2022
Niacin skin flush and membrane polyunsaturated fatty acids in schizophrenia from the acute state to partial remission: a dynamic relationship
Yu Y, Su H, Lin S, Hsiao P, Lin Y, Liu C, Hwang T, Hsieh M, Liu C, Chien Y, Kuo C, Hwu H, Chen W. Niacin skin flush and membrane polyunsaturated fatty acids in schizophrenia from the acute state to partial remission: a dynamic relationship. Schizophrenia 2022, 8: 38. PMID: 35853900, PMCID: PMC9261101, DOI: 10.1038/s41537-022-00252-w.Peer-Reviewed Original ResearchSchizophrenia patientsMembrane polyunsaturated fatty acidsNiacin skin testFlushing responseArachidonic acid levelsArachidonic acidFollow-upIncreased turnover of arachidonic acidSkin testFlush scorePolyunsaturated fatty acidsVulnerability to schizophreniaTurnover of arachidonic acidDihomo-gamma-linolenic acidSchizophrenia inpatientsPartial remissionSchizophreniaAcute exacerbationSkin flushingHealthy controlsControl-to-case ratioPatientsPersistent decreaseDocosahexaenoic acidIncreased turnover
2016
Aberrant expression of microRNAs as biomarker for schizophrenia: from acute state to partial remission, and from peripheral blood to cortical tissue
Lai C, Lee S, Scarr E, Yu Y, Lin Y, Liu C, Hwang T, Hsieh M, Liu C, Chien Y, Udawela M, Gibbons A, Everall I, Hwu H, Dean B, Chen W. Aberrant expression of microRNAs as biomarker for schizophrenia: from acute state to partial remission, and from peripheral blood to cortical tissue. Translational Psychiatry 2016, 6: e717-e717. PMID: 26784971, PMCID: PMC5068884, DOI: 10.1038/tp.2015.213.Peer-Reviewed Original ResearchConceptsPeripheral miRNAsState-dependent markersDiagnostic of schizophreniaHsa-miR-34aPostmortem brain tissueAberrant expression of microRNAsCaudate putamenSchizophreniaSubcortical regionsAcute stateExpression of microRNAsSeven-miRNARemission stateBrain samplesAberrant expressionClinically useful biomarkersExpression levelsBrainMonths of hospitalizationPartial remission stateAge-dependent increaseMiRNA dysregulationMiRNAsPartial remissionClinical symptoms