postnatal dayDuctal closureProphylactic indomethacinApgar scoreNeurodevelopmental handicapParenchymal involvementPlacebo groupAdverse events
1988
Randomized low-dose indomethacin trial for prevention of intraventricular hemorrhage in very low birth weight neonates
Ment L, Duncan C, Ehrenkranz R, Kleinman C, Taylor K, Scott D, Gettner P, Sherwonit E, Williams J. Randomized low-dose indomethacin trial for prevention of intraventricular hemorrhage in very low birth weight neonates. The Journal Of Pediatrics 1988, 112: 948-955. PMID: 3373405, DOI: 10.1016/s0022-3476(88)80225-7.Peer-Reviewed Original ResearchConceptsIntraventricular hemorrhageGerminal matrixPostnatal hoursUrinary outputDay 5Placebo-controlled prospective trialLow birth weight neonatesDuctus arteriosus shuntIndomethacin-treated infantsSerum indomethacin levelsBirth weight neonatesCardiac ultrasound studiesAdequate urinary outputGroups of infantsIndomethacin trialStudy medicationApgar scorePreterm neonatesProspective trialWeight neonatesDuctus arteriosusGestational ageSerum electrolytesBirth weightPatent ductus
1985
Randomized indomethacin trial for prevention of intraventricular hemorrhage in very low birth weight infants
Ment L, Duncan C, Ehrenkranz R, Kleinman C, Pitt B, Taylor J, Scott D, Stewart W, Gettner P. Randomized indomethacin trial for prevention of intraventricular hemorrhage in very low birth weight infants. The Journal Of Pediatrics 1985, 107: 937-943. PMID: 3906073, DOI: 10.1016/s0022-3476(85)80197-9.Peer-Reviewed Original ResearchConceptsNeonatal intraventricular hemorrhageIntraventricular hemorrhagePostnatal hoursDuctus arteriosusLow birth weight infantsIndomethacin-treated groupIndomethacin-treated infantsPlacebo-treated patientsBirth weight infantsInitiation of therapyPatent ductus arteriosusCardiac ultrasound studiesIndomethacin trialApgar scoreWeight infantsPreterm neonatesControl infantsGestational ageOverall incidenceCerebral microvasculatureSerum electrolytesUrinary outputBirth weightClotting functionsUltrasound study