2020
S139. PROGRESSIVE DETERIORATION OF WHITE MATTER TRACTS IN SCHIZOPHRENIA: A DIFFUSION MRI STUDY ON A LARGE SINGLE COHORT USING NORMATIVE MODELS
Hwang T, Tung Y, Chen C, Yang L, Hsu Y, Hwu H, Liu C, Chien Y, Hsieh M, Lin Y, Liu C, Tseng W. S139. PROGRESSIVE DETERIORATION OF WHITE MATTER TRACTS IN SCHIZOPHRENIA: A DIFFUSION MRI STUDY ON A LARGE SINGLE COHORT USING NORMATIVE MODELS. Schizophrenia Bulletin 2020, 46: s88-s89. PMCID: PMC7234280, DOI: 10.1093/schbul/sbaa031.205.Peer-Reviewed Original ResearchFirst-episode schizophreniaGeneralized fractional anisotropyChronic schizophreniaPrefrontal lobeEarly stages of schizophreniaMean diffusivityRadial diffusivityStages of schizophreniaAbnormalities of white matterStudies of schizophreniaAxial diffusivityNeural tractsDuration of illnessWhite matter tractsSchizophreniaSingle-site cohortDiffusion MRI studiesFractional anisotropySensorimotor cortexNormative modelDiffusion-weighted imagingHealthy peopleWhite matter involvementMRI studiesNormal controls
2018
T182. SHARED AND DISTINCT ALTERATIONS IN THE WHITE MATTER TRACTS OF REMITTED AND NON-REMITTED PATIENTS WITH SCHIZOPHRENIA
Hwang T, Huang J, Liu C, Chen Y, Hsu Y, Hwu H, Lin Y, Hsieh M, Liu C, Chien Y, Tseng W. T182. SHARED AND DISTINCT ALTERATIONS IN THE WHITE MATTER TRACTS OF REMITTED AND NON-REMITTED PATIENTS WITH SCHIZOPHRENIA. Schizophrenia Bulletin 2018, 44: s186-s187. PMCID: PMC5888289, DOI: 10.1093/schbul/sby016.458.Peer-Reviewed Original ResearchGeneralized fractional anisotropy valuesGeneralized fractional anisotropyBilateral temporal polesWhite matter tract integrityGray matter volumeUncinate fasciculusLimbic systemTemporal poleNon-remission groupBilateral amygdalaBilateral fornixBilateral hippocampiMatter volumeTract integrityReduced gray matter volumeTreatment outcomesCallosal fibersSchizophrenia Working GroupGray matter reductionsBilateral uncinate fasciculusGray matter alterationsTract-based spatial statisticsSuperior longitudinal fasciculusTesla magnetic resonance imaging scannerWhite matter tract alterationsShared and distinct alterations of white matter tracts in remitted and nonremitted patients with schizophrenia
Huang J, Liu C, Hwang T, Chen Y, Hsu Y, Hwu H, Lin Y, Hsieh M, Liu C, Chien Y, Tseng W. Shared and distinct alterations of white matter tracts in remitted and nonremitted patients with schizophrenia. Human Brain Mapping 2018, 39: 2007-2019. PMID: 29377322, PMCID: PMC6866389, DOI: 10.1002/hbm.23982.Peer-Reviewed Original ResearchConceptsGeneralized fractional anisotropyGeneralized fractional anisotropy valuesAdequate antipsychotic treatmentNegative symptom scoresNonremission groupWhite matter tract integrityWhite matter integrityHealthy controlsRemission stateWhite matter tract bundlesWhite matter tractsReduced integrationAntipsychotic treatmentNonremitted patientsSchizophrenia patientsSymptomatic remissionIllness durationAnalysis of covarianceSchizophreniaDiffusion spectrum imagingTract integrityPost hoc analysisFractional anisotropyMedication dosesEducation years