2011
Host-Derived IL-22 Limits Graft Versus Host Disease and Protects the Intestinal Stem Cell Niche
Hanash A, Dudakov J, Hua G, Young L, O'connor M, Jenq R, Holland A, Smith O, Liu C, Fouser L, Kolesnick R, Blazar B, Van Den Brink M. Host-Derived IL-22 Limits Graft Versus Host Disease and Protects the Intestinal Stem Cell Niche. Blood 2011, 118: 309. DOI: 10.1182/blood.v118.21.309.309.Peer-Reviewed Original ResearchInnate lymphoid cellsIL-22 deficiencyDonor immune responsesIL-22R expressionIL-22Post-BMTIntestinal stem cellsIntestinal epitheliumGVHD mortalityKO recipientsHost diseaseClinical GVHDT cellsImmune responseIL-22-producing innate lymphoid cellsGraft Versus Host DiseaseIL-22 KO miceLarge intestineMurine bone marrow transplantationHost hematopoietic cellsTarget of GVHDVersus Host DiseaseIL-22 productionDonor immune systemIL-22 levels
2004
CCR1 Expression on Donor Leukocytes Is Critical to the Development of Graft Versus Host Disease after Allogeneic SCT.
Hildebrandt G, Choi S, Olkiewicz K, Chensue S, Liu C, Cooke K. CCR1 Expression on Donor Leukocytes Is Critical to the Development of Graft Versus Host Disease after Allogeneic SCT. Blood 2004, 104: 3067. DOI: 10.1182/blood.v104.11.3067.3067.Peer-Reviewed Original ResearchT cell responsesAllo-SCTCCR1 expressionDonor leukocytesHost diseaseT cellsCell responsesDonor T-cell responsesGraft Versus Host DiseaseAllogeneic stem cell transplantationSerum IFNγ levelsTranslocation of endotoxinVersus Host DiseaseDonor T cellsSeverity of GVHDDonor cellsClinical scoring systemStem cell transplantationT cell expansionAcute graftGVL effectSignificant GVHDTNFa levelsAllogeneic SCTClinical GVHDIL-13 - Predictor of or Protector from Acute Graft Versus Host Disease?.
Hildebrandt G, Olkiewicz K, Choi S, Corrion L, Liu C, McKenzie A, Cooke K. IL-13 - Predictor of or Protector from Acute Graft Versus Host Disease?. Blood 2004, 104: 3070. DOI: 10.1182/blood.v104.11.3070.3070.Peer-Reviewed Original ResearchBALB/c ILStem cell transplantationDonor T cellsIL-13T cellsC ILSyngeneic controlsTNFa levelsAllo-SCTHost diseaseTh2 cytokinesDonor cellsAcute Graft Versus Host DiseaseGraft Versus Host DiseaseAllogeneic stem cell transplantationTh1-type cytokine responseAltered cytokine milieuDay 100 survivalRecipients of ILTypical Th2 cytokineSeverity of GVHDVersus Host DiseaseIL-13 levelsIL-5 levelsPathogenesis of GVHD