1987
Beagle pup model of brain injury: regional cerebral blood flow and cerebral prostaglandins.
Ment L, Stewart W, Duncan C, Pitt B, Cole J. Beagle pup model of brain injury: regional cerebral blood flow and cerebral prostaglandins. Journal Of Neurosurgery 1987, 67: 278-83. PMID: 3598687, DOI: 10.3171/jns.1987.67.2.0278.Peer-Reviewed Original ResearchConceptsRegional cerebral blood flowCerebral blood flowAsphyxial insultBrain injuryBlood flowSevere asphyxial insultPeriventricular white matterSevere brain injuryRole of prostaglandinsEffects of asphyxiaNewborn beagle pupsCerebral prostaglandinsVentilatory supportNeuropathological changesPGE2 levelsCommon causeBeagle pupsWhite matterAutoradiographic determinationInsultPupsAsphyxiaYoung childrenSeparate groupsSignificant increase
1986
Beagle puppy model of perinatal cerebral insults. Cerebral blood flow changes and intraventricular hemorrhage evoked by hypoxemia.
Ment L, Stewart W, Duncan C, Pitt B. Beagle puppy model of perinatal cerebral insults. Cerebral blood flow changes and intraventricular hemorrhage evoked by hypoxemia. Journal Of Neurosurgery 1986, 65: 847-50. PMID: 3772483, DOI: 10.3171/jns.1986.65.6.0847.Peer-Reviewed Original ResearchConceptsCerebral blood flowWhite matterIntraventricular hemorrhageRegional cerebral blood flowCerebral blood flow changesNeonatal cerebral infarctionPerinatal cerebral insultsParieto-occipital white matterEffects of hypoxemiaBeagle puppy modelNewborn beagle pupsBlood flow changesTemporal white matterParietal white matterCentral gray regionNeuropathological injuryCerebral infarctionPerinatal asphyxiaCerebral insultNeuropathological changesPuppy modelCommon causeGerminal matrixBeagle pupsBlood flow
1985
Beagle puppy model of perinatal cerebral infarction. Acute changes in regional cerebral prostaglandins during hemorrhagic hypotension.
Ment L, Stewart W, Duncan C, Cole J, Pitt B. Beagle puppy model of perinatal cerebral infarction. Acute changes in regional cerebral prostaglandins during hemorrhagic hypotension. Journal Of Neurosurgery 1985, 63: 899-904. PMID: 4056903, DOI: 10.3171/jns.1985.63.6.0899.Peer-Reviewed Original ResearchConceptsPerinatal cerebral infarctionPeriventricular white matterNewborn beagle pupsHemorrhagic hypotensionWhite matterCerebral infarctionNeuropathological changesThromboxane B2Beagle pupsMean arterial blood pressureSlow venous hemorrhagePeriventricular white matter regionsArterial blood pressureProstaglandin E2 levelsEffects of hypotensionCerebral blood flowProstaglandin determinationsBeagle puppy modelStable breakdown productWhite matter regionsCerebral prostaglandinsBlood pressureIntensive carePuppy modelPGF1 alpha1691 ASSOCIATION OF CEREBRAL PROSTAGLANDIN IMBALANCE WITH PERINMAL STROKE
Ment L, Duncan C, Stewart W, Pitt B, Cole J, Pearson H. 1691 ASSOCIATION OF CEREBRAL PROSTAGLANDIN IMBALANCE WITH PERINMAL STROKE. Pediatric Research 1985, 19: 392-392. DOI: 10.1203/00006450-198504000-01715.Peer-Reviewed Original ResearchCerebral blood flowNewborn beagle pupsCerebral infarctionBeagle pupsBlood flowPGI2/TXA2 balanceNeonatal cerebral infarctionSlow venous hemorrhageStable breakdown productPerinatal ischemiaNeuropathological consequencesProstaglandin levelsCommon causeVenous hemorrhageHH groupSimilar insultsStable metaboliteEffects of HhPG levelsC groupInsultPupsInfarctionMABPHgBeagle puppy model of intraventricular hemorrhage. Effect of superoxide dismutase on cerebral blood flow and prostaglandins.
Ment L, Stewart W, Duncan C. Beagle puppy model of intraventricular hemorrhage. Effect of superoxide dismutase on cerebral blood flow and prostaglandins. Journal Of Neurosurgery 1985, 62: 563-9. PMID: 3973726, DOI: 10.3171/jns.1985.62.4.0563.Peer-Reviewed Original ResearchConceptsCerebral blood flowIntraventricular hemorrhageProstaglandin levelsBlood flowSuperoxide dismutaseCarbon-14-iodoantipyrine autoradiographyIncidence of IVHSystemic blood pressure changesBaseline cerebral blood flowLocal cerebral blood flowDetermination of CBFBlood pressure changesSaline-pretreated animalsBeagle puppy modelNewborn beagle pupsGerminal matrix tissueHypotensive insultFree radical scavengerPreterm neonatesIodoantipyrine autoradiographyPuppy modelBeagle pupsCapillary morphologyInsultHemorrhage
1984
PROSTAGLANDIN-MEDIATED CONTROL OF NEONATAL CEREBRAL BLOOD FLOW
Ment L, Stewart W, Duncan C, Pitt B. PROSTAGLANDIN-MEDIATED CONTROL OF NEONATAL CEREBRAL BLOOD FLOW. Pediatric Research 1984, 18: 380-380. DOI: 10.1203/00006450-198404001-01722.Peer-Reviewed Original ResearchCerebral blood flowNeonatal cerebral blood flowIntraventricular hemorrhageNewborn beagle pupsBP changesCBF changesBeagle pupsBlood flowSuperoxide dismutaseBaseline cerebral blood flowNeonatal intraventricular hemorrhageCyclo-oxygenase pathwaySynthesis of TxB2Free radical scavengerPreterm neonatesHemorrhagic hypotensionCapillary changesIndomethacinPupsSynthetic enzymesAlterationsBreakdown productsHypotensionHemorrhageNeonates
1983
Beagle puppy model of intraventricular hemorrhage. Effect of indomethacin on cerebral blood flow.
Ment L, Stewart W, Duncan C, Scott D, Lambrecht R. Beagle puppy model of intraventricular hemorrhage. Effect of indomethacin on cerebral blood flow. Journal Of Neurosurgery 1983, 58: 857-62. PMID: 6854378, DOI: 10.3171/jns.1983.58.6.0857.Peer-Reviewed Original ResearchConceptsCerebral blood flowIntraventricular hemorrhageNewborn beagle puppiesBeagle puppiesBlood flowDetermination of CBFBlood pressure responseNeonatal intraventricular hemorrhageEffect of indomethacinBeagle puppy modelNewborn beagle pupsPuppy modelBeagle pupsIndomethacinProstaglandin synthetaseInsultPupsFormer groupSignificant alterationsPressure responseHemorrhagePuppiesSalineGroup