2000
Outcome of Children in the Indomethacin Intraventricular Hemorrhage Prevention Trial
Ment L, Vohr B, Allan W, Westerveld M, Sparrow S, Schneider K, Katz K, Duncan C, Makuch R. Outcome of Children in the Indomethacin Intraventricular Hemorrhage Prevention Trial. Pediatrics 2000, 105: 485-491. PMID: 10699097, DOI: 10.1542/peds.105.3.485.Peer-Reviewed Original ResearchMeSH KeywordsAnti-Inflammatory Agents, Non-SteroidalBrain Damage, ChronicCerebral HemorrhageCerebral VentriclesChild, PreschoolDose-Response Relationship, DrugFemaleFollow-Up StudiesHumansIndomethacinInfantInfant, NewbornInfant, Premature, DiseasesMaleNeurologic ExaminationNeuropsychological TestsPregnancyConceptsLow-dose indomethacinIntraventricular hemorrhagePlacebo childrenIndomethacin therapyPreterm infantsEarly administrationNeurologic examinationPrevention trialsLow birth weight preterm infantsStudy childrenBirth weight preterm infantsSeverity of IVHLow birth weight survivorsMean gestational ageWeight preterm infantsAdverse neurodevelopmental outcomesOutcome of childrenStandard neurologic examinationYears of ageNeurodevelopmental handicapPreterm neonatesNeurodevelopmental examinationNeurodevelopmental outcomesCerebral palsyGestational age
1996
Neurodevelopmental outcome at 36 months' corrected age of preterm infants in the Multicenter Indomethacin Intraventricular Hemorrhage Prevention Trial.
Ment L, Vohr B, Oh W, Scott D, Allan W, Westerveld M, Duncan C, Ehrenkranz R, Katz K, Schneider K, Makuch R. Neurodevelopmental outcome at 36 months' corrected age of preterm infants in the Multicenter Indomethacin Intraventricular Hemorrhage Prevention Trial. Pediatrics 1996, 98: 714-8. PMID: 8885951, DOI: 10.1542/peds.98.4.714.Peer-Reviewed Original ResearchMeSH KeywordsCerebral HemorrhageChi-Square DistributionChild DevelopmentChild, PreschoolCyclooxygenase InhibitorsHumansIndomethacinInfantInfant, NewbornInfant, PrematureInfant, Premature, DiseasesInfant, Very Low Birth WeightIntelligence TestsNeurologic ExaminationUltrasonography, Doppler, TranscranialConceptsLow-dose indomethacinMonths' corrected ageIntraventricular hemorrhageCorrected ageNeurodevelopmental followLong-term neurodevelopmental followLow birth weight infantsLow birth weight neonatesBirth weight infantsMean gestational ageBirth weight neonatesStandard neurologic examinationAdverse cognitive outcomesIncidence of deafnessDose indomethacinWeight infantsPreterm infantsProspective trialWeight neonatesCranial ultrasoundEarly administrationNeurodevelopmental outcomesNeurologic examinationCerebral palsyGestational age
1995
Antenatal steroids, delivery mode, and intraventricular hemorrhage in preterm infants
Ment L, Oh W, Ehrenkranz R, Philip A, Duncan C, Makuch R. Antenatal steroids, delivery mode, and intraventricular hemorrhage in preterm infants. American Journal Of Obstetrics And Gynecology 1995, 172: 795-800. PMID: 7892866, DOI: 10.1016/0002-9378(95)90001-2.Peer-Reviewed Original ResearchConceptsEarly intraventricular hemorrhageAntenatal steroidsIntraventricular hemorrhageCesarean sectionPreterm infantsAntenatal steroid treatmentCesarean section deliveryHours of lifeMore vaginal deliveriesDelivery modePostnatal indomethacinSection deliveryWeight infantsSteroid treatmentVaginal deliveryHemorrhageInfantsSteroidsIndependent roleHoursDeliveryMulticenterIndomethacinTrialsEchoencephalography
1994
Low-dose indomethacin therapy and extension of intraventricular hemorrhage: A multicenter randomized trial
Ment L, Oh W, Ehrenkranz R, Phillip A, Vohr B, Allan W, Makuch R, Taylor K, Schneider K, Katz K, Scott D, Duncan C. Low-dose indomethacin therapy and extension of intraventricular hemorrhage: A multicenter randomized trial. The Journal Of Pediatrics 1994, 124: 951-955. PMID: 8201485, DOI: 10.1016/s0022-3476(05)83191-9.Peer-Reviewed Original ResearchConceptsLow-grade intraventricular hemorrhageIntraventricular hemorrhageAdverse eventsBirth weightLow birth weight infantsDistribution of hemorrhageGrade intraventricular hemorrhageBirth weight infantsPlacebo-controlled trialPercentage of infantsPatent ductus arteriosusGm birth weightHours of ageIndomethacin therapyWeight infantsApgar scoreParenchymal involvementSaline placeboDuctus arteriosusGestational ageIntracranial hemorrhagePostnatal hoursCascade of eventsPatent ductusCranial sonograms
1993
Intraventricular Hemorrhage and Prematurity
Duncan C, Ment L. Intraventricular Hemorrhage and Prematurity. Neurosurgery Clinics Of North America 1993, 4: 727-734. PMID: 8241793, DOI: 10.1016/s1042-3680(18)30562-x.Peer-Reviewed Original ResearchConceptsIntraventricular hemorrhageRisk of hemorrhageCerebral blood flowGerminal matrix tissueDiagnostic imaging techniquesPosthemorrhagic hydrocephalusPreterm neonatesClinical manifestationsBlood flowVentricular systemHemorrhageCapillary bedMatrix tissueImaging techniquesPossible rupturePrematurityHydrocephalusNeonatesNeuropathologyParenchymaBrainRisk period for intraventricular hemorrhage of the preterm neonate is independent of gestational age.
Ment L, Oh W, Ehrenkranz R, Philip A, Schneider K, Katz K, Taylor K, Duncan C, Makuch R. Risk period for intraventricular hemorrhage of the preterm neonate is independent of gestational age. Seminars In Perinatology 1993, 17: 338-41. PMID: 8290976.Peer-Reviewed Original Research
1986
Bacterial meningitis as an etiology of perinatal cerebral infarction
Ment L, Ehrenkranz R, Duncan C. Bacterial meningitis as an etiology of perinatal cerebral infarction. Pediatric Neurology 1986, 2: 276-279. PMID: 3508700, DOI: 10.1016/0887-8994(86)90019-6.Peer-Reviewed Original ResearchMeSH KeywordsBacterial InfectionsCerebral InfarctionFollow-Up StudiesHumansInfant, NewbornInfant, Premature, DiseasesMeningitisRetrospective StudiesRisk FactorsTomography, X-Ray ComputedConceptsBacterial meningitisCerebral infarctionNewborn Special Care UnitPerinatal cerebral infarctionSpecial care unitsMonths of ageEarly intervention servicesNeurodevelopmental sequelaeNeuropathologic studiesCare unitTomographic scanSecondary edemaNeonatal scansSignificant incidenceMortality rateVascular distributionMeningitisInfarctionIntervention servicesSubsequent scansNeonatesTomographic studiesScansMonthsSignificant improvement
1985
Randomized indomethacin trial for prevention of intraventricular hemorrhage in very low birth weight infants
Ment L, Duncan C, Ehrenkranz R, Kleinman C, Pitt B, Taylor J, Scott D, Stewart W, Gettner P. Randomized indomethacin trial for prevention of intraventricular hemorrhage in very low birth weight infants. The Journal Of Pediatrics 1985, 107: 937-943. PMID: 3906073, DOI: 10.1016/s0022-3476(85)80197-9.Peer-Reviewed Original ResearchConceptsNeonatal intraventricular hemorrhageIntraventricular hemorrhagePostnatal hoursDuctus arteriosusLow birth weight infantsIndomethacin-treated groupIndomethacin-treated infantsPlacebo-treated patientsBirth weight infantsInitiation of therapyPatent ductus arteriosusCardiac ultrasound studiesIndomethacin trialApgar scoreWeight infantsPreterm neonatesControl infantsGestational ageOverall incidenceCerebral microvasculatureSerum electrolytesUrinary outputBirth weightClotting functionsUltrasound studyEarly Childhood Developmental Follow-Up of Infants with GMH/IVH: Effect of Methylxanthine Therapy
Ment L, Scott D, Ehrenkranz R, Duncan C. Early Childhood Developmental Follow-Up of Infants with GMH/IVH: Effect of Methylxanthine Therapy. American Journal Of Perinatology 1985, 2: 223-227. PMID: 4015773, DOI: 10.1055/s-2007-999955.Peer-Reviewed Original ResearchMeSH KeywordsApneaCerebral HemorrhageChild DevelopmentFemaleFollow-Up StudiesHumansInfantInfant, Low Birth WeightInfant, NewbornInfant, Premature, DiseasesMaleXanthinesConceptsGMH/IVHMethylxanthine therapyCerebral blood flowBlood flowSmall preterm neonatesBayley mental scoresIdiopathic apneaBirthweight neonatesPreterm neonatesIntraventricular hemorrhageNeurodevelopmental outcomesNeonatal periodMental scoresGerminal matrixTherapyIVHUnderlying disturbanceInfantsAdverse effectsFurther studiesNeonatesCognitive functioningHarmful effectsMetabolismApneaNeurodevelopmental assessment of very low birth weight neonates: Effect of germinal matrix and intraventricular hemorrhage
Ment L, Scott D, Ehrenkranz R, Duncan C. Neurodevelopmental assessment of very low birth weight neonates: Effect of germinal matrix and intraventricular hemorrhage. Pediatric Neurology 1985, 1: 164-168. PMID: 3880401, DOI: 10.1016/0887-8994(85)90058-x.Peer-Reviewed Original ResearchConceptsGMH/IVHIntraventricular hemorrhageNeurodevelopmental assessmentGerminal matrixSurviving infantsNeonatal germinal matrix hemorrhageNewborn Special Care UnitLow birth weight neonatesBirth weight neonatesGerminal matrix hemorrhageMajor neurologic abnormalitiesSpecial care unitsNon-hemorrhage groupWeight neonatesCare unitGroup infantsPostnatal hoursNeurologic abnormalitiesBirth weightSevere gradesHemorrhageDevelopmental scoresBayley ScalesInfantsInfant developmentPerinatal Cerebral Insults: Hemorrhage and Ischemia
Ment L, Duncan C, Stewart W. Perinatal Cerebral Insults: Hemorrhage and Ischemia. Pediatric Neurosurgery 1985, 12: 168-174. PMID: 3916368, DOI: 10.1159/000120242.Peer-Reviewed Original ResearchConceptsMajor neurodevelopmental handicapsCerebral blood flowNeurodevelopmental handicapParenchymal involvementCerebral infarctionPreterm infantsIntraventricular hemorrhageGestational ageIschemic insultPerinatal careHigh riskBlood flowHemorrhageInfantsDevelopmental abnormalitiesCareInfarctionIschemiaNeonatesLesionsAbnormalitiesIncidenceInsultSurvivorsBrain
1984
Perinatal cerebral infarction
Ment L, Duncan C, Ehrenkranz R. Perinatal cerebral infarction. Annals Of Neurology 1984, 16: 559-568. PMID: 6508239, DOI: 10.1002/ana.410160506.Peer-Reviewed Original ResearchMeSH KeywordsAsphyxia NeonatorumCerebral HemorrhageCerebral InfarctionCerebral VentriclesHumansInfant, NewbornInfant, Premature, DiseasesIntracranial Embolism and ThrombosisTomography, X-Ray ComputedConceptsPerinatal cerebral infarctionCerebral infarctionNeonatal intraventricular hemorrhageFull-term infantsMonths of ageTwelve-month intervalsPerinatal asphyxiaPreterm neonatesIntraventricular hemorrhageNeonatal seizuresTomographic scanCommon causePostmortem examinationInfarctionInfantsStrokeAsphyxiaHemorrhageNeonatesSeizuresUteroDiagnosisMonthsDelayed Hemorrhagic Infarction: A Cause of Late Neonatal Germinal Matrix and Intraventricular Hemorrhage
Ment L, Ehrenkranz R, Duncan C, Lange R. Delayed Hemorrhagic Infarction: A Cause of Late Neonatal Germinal Matrix and Intraventricular Hemorrhage. JAMA Neurology 1984, 41: 1036-1039. PMID: 6477210, DOI: 10.1001/archneur.1984.04050210034010.Peer-Reviewed Original ResearchMeSH KeywordsCerebral HemorrhageCerebral InfarctionCerebral VentriclesCerebrovascular CirculationFemaleHumansInfant, NewbornInfant, Premature, DiseasesMaleConceptsCerebral blood flowLow cerebral blood flowLate intraventricular hemorrhageIntraventricular hemorrhageFirst postnatal dayMonths of ageSeries of insultsProfound hypotensionPorencephalic cystPostnatal eventsGerminal matrixPostnatal dayBlood flowHemorrhageNeonatesTomographic evidenceInfarcted tissueHypotensionTissueAsphyxiaEncephalomalaciaInfarctionInfantsCystsInsult
1983
Postpartum Perfusion of the Preterm Brain: Relationship to Neurodevelopmental Outcome
Ment L, Scott D, Lange R, Ehrenkranz R, Duncan C, Warshaw J. Postpartum Perfusion of the Preterm Brain: Relationship to Neurodevelopmental Outcome. Child's Brain 1983, 10: 266-272. PMID: 6884128, DOI: 10.1159/000120122.Peer-Reviewed Original ResearchConceptsCerebral blood flow measurementsCBF valuesHigher CBF valuesComputerized tomography scanDays of lifeBlood flow measurementsIntraventricular hemorrhageNeurodevelopmental outcomesPreterm brainPreterm infantsFavorable outcomeTomography scanMental indexDevelopmental assessmentLeft hemisphereOutcomesHemorrhageInfantsPerfusion
1982
Neonates of less than or equal to 1,250 grams birth weight: prospective neurodevelopmental evaluation during the first year post-term.
Ment L, Scott D, Ehrenkranz R, Rothman S, Duncan C, Warshaw J. Neonates of less than or equal to 1,250 grams birth weight: prospective neurodevelopmental evaluation during the first year post-term. Pediatrics 1982, 70: 292-6. PMID: 7099799, DOI: 10.1542/peds.70.2.292.Peer-Reviewed Original ResearchConceptsNeonatal intensive careIntraventricular hemorrhagePreterm neonatesIntensive careBirth weightIncidence of IVHNewborn Special Care UnitSophisticated neonatal intensive careGm birth weightGrams birth weightIll preterm neonatesSpecial care unitsConsecutive preterm neonatesYears of lifeNeurodevelopmental handicapCare unitPostnatal hoursProspective studyNeurodevelopmental evaluationMotor handicapEarly identificationGreater riskNeonatesDelayed acquisitionDevelopmental problems
1981
Alterations in cerebral blood flow in preterm infants with intraventricular hemorrhage.
Ment L, Ehrenkranz R, Lange R, Rothstein P, Duncan C. Alterations in cerebral blood flow in preterm infants with intraventricular hemorrhage. Pediatrics 1981, 68: 763-9. PMID: 7322711, DOI: 10.1542/peds.68.6.763.Peer-Reviewed Original ResearchMeSH KeywordsCerebral HemorrhageCerebral VentriclesCerebrovascular CirculationHumansInfantInfant, NewbornInfant, Premature, DiseasesTomography, X-Ray ComputedXenon RadioisotopesConceptsWeeks postconceptual ageGerminal matrix hemorrhageIntraventricular hemorrhageIVH groupPreterm infantsPostconceptual ageCerebral blood flow determinationsCerebral blood flowComputed tomography scanGroups of infantsBlood flow determinationsNonhemorrhage patientsIVH patientsAutopsy findingsTomography scanCT scanBlood flowHemorrhageHemispheric ratioInfantsMean differencePatientsLower mean valuesInterhemispheric ratioAgeA Scale for the Assessment of Neonatal Neurologic Status
Duncan C, Ment L, Smith B, Ehrenkranz R. A Scale for the Assessment of Neonatal Neurologic Status. Child's Brain 1981, 8: 299-306. PMID: 7261694, DOI: 10.1159/000119993.Peer-Reviewed Original ResearchMeSH KeywordsArousalBrain DiseasesCritical CareHumansInfant, NewbornInfant, Newborn, DiseasesInfant, Premature, DiseasesMotor ActivityNeurologic Examination