1989
Beagle puppy model of perinatal asphyxia: Blockade of excitatory neurotransmitters
Ment L, Stewart W, Petroff O, Duncan C, Montoya D. Beagle puppy model of perinatal asphyxia: Blockade of excitatory neurotransmitters. Pediatric Neurology 1989, 5: 281-286. PMID: 2553028, DOI: 10.1016/0887-8994(89)90018-0.Peer-Reviewed Original ResearchConceptsN-methyl-D-aspartate receptor antagonist MK801Cerebral blood flowBlood flowPerinatal asphyxiaCerebral high-energy phosphatesN-methyl-D-aspartate receptorsSaline 15 minBeagle puppy modelModel of ischemiaNewborn beagle puppiesHigh-energy phosphatesNeuropathologic damageAsphyxial insultPuppy modelNeuronal changesCerebral lactateExcitatory neurotransmitterBrainstem structuresPhosphocreatine levelsDrug treatmentMetabolic insultsBeagle puppiesMK801InsultPuppies
1988
Beagle puppy model of perinatal asphyxia: Alterations in cerebral blood flow and metabolism
Ment L, Stewart W, Gore J, Duncan C. Beagle puppy model of perinatal asphyxia: Alterations in cerebral blood flow and metabolism. Pediatric Neurology 1988, 4: 98-104. PMID: 3149477, DOI: 10.1016/0887-8994(88)90048-3.Peer-Reviewed Original ResearchConceptsCerebral blood flowBeagle puppy modelPerinatal asphyxiaPuppy modelBlood flowControl of CBFUncoupling of CBFATP/Pi ratioBaseline 1 hourRadioactive microsphere determinationsPCr/PiWhite matter regionsDays of ageAsphyxial episodesAsphyxial insultNeurodevelopmental handicapArterial pressureClinical sequelaeElectrocerebral silenceMicrosphere determinationBrainstem structuresCBF dataBaseline valuesPathologic conditionsAsphyxia
1987
Beagle pup model of brain injury: regional cerebral blood flow and cerebral prostaglandins.
Ment L, Stewart W, Duncan C, Pitt B, Cole J. Beagle pup model of brain injury: regional cerebral blood flow and cerebral prostaglandins. Journal Of Neurosurgery 1987, 67: 278-83. PMID: 3598687, DOI: 10.3171/jns.1987.67.2.0278.Peer-Reviewed Original ResearchConceptsRegional cerebral blood flowCerebral blood flowAsphyxial insultBrain injuryBlood flowSevere asphyxial insultPeriventricular white matterSevere brain injuryRole of prostaglandinsEffects of asphyxiaNewborn beagle pupsCerebral prostaglandinsVentilatory supportNeuropathological changesPGE2 levelsCommon causeBeagle pupsWhite matterAutoradiographic determinationInsultPupsAsphyxiaYoung childrenSeparate groupsSignificant increase