Perforin and Fas Ligand Are Required for the Regulation of Alloreactive CD8+ T Cells.
Maeda Y, Levy R, Reddy P, Liu C, Teshima T, Ferrara J. Perforin and Fas Ligand Are Required for the Regulation of Alloreactive CD8+ T Cells. Blood 2004, 104: 3052. DOI: 10.1182/blood.v104.11.3052.3052.Peer-Reviewed Original ResearchDonor T cellsT cellsDonor CD8WT T cellsAlloreactive CD8Day 10Day 30Host antigen presenting cellsFas ligandSingle MHC class IHost dendritic cellsModel of graftT cell populationsAntigen presenting cellsT cell homeostasisFas ligand pathwayMHC class IAllogeneic CD8Bm1 miceLethal GVHDSevere GVHDSignificant GVHDHost diseaseBMT recipientsEpithelial target cellsBoth perforin and Fas ligand are required for the regulation of alloreactive CD8+ T cells during acute graft-versus-host disease
Maeda Y, Levy R, Reddy P, Liu C, Clouthier S, Teshima T, Ferrara J. Both perforin and Fas ligand are required for the regulation of alloreactive CD8+ T cells during acute graft-versus-host disease. Blood 2004, 105: 2023-2027. PMID: 15466930, DOI: 10.1182/blood-2004-08-3036.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAnimalsBone Marrow TransplantationCD8-Positive T-LymphocytesCell Culture TechniquesFas Ligand ProteinGraft vs Host DiseaseHistocompatibilityHistocompatibility Antigens Class ILymphocyte TransfusionMembrane GlycoproteinsMiceMice, Inbred StrainsModels, AnimalPerforinPore Forming Cytotoxic ProteinsTransplantation, HomologousConceptsT cellsHost diseaseAllogeneic bone marrow transplantationT cell-mediated cytotoxicityTumor necrosis factor alphaMajor histocompatibility complex class IGreater serum levelsDonor T cellsBone marrow transplantationCell-mediated cytotoxicityHistocompatibility complex class IWild-type T cellsNecrosis factor alphaComplex class ILethal GVHDAcute graftAlloreactive CD8Histopathologic damageMarrow transplantationSerum levelsAlloantigen stimulationIrradiated murine modelFactor alphaCD8Murine model