1989
Thromboxane synthesis inhibitor in a beagle pup model of perinatal asphyxia.
Ment L, Stewart W, Petroff O, Duncan C. Thromboxane synthesis inhibitor in a beagle pup model of perinatal asphyxia. Stroke 1989, 20: 809-814. PMID: 2728050, DOI: 10.1161/01.str.20.6.809.Peer-Reviewed Original ResearchConceptsCerebral blood flowThromboxane synthesis inhibitorBlood flowPerinatal asphyxiaSynthesis inhibitorCGS 13080Intraventricular hemorrhageLactate levelsCerebral regionsHigh incidenceMetabolic alterationsWhite matterLactate concentrationAsphyxiaBrain extractsInsultPhosphocreatine concentrationPupsSalineInhibitorsHemorrhageProstaglandinsMedulla
1987
Beagle pup model of brain injury: regional cerebral blood flow and cerebral prostaglandins.
Ment L, Stewart W, Duncan C, Pitt B, Cole J. Beagle pup model of brain injury: regional cerebral blood flow and cerebral prostaglandins. Journal Of Neurosurgery 1987, 67: 278-83. PMID: 3598687, DOI: 10.3171/jns.1987.67.2.0278.Peer-Reviewed Original ResearchConceptsRegional cerebral blood flowCerebral blood flowAsphyxial insultBrain injuryBlood flowSevere asphyxial insultPeriventricular white matterSevere brain injuryRole of prostaglandinsEffects of asphyxiaNewborn beagle pupsCerebral prostaglandinsVentilatory supportNeuropathological changesPGE2 levelsCommon causeBeagle pupsWhite matterAutoradiographic determinationInsultPupsAsphyxiaYoung childrenSeparate groupsSignificant increase
1985
1691 ASSOCIATION OF CEREBRAL PROSTAGLANDIN IMBALANCE WITH PERINMAL STROKE
Ment L, Duncan C, Stewart W, Pitt B, Cole J, Pearson H. 1691 ASSOCIATION OF CEREBRAL PROSTAGLANDIN IMBALANCE WITH PERINMAL STROKE. Pediatric Research 1985, 19: 392-392. DOI: 10.1203/00006450-198504000-01715.Peer-Reviewed Original ResearchCerebral blood flowNewborn beagle pupsCerebral infarctionBeagle pupsBlood flowPGI2/TXA2 balanceNeonatal cerebral infarctionSlow venous hemorrhageStable breakdown productPerinatal ischemiaNeuropathological consequencesProstaglandin levelsCommon causeVenous hemorrhageHH groupSimilar insultsStable metaboliteEffects of HhPG levelsC groupInsultPupsInfarctionMABPHg
1984
PROSTAGLANDIN-MEDIATED CONTROL OF NEONATAL CEREBRAL BLOOD FLOW
Ment L, Stewart W, Duncan C, Pitt B. PROSTAGLANDIN-MEDIATED CONTROL OF NEONATAL CEREBRAL BLOOD FLOW. Pediatric Research 1984, 18: 380-380. DOI: 10.1203/00006450-198404001-01722.Peer-Reviewed Original ResearchCerebral blood flowNeonatal cerebral blood flowIntraventricular hemorrhageNewborn beagle pupsBP changesCBF changesBeagle pupsBlood flowSuperoxide dismutaseBaseline cerebral blood flowNeonatal intraventricular hemorrhageCyclo-oxygenase pathwaySynthesis of TxB2Free radical scavengerPreterm neonatesHemorrhagic hypotensionCapillary changesIndomethacinPupsSynthetic enzymesAlterationsBreakdown productsHypotensionHemorrhageNeonatesBeagle puppy model of intraventricular hemorrhage. Effect of indomethacin on local cerebral glucose utilization.
Ment L, Stewart W, Duncan C, Scott D, Lambrecht R. Beagle puppy model of intraventricular hemorrhage. Effect of indomethacin on local cerebral glucose utilization. Journal Of Neurosurgery 1984, 60: 737-42. PMID: 6707743, DOI: 10.3171/jns.1984.60.4.0737.Peer-Reviewed Original ResearchConceptsLocal cerebral glucose utilizationCerebral glucose utilizationIntraventricular hemorrhageSaline-pretreated animalsNewborn beagle puppiesBeagle puppiesGlucose utilizationIncidence of IVHBlood pressure responseNeonatal intraventricular hemorrhageEffect of indomethacinBeagle puppy modelCerebral metabolismPuppy modelGerminal matrixWhite matterIndomethacinMarked alterationsInsultSignificant alterationsPressure responseHemorrhagePupsPuppiesAlterations
1983
Beagle puppy model of intraventricular hemorrhage. Effect of indomethacin on cerebral blood flow.
Ment L, Stewart W, Duncan C, Scott D, Lambrecht R. Beagle puppy model of intraventricular hemorrhage. Effect of indomethacin on cerebral blood flow. Journal Of Neurosurgery 1983, 58: 857-62. PMID: 6854378, DOI: 10.3171/jns.1983.58.6.0857.Peer-Reviewed Original ResearchConceptsCerebral blood flowIntraventricular hemorrhageNewborn beagle puppiesBeagle puppiesBlood flowDetermination of CBFBlood pressure responseNeonatal intraventricular hemorrhageEffect of indomethacinBeagle puppy modelNewborn beagle pupsPuppy modelBeagle pupsIndomethacinProstaglandin synthetaseInsultPupsFormer groupSignificant alterationsPressure responseHemorrhagePuppiesSalineGroup
1982
Local cerebral glucose utilization in the beagle puppy model of intraventricular hemorrhage.
Ment L, Stewart W, Duncan C. Local cerebral glucose utilization in the beagle puppy model of intraventricular hemorrhage. Journal Of Neurosurgery 1982, 57: 384-9. PMID: 7097335, DOI: 10.3171/jns.1982.57.3.0384.Peer-Reviewed Original ResearchConceptsLocal cerebral glucose utilizationCerebral glucose utilizationBeagle puppy modelIntraventricular hemorrhagePuppy modelGlucose utilizationCerebral blood flowAdult animal studiesWhite matter differentiationControl pupsBlood flowAnimal studiesNeuropathological conditionsBrain regionsHemorrhageMatter differentiationUptakePups