2000
Outcome of Children in the Indomethacin Intraventricular Hemorrhage Prevention Trial
Ment L, Vohr B, Allan W, Westerveld M, Sparrow S, Schneider K, Katz K, Duncan C, Makuch R. Outcome of Children in the Indomethacin Intraventricular Hemorrhage Prevention Trial. Pediatrics 2000, 105: 485-491. PMID: 10699097, DOI: 10.1542/peds.105.3.485.Peer-Reviewed Original ResearchMeSH KeywordsAnti-Inflammatory Agents, Non-SteroidalBrain Damage, ChronicCerebral HemorrhageCerebral VentriclesChild, PreschoolDose-Response Relationship, DrugFemaleFollow-Up StudiesHumansIndomethacinInfantInfant, NewbornInfant, Premature, DiseasesMaleNeurologic ExaminationNeuropsychological TestsPregnancyConceptsLow-dose indomethacinIntraventricular hemorrhagePlacebo childrenIndomethacin therapyPreterm infantsEarly administrationNeurologic examinationPrevention trialsLow birth weight preterm infantsStudy childrenBirth weight preterm infantsSeverity of IVHLow birth weight survivorsMean gestational ageWeight preterm infantsAdverse neurodevelopmental outcomesOutcome of childrenStandard neurologic examinationYears of ageNeurodevelopmental handicapPreterm neonatesNeurodevelopmental examinationNeurodevelopmental outcomesCerebral palsyGestational age
1993
Intraventricular Hemorrhage and Prematurity
Duncan C, Ment L. Intraventricular Hemorrhage and Prematurity. Neurosurgery Clinics Of North America 1993, 4: 727-734. PMID: 8241793, DOI: 10.1016/s1042-3680(18)30562-x.Peer-Reviewed Original ResearchConceptsIntraventricular hemorrhageRisk of hemorrhageCerebral blood flowGerminal matrix tissueDiagnostic imaging techniquesPosthemorrhagic hydrocephalusPreterm neonatesClinical manifestationsBlood flowVentricular systemHemorrhageCapillary bedMatrix tissueImaging techniquesPossible rupturePrematurityHydrocephalusNeonatesNeuropathologyParenchymaBrainRisk period for intraventricular hemorrhage of the preterm neonate is independent of gestational age.
Ment L, Oh W, Ehrenkranz R, Philip A, Schneider K, Katz K, Taylor K, Duncan C, Makuch R. Risk period for intraventricular hemorrhage of the preterm neonate is independent of gestational age. Seminars In Perinatology 1993, 17: 338-41. PMID: 8290976.Peer-Reviewed Original Research
1988
Randomized low-dose indomethacin trial for prevention of intraventricular hemorrhage in very low birth weight neonates
Ment L, Duncan C, Ehrenkranz R, Kleinman C, Taylor K, Scott D, Gettner P, Sherwonit E, Williams J. Randomized low-dose indomethacin trial for prevention of intraventricular hemorrhage in very low birth weight neonates. The Journal Of Pediatrics 1988, 112: 948-955. PMID: 3373405, DOI: 10.1016/s0022-3476(88)80225-7.Peer-Reviewed Original ResearchConceptsIntraventricular hemorrhageGerminal matrixPostnatal hoursUrinary outputDay 5Placebo-controlled prospective trialLow birth weight neonatesDuctus arteriosus shuntIndomethacin-treated infantsSerum indomethacin levelsBirth weight neonatesCardiac ultrasound studiesAdequate urinary outputGroups of infantsIndomethacin trialStudy medicationApgar scorePreterm neonatesProspective trialWeight neonatesDuctus arteriosusGestational ageSerum electrolytesBirth weightPatent ductus
1985
Randomized indomethacin trial for prevention of intraventricular hemorrhage in very low birth weight infants
Ment L, Duncan C, Ehrenkranz R, Kleinman C, Pitt B, Taylor J, Scott D, Stewart W, Gettner P. Randomized indomethacin trial for prevention of intraventricular hemorrhage in very low birth weight infants. The Journal Of Pediatrics 1985, 107: 937-943. PMID: 3906073, DOI: 10.1016/s0022-3476(85)80197-9.Peer-Reviewed Original ResearchConceptsNeonatal intraventricular hemorrhageIntraventricular hemorrhagePostnatal hoursDuctus arteriosusLow birth weight infantsIndomethacin-treated groupIndomethacin-treated infantsPlacebo-treated patientsBirth weight infantsInitiation of therapyPatent ductus arteriosusCardiac ultrasound studiesIndomethacin trialApgar scoreWeight infantsPreterm neonatesControl infantsGestational ageOverall incidenceCerebral microvasculatureSerum electrolytesUrinary outputBirth weightClotting functionsUltrasound studyEarly Childhood Developmental Follow-Up of Infants with GMH/IVH: Effect of Methylxanthine Therapy
Ment L, Scott D, Ehrenkranz R, Duncan C. Early Childhood Developmental Follow-Up of Infants with GMH/IVH: Effect of Methylxanthine Therapy. American Journal Of Perinatology 1985, 2: 223-227. PMID: 4015773, DOI: 10.1055/s-2007-999955.Peer-Reviewed Original ResearchConceptsGMH/IVHMethylxanthine therapyCerebral blood flowBlood flowSmall preterm neonatesBayley mental scoresIdiopathic apneaBirthweight neonatesPreterm neonatesIntraventricular hemorrhageNeurodevelopmental outcomesNeonatal periodMental scoresGerminal matrixTherapyIVHUnderlying disturbanceInfantsAdverse effectsFurther studiesNeonatesCognitive functioningHarmful effectsMetabolismApneaBeagle puppy model of intraventricular hemorrhage. Effect of superoxide dismutase on cerebral blood flow and prostaglandins.
Ment L, Stewart W, Duncan C. Beagle puppy model of intraventricular hemorrhage. Effect of superoxide dismutase on cerebral blood flow and prostaglandins. Journal Of Neurosurgery 1985, 62: 563-9. PMID: 3973726, DOI: 10.3171/jns.1985.62.4.0563.Peer-Reviewed Original ResearchConceptsCerebral blood flowIntraventricular hemorrhageProstaglandin levelsBlood flowSuperoxide dismutaseCarbon-14-iodoantipyrine autoradiographyIncidence of IVHSystemic blood pressure changesBaseline cerebral blood flowLocal cerebral blood flowDetermination of CBFBlood pressure changesSaline-pretreated animalsBeagle puppy modelNewborn beagle pupsGerminal matrix tissueHypotensive insultFree radical scavengerPreterm neonatesIodoantipyrine autoradiographyPuppy modelBeagle pupsCapillary morphologyInsultHemorrhage
1984
Perinatal cerebral infarction
Ment L, Duncan C, Ehrenkranz R. Perinatal cerebral infarction. Annals Of Neurology 1984, 16: 559-568. PMID: 6508239, DOI: 10.1002/ana.410160506.Peer-Reviewed Original ResearchConceptsPerinatal cerebral infarctionCerebral infarctionNeonatal intraventricular hemorrhageFull-term infantsMonths of ageTwelve-month intervalsPerinatal asphyxiaPreterm neonatesIntraventricular hemorrhageNeonatal seizuresTomographic scanCommon causePostmortem examinationInfarctionInfantsStrokeAsphyxiaHemorrhageNeonatesSeizuresUteroDiagnosisMonthsPROSTAGLANDIN-MEDIATED CONTROL OF NEONATAL CEREBRAL BLOOD FLOW
Ment L, Stewart W, Duncan C, Pitt B. PROSTAGLANDIN-MEDIATED CONTROL OF NEONATAL CEREBRAL BLOOD FLOW. Pediatric Research 1984, 18: 380-380. DOI: 10.1203/00006450-198404001-01722.Peer-Reviewed Original ResearchCerebral blood flowNeonatal cerebral blood flowIntraventricular hemorrhageNewborn beagle pupsBP changesCBF changesBeagle pupsBlood flowSuperoxide dismutaseBaseline cerebral blood flowNeonatal intraventricular hemorrhageCyclo-oxygenase pathwaySynthesis of TxB2Free radical scavengerPreterm neonatesHemorrhagic hypotensionCapillary changesIndomethacinPupsSynthetic enzymesAlterationsBreakdown productsHypotensionHemorrhageNeonatesIntraventricular hemorrhage in the preterm neonate: Timing and cerebral blood flow changes
Ment L, Duncan C, Ehrenkranz R, Lange R, Taylor K, Kleinman C, Scott D, Sivo J, Gettner P. Intraventricular hemorrhage in the preterm neonate: Timing and cerebral blood flow changes. The Journal Of Pediatrics 1984, 104: 419-425. PMID: 6707798, DOI: 10.1016/s0022-3476(84)81109-9.Peer-Reviewed Original ResearchConceptsGMH/IVHCerebral blood flowPostnatal hoursBlood flowEarly hemorrhagePreterm neonatesIntraventricular hemorrhageIVH groupUltrasound studyLow cerebral blood flowCerebral blood flow changesCerebral blood flow determinationsCranial ultrasound studiesHigh ventilator settingsCerebral blood flow valuesPatent ductus arteriosusBlood flow changesRisk factor analysisBlood flow determinationsBlood flow valuesTime of birthVigorous resuscitationNeonatal eventsDuctus arteriosusEchocardiographic study
1982
Neonates of less than or equal to 1,250 grams birth weight: prospective neurodevelopmental evaluation during the first year post-term.
Ment L, Scott D, Ehrenkranz R, Rothman S, Duncan C, Warshaw J. Neonates of less than or equal to 1,250 grams birth weight: prospective neurodevelopmental evaluation during the first year post-term. Pediatrics 1982, 70: 292-6. PMID: 7099799, DOI: 10.1542/peds.70.2.292.Peer-Reviewed Original ResearchConceptsNeonatal intensive careIntraventricular hemorrhagePreterm neonatesIntensive careBirth weightIncidence of IVHNewborn Special Care UnitSophisticated neonatal intensive careGm birth weightGrams birth weightIll preterm neonatesSpecial care unitsConsecutive preterm neonatesYears of lifeNeurodevelopmental handicapCare unitPostnatal hoursProspective studyNeurodevelopmental evaluationMotor handicapEarly identificationGreater riskNeonatesDelayed acquisitionDevelopmental problems