2000
Outcome of Children in the Indomethacin Intraventricular Hemorrhage Prevention Trial
Ment L, Vohr B, Allan W, Westerveld M, Sparrow S, Schneider K, Katz K, Duncan C, Makuch R. Outcome of Children in the Indomethacin Intraventricular Hemorrhage Prevention Trial. Pediatrics 2000, 105: 485-491. PMID: 10699097, DOI: 10.1542/peds.105.3.485.Peer-Reviewed Original ResearchMeSH KeywordsAnti-Inflammatory Agents, Non-SteroidalBrain Damage, ChronicCerebral HemorrhageCerebral VentriclesChild, PreschoolDose-Response Relationship, DrugFemaleFollow-Up StudiesHumansIndomethacinInfantInfant, NewbornInfant, Premature, DiseasesMaleNeurologic ExaminationNeuropsychological TestsPregnancyConceptsLow-dose indomethacinIntraventricular hemorrhagePlacebo childrenIndomethacin therapyPreterm infantsEarly administrationNeurologic examinationPrevention trialsLow birth weight preterm infantsStudy childrenBirth weight preterm infantsSeverity of IVHLow birth weight survivorsMean gestational ageWeight preterm infantsAdverse neurodevelopmental outcomesOutcome of childrenStandard neurologic examinationYears of ageNeurodevelopmental handicapPreterm neonatesNeurodevelopmental examinationNeurodevelopmental outcomesCerebral palsyGestational age
1996
Neurodevelopmental outcome at 36 months' corrected age of preterm infants in the Multicenter Indomethacin Intraventricular Hemorrhage Prevention Trial.
Ment L, Vohr B, Oh W, Scott D, Allan W, Westerveld M, Duncan C, Ehrenkranz R, Katz K, Schneider K, Makuch R. Neurodevelopmental outcome at 36 months' corrected age of preterm infants in the Multicenter Indomethacin Intraventricular Hemorrhage Prevention Trial. Pediatrics 1996, 98: 714-8. PMID: 8885951, DOI: 10.1542/peds.98.4.714.Peer-Reviewed Original ResearchMeSH KeywordsCerebral HemorrhageChi-Square DistributionChild DevelopmentChild, PreschoolCyclooxygenase InhibitorsHumansIndomethacinInfantInfant, NewbornInfant, PrematureInfant, Premature, DiseasesInfant, Very Low Birth WeightIntelligence TestsNeurologic ExaminationUltrasonography, Doppler, TranscranialConceptsLow-dose indomethacinMonths' corrected ageIntraventricular hemorrhageCorrected ageNeurodevelopmental followLong-term neurodevelopmental followLow birth weight infantsLow birth weight neonatesBirth weight infantsMean gestational ageBirth weight neonatesStandard neurologic examinationAdverse cognitive outcomesIncidence of deafnessDose indomethacinWeight infantsPreterm infantsProspective trialWeight neonatesCranial ultrasoundEarly administrationNeurodevelopmental outcomesNeurologic examinationCerebral palsyGestational age
1995
Antenatal steroids, delivery mode, and intraventricular hemorrhage in preterm infants
Ment L, Oh W, Ehrenkranz R, Philip A, Duncan C, Makuch R. Antenatal steroids, delivery mode, and intraventricular hemorrhage in preterm infants. American Journal Of Obstetrics And Gynecology 1995, 172: 795-800. PMID: 7892866, DOI: 10.1016/0002-9378(95)90001-2.Peer-Reviewed Original ResearchConceptsEarly intraventricular hemorrhageAntenatal steroidsIntraventricular hemorrhageCesarean sectionPreterm infantsAntenatal steroid treatmentCesarean section deliveryHours of lifeMore vaginal deliveriesDelivery modePostnatal indomethacinSection deliveryWeight infantsSteroid treatmentVaginal deliveryHemorrhageInfantsSteroidsIndependent roleHoursDeliveryMulticenterIndomethacinTrialsEchoencephalography
1994
Low-dose indomethacin therapy and extension of intraventricular hemorrhage: A multicenter randomized trial
Ment L, Oh W, Ehrenkranz R, Phillip A, Vohr B, Allan W, Makuch R, Taylor K, Schneider K, Katz K, Scott D, Duncan C. Low-dose indomethacin therapy and extension of intraventricular hemorrhage: A multicenter randomized trial. The Journal Of Pediatrics 1994, 124: 951-955. PMID: 8201485, DOI: 10.1016/s0022-3476(05)83191-9.Peer-Reviewed Original ResearchConceptsLow-grade intraventricular hemorrhageIntraventricular hemorrhageAdverse eventsBirth weightLow birth weight infantsDistribution of hemorrhageGrade intraventricular hemorrhageBirth weight infantsPlacebo-controlled trialPercentage of infantsPatent ductus arteriosusGm birth weightHours of ageIndomethacin therapyWeight infantsApgar scoreParenchymal involvementSaline placeboDuctus arteriosusGestational ageIntracranial hemorrhagePostnatal hoursCascade of eventsPatent ductusCranial sonogramsLow-dose indomethacin and prevention of intraventricular hemorrhage: a multicenter randomized trial.
Ment L, Ehrenkranz R, Duncan C, Scott D, Taylor K, Katz K, Schneider K, Makuch R, Oh W, Vohr B, Philip A, Allan W. Low-dose indomethacin and prevention of intraventricular hemorrhage: a multicenter randomized trial. Pediatrics 1994, 93: 543-50. PMID: 8134206, DOI: 10.1542/peds.93.4.543.Peer-Reviewed Original ResearchConceptsLow birth weight neonatesSeverity of IVHBirth weight neonatesIntraventricular hemorrhageWeight neonatesDose indomethacinBirth weightGrade 4 intraventricular hemorrhageSerial cranial ultrasound examinationsSignificant adverse drug eventsPercent of neonatesPlacebo-controlled trialPatent ductus arteriosusCranial ultrasound examinationMajor risk factorAdverse drug eventsHours of ageFirst postnatal dayDuctal closureProphylactic indomethacinApgar scoreNeurodevelopmental handicapParenchymal involvementPlacebo groupAdverse events
1993
Intraventricular Hemorrhage and Prematurity
Duncan C, Ment L. Intraventricular Hemorrhage and Prematurity. Neurosurgery Clinics Of North America 1993, 4: 727-734. PMID: 8241793, DOI: 10.1016/s1042-3680(18)30562-x.Peer-Reviewed Original ResearchConceptsIntraventricular hemorrhageRisk of hemorrhageCerebral blood flowGerminal matrix tissueDiagnostic imaging techniquesPosthemorrhagic hydrocephalusPreterm neonatesClinical manifestationsBlood flowVentricular systemHemorrhageCapillary bedMatrix tissueImaging techniquesPossible rupturePrematurityHydrocephalusNeonatesNeuropathologyParenchymaBrainRisk period for intraventricular hemorrhage of the preterm neonate is independent of gestational age.
Ment L, Oh W, Ehrenkranz R, Philip A, Schneider K, Katz K, Taylor K, Duncan C, Makuch R. Risk period for intraventricular hemorrhage of the preterm neonate is independent of gestational age. Seminars In Perinatology 1993, 17: 338-41. PMID: 8290976.Peer-Reviewed Original Research
1992
Risk factors for early intraventricular hemorrhage in low birth weight infants
Ment L, Oh W, Philip A, Ehrenkranz R, Duncan C, Allan W, Taylor K, Schneider K, Katz K, Makuch R. Risk factors for early intraventricular hemorrhage in low birth weight infants. The Journal Of Pediatrics 1992, 121: 776-783. PMID: 1432433, DOI: 10.1016/s0022-3476(05)81915-8.Peer-Reviewed Original ResearchConceptsGMH/IVHBirth weightRisk factorsIntraventricular hemorrhageLow birth weight infantsBirth weight infantsMaternal risk factorsGm birth weightMore vaginal deliveriesIndependent prognostic indicatorGerminal matrix hemorrhageHigh-grade hemorrhageRisk factor dataGroups of infantsMode of deliveryEarly intraventricular hemorrhagePrimary hospitalizationSevere IVHTocolytic useWeight infantsPreterm infantsVaginal deliveryVertex presentationGestational ageIVH group
1988
Intraventricular hemorrhage of the preterm neonate: prevention studies.
Ment L, Ehrenkranz R, Duncan C. Intraventricular hemorrhage of the preterm neonate: prevention studies. Seminars In Perinatology 1988, 12: 359-72. PMID: 3065945.Peer-Reviewed Original ResearchRandomized low-dose indomethacin trial for prevention of intraventricular hemorrhage in very low birth weight neonates
Ment L, Duncan C, Ehrenkranz R, Kleinman C, Taylor K, Scott D, Gettner P, Sherwonit E, Williams J. Randomized low-dose indomethacin trial for prevention of intraventricular hemorrhage in very low birth weight neonates. The Journal Of Pediatrics 1988, 112: 948-955. PMID: 3373405, DOI: 10.1016/s0022-3476(88)80225-7.Peer-Reviewed Original ResearchMeSH KeywordsCerebral HemorrhageDuctus Arteriosus, PatentFemaleHumansIndomethacinInfant, Low Birth WeightInfant, NewbornInfant, PrematureMaleUrologic DiseasesConceptsIntraventricular hemorrhageGerminal matrixPostnatal hoursUrinary outputDay 5Placebo-controlled prospective trialLow birth weight neonatesDuctus arteriosus shuntIndomethacin-treated infantsSerum indomethacin levelsBirth weight neonatesCardiac ultrasound studiesAdequate urinary outputGroups of infantsIndomethacin trialStudy medicationApgar scorePreterm neonatesProspective trialWeight neonatesDuctus arteriosusGestational ageSerum electrolytesBirth weightPatent ductus
1986
Beagle puppy model of perinatal cerebral insults. Cerebral blood flow changes and intraventricular hemorrhage evoked by hypoxemia.
Ment L, Stewart W, Duncan C, Pitt B. Beagle puppy model of perinatal cerebral insults. Cerebral blood flow changes and intraventricular hemorrhage evoked by hypoxemia. Journal Of Neurosurgery 1986, 65: 847-50. PMID: 3772483, DOI: 10.3171/jns.1986.65.6.0847.Peer-Reviewed Original ResearchConceptsCerebral blood flowWhite matterIntraventricular hemorrhageRegional cerebral blood flowCerebral blood flow changesNeonatal cerebral infarctionPerinatal cerebral insultsParieto-occipital white matterEffects of hypoxemiaBeagle puppy modelNewborn beagle pupsBlood flow changesTemporal white matterParietal white matterCentral gray regionNeuropathological injuryCerebral infarctionPerinatal asphyxiaCerebral insultNeuropathological changesPuppy modelCommon causeGerminal matrixBeagle pupsBlood flow
1985
Beagle puppy model of perinatal cerebral infarction. Acute changes in regional cerebral prostaglandins during hemorrhagic hypotension.
Ment L, Stewart W, Duncan C, Cole J, Pitt B. Beagle puppy model of perinatal cerebral infarction. Acute changes in regional cerebral prostaglandins during hemorrhagic hypotension. Journal Of Neurosurgery 1985, 63: 899-904. PMID: 4056903, DOI: 10.3171/jns.1985.63.6.0899.Peer-Reviewed Original ResearchConceptsPerinatal cerebral infarctionPeriventricular white matterNewborn beagle pupsHemorrhagic hypotensionWhite matterCerebral infarctionNeuropathological changesThromboxane B2Beagle pupsMean arterial blood pressureSlow venous hemorrhagePeriventricular white matter regionsArterial blood pressureProstaglandin E2 levelsEffects of hypotensionCerebral blood flowProstaglandin determinationsBeagle puppy modelStable breakdown productWhite matter regionsCerebral prostaglandinsBlood pressureIntensive carePuppy modelPGF1 alphaRandomized indomethacin trial for prevention of intraventricular hemorrhage in very low birth weight infants
Ment L, Duncan C, Ehrenkranz R, Kleinman C, Pitt B, Taylor J, Scott D, Stewart W, Gettner P. Randomized indomethacin trial for prevention of intraventricular hemorrhage in very low birth weight infants. The Journal Of Pediatrics 1985, 107: 937-943. PMID: 3906073, DOI: 10.1016/s0022-3476(85)80197-9.Peer-Reviewed Original ResearchConceptsNeonatal intraventricular hemorrhageIntraventricular hemorrhagePostnatal hoursDuctus arteriosusLow birth weight infantsIndomethacin-treated groupIndomethacin-treated infantsPlacebo-treated patientsBirth weight infantsInitiation of therapyPatent ductus arteriosusCardiac ultrasound studiesIndomethacin trialApgar scoreWeight infantsPreterm neonatesControl infantsGestational ageOverall incidenceCerebral microvasculatureSerum electrolytesUrinary outputBirth weightClotting functionsUltrasound studyIntraventricular hemorrhage in a term neonate secondary to a third ventricular AVM. Case report.
Heafner M, Duncan C, Kier E, Ment L, Scott D, Kolaski R, Sorgen C. Intraventricular hemorrhage in a term neonate secondary to a third ventricular AVM. Case report. Journal Of Neurosurgery 1985, 63: 640-3. PMID: 3875699, DOI: 10.3171/jns.1985.63.4.0640.Peer-Reviewed Original ResearchMeSH KeywordsCerebral HemorrhageCerebral VentriclesCerebral VentriculographyFemaleHumansInfant, NewbornIntracranial Arteriovenous MalformationsConceptsIntraventricular hemorrhageUncomplicated full-term gestationsFull-term neonatesFull-term gestationDays of lifeMonths of ageDigital subtraction arteriographyDays of ageAcute onsetPostoperative courseTerm neonatesHealthy infantsSeizure disorderArteriovenous malformationsDifferential diagnosisThird ventricleComputerized tomographyYoung infantsHemorrhageArteriographyAngiomaNeonatesInfantsDiagnosisAgeBeagle puppy model of perinatal cerebral infarction. Acute changes in cerebral blood flow and metabolism during hemorrhagic hypotension.
Ment L, Stewart W, Duncan C, Pitt B, Rescigno A, Cole J. Beagle puppy model of perinatal cerebral infarction. Acute changes in cerebral blood flow and metabolism during hemorrhagic hypotension. Journal Of Neurosurgery 1985, 63: 441-7. PMID: 3839525, DOI: 10.3171/jns.1985.63.3.0441.Peer-Reviewed Original ResearchConceptsLocal cerebral glucose utilizationCerebral blood flowRegional cerebral blood flowHypotensive insultCerebral infarctionHemorrhagic hypotensionBlood flowUncoupling of CBFMean arterial blood pressureNeonatal cerebral infarctionParieto-occipital white matterPerinatal cerebral infarctionSerum prostaglandin levelsSlow venous hemorrhagePeriventricular white matter regionsAutoradiographic determinationArterial blood pressureCerebral glucose utilizationProstaglandin E2 levelsEffects of hypotensionBeagle puppy modelNewborn beagle pupsGray matter structuresStable breakdown productWhite matter regionsEarly Childhood Developmental Follow-Up of Infants with GMH/IVH: Effect of Methylxanthine Therapy
Ment L, Scott D, Ehrenkranz R, Duncan C. Early Childhood Developmental Follow-Up of Infants with GMH/IVH: Effect of Methylxanthine Therapy. American Journal Of Perinatology 1985, 2: 223-227. PMID: 4015773, DOI: 10.1055/s-2007-999955.Peer-Reviewed Original ResearchConceptsGMH/IVHMethylxanthine therapyCerebral blood flowBlood flowSmall preterm neonatesBayley mental scoresIdiopathic apneaBirthweight neonatesPreterm neonatesIntraventricular hemorrhageNeurodevelopmental outcomesNeonatal periodMental scoresGerminal matrixTherapyIVHUnderlying disturbanceInfantsAdverse effectsFurther studiesNeonatesCognitive functioningHarmful effectsMetabolismApneaNeurodevelopmental assessment of very low birth weight neonates: Effect of germinal matrix and intraventricular hemorrhage
Ment L, Scott D, Ehrenkranz R, Duncan C. Neurodevelopmental assessment of very low birth weight neonates: Effect of germinal matrix and intraventricular hemorrhage. Pediatric Neurology 1985, 1: 164-168. PMID: 3880401, DOI: 10.1016/0887-8994(85)90058-x.Peer-Reviewed Original ResearchConceptsGMH/IVHIntraventricular hemorrhageNeurodevelopmental assessmentGerminal matrixSurviving infantsNeonatal germinal matrix hemorrhageNewborn Special Care UnitLow birth weight neonatesBirth weight neonatesGerminal matrix hemorrhageMajor neurologic abnormalitiesSpecial care unitsNon-hemorrhage groupWeight neonatesCare unitGroup infantsPostnatal hoursNeurologic abnormalitiesBirth weightSevere gradesHemorrhageDevelopmental scoresBayley ScalesInfantsInfant developmentBeagle puppy model of intraventricular hemorrhage. Effect of superoxide dismutase on cerebral blood flow and prostaglandins.
Ment L, Stewart W, Duncan C. Beagle puppy model of intraventricular hemorrhage. Effect of superoxide dismutase on cerebral blood flow and prostaglandins. Journal Of Neurosurgery 1985, 62: 563-9. PMID: 3973726, DOI: 10.3171/jns.1985.62.4.0563.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornCerebral HemorrhageCerebral VentriclesCerebrovascular CirculationDogsModels, BiologicalProstaglandinsSuperoxide DismutaseConceptsCerebral blood flowIntraventricular hemorrhageProstaglandin levelsBlood flowSuperoxide dismutaseCarbon-14-iodoantipyrine autoradiographyIncidence of IVHSystemic blood pressure changesBaseline cerebral blood flowLocal cerebral blood flowDetermination of CBFBlood pressure changesSaline-pretreated animalsBeagle puppy modelNewborn beagle pupsGerminal matrix tissueHypotensive insultFree radical scavengerPreterm neonatesIodoantipyrine autoradiographyPuppy modelBeagle pupsCapillary morphologyInsultHemorrhagePerinatal Cerebral Insults: Hemorrhage and Ischemia
Ment L, Duncan C, Stewart W. Perinatal Cerebral Insults: Hemorrhage and Ischemia. Pediatric Neurosurgery 1985, 12: 168-174. PMID: 3916368, DOI: 10.1159/000120242.Peer-Reviewed Original ResearchConceptsMajor neurodevelopmental handicapsCerebral blood flowNeurodevelopmental handicapParenchymal involvementCerebral infarctionPreterm infantsIntraventricular hemorrhageGestational ageIschemic insultPerinatal careHigh riskBlood flowHemorrhageInfantsDevelopmental abnormalitiesCareInfarctionIschemiaNeonatesLesionsAbnormalitiesIncidenceInsultSurvivorsBrain
1984
Perinatal cerebral infarction
Ment L, Duncan C, Ehrenkranz R. Perinatal cerebral infarction. Annals Of Neurology 1984, 16: 559-568. PMID: 6508239, DOI: 10.1002/ana.410160506.Peer-Reviewed Original ResearchConceptsPerinatal cerebral infarctionCerebral infarctionNeonatal intraventricular hemorrhageFull-term infantsMonths of ageTwelve-month intervalsPerinatal asphyxiaPreterm neonatesIntraventricular hemorrhageNeonatal seizuresTomographic scanCommon causePostmortem examinationInfarctionInfantsStrokeAsphyxiaHemorrhageNeonatesSeizuresUteroDiagnosisMonths