2010
Clonal Expansion of Normal-Appearing Human Hepatocytes during Chronic Hepatitis B Virus Infection
Mason W, Liu C, Aldrich C, Litwin S, Yeh M. Clonal Expansion of Normal-Appearing Human Hepatocytes during Chronic Hepatitis B Virus Infection. Journal Of Virology 2010, 84: 8308-8315. PMID: 20519397, PMCID: PMC2916518, DOI: 10.1128/jvi.00833-10.Peer-Reviewed Original ResearchConceptsChronic hepatitis B virus infectionHepatitis B virus infectionB virus infectionExtensive clonal expansionClonal expansionHBV DNAInfected hepatocytesNoncirrhotic liverVirus infectionHepatocellular carcinomaImmune killingHuman HBV carriersNormal-appearing hepatocytesHuman hepatocytesWoodchuck hepatitis virusIntegrated HBV DNAHBV carriersSurgical resectionChronic infectionHepatitis virusNoncancerous liverInfectionLiverTissue sectionsHepatocytes
2009
Primary Human Hepatocyte Culture for HCV Study
Zhu H, Elyar J, Foss R, Hemming A, Hall E, LeCluyse E, Liu C. Primary Human Hepatocyte Culture for HCV Study. Methods In Molecular Biology 2009, 510: 373-382. PMID: 19009276, DOI: 10.1007/978-1-59745-394-3_28.Peer-Reviewed Original ResearchConceptsHuman primary hepatocytesAntiviral researchPrimary hepatocyte culturesHuman primary hepatocyte culturesSmall animal modelsPrimary hepatocytesHepatocyte culturesPrimary human hepatocyte culturesHCV infectionHCV pathogenesisLiver perfusionHuman hepatocyte culturesHCV researchHost-virus interactionsInfectious virusHCV studiesPrimary culturesCell model systemHepatocyte isolationHepatocytesJFH1PathogenesisPerfusionInfection
2008
Repopulation of human hepatocytes in immunodeficient mice
Liu C, Witek R, Bess J, Zhu H, Lin P. Repopulation of human hepatocytes in immunodeficient mice. The FASEB Journal 2008, 22: 465.4-465.4. DOI: 10.1096/fasebj.22.1_supplement.465.4.Peer-Reviewed Original ResearchHuman hepatitis C virusHuman hepatocytesHepatitis C virusTime of hepatectomyHumanized mouse modelHuman liver diseaseRepopulation efficiencyLiver diseaseC virusHepatocyte repopulationImmunodeficient miceMouse modelTransgenic miceLiver tissueHepatocyte proliferationPartial hepatectomyMiceSerum samplesMonocrotalineMouse liverHepatectomyHepatocytesDiseaseLiverProtein markers
2000
Apoptosis and Regeneration of Hepatocytes during Recovery from Transient Hepadnavirus Infections
Guo J, Zhou H, Liu C, Aldrich C, Saputelli J, Whitaker T, Barrasa M, Mason W, Seeger C. Apoptosis and Regeneration of Hepatocytes during Recovery from Transient Hepadnavirus Infections. Journal Of Virology 2000, 74: 1495-1505. PMID: 10627561, PMCID: PMC111485, DOI: 10.1128/jvi.74.3.1495-1505.2000.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesDNA, ViralHepatitis BHepatitis B Virus, WoodchuckHepatitis B, ChronicInterferon-gammaLiverLiver RegenerationMarmotaMolecular Sequence DataReverse Transcriptase Polymerase Chain ReactionTumor Necrosis Factor-alphaViremiaConceptsRegeneration of hepatocytesHepadnavirus infectionTransient infectionHepatitis B virus infectionTumor necrosis factor alphaTransient hepadnavirus infectionsB virus infectionT cell accumulationNecrosis factor alphaCytokine expressionInfected hepatocytesFactor alphaT cellsVirus infectionInterferon gammaInfected liverHistologic analysisLiver tissueInfectionRecovery periodSignificant increaseHepatocytesInitial influxUnknown mechanismApoptosis