2008
Combined Th2 cytokine deficiency in donor T cells aggravates experimental acute graft-vs-host disease
Tawara I, Maeda Y, Sun Y, Lowler K, Liu C, Toubai T, McKenzie A, Reddy P. Combined Th2 cytokine deficiency in donor T cells aggravates experimental acute graft-vs-host disease. Experimental Hematology 2008, 36: 988-996. PMID: 18410989, PMCID: PMC2603625, DOI: 10.1016/j.exphem.2008.02.010.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAnimalsBone Marrow TransplantationCD4-Positive T-LymphocytesCell ProliferationDisease Models, AnimalEnzyme-Linked Immunosorbent AssayFemaleFlow CytometryGraft vs Host DiseaseImmunologic TestsInterleukin-2 Receptor alpha SubunitInterleukinsMajor Histocompatibility ComplexMiceMice, Inbred BALB CMice, Inbred C57BLSurvival RateT-LymphocytesTh2 CellsTransplantation, HomologousConceptsDonor T cellsT cellsWT T cellsTh2 cytokinesAcute graftAllogeneic bone marrow transplantationAllogeneic antigen-presenting cellsT cell proliferative responsesAnti-CD3 monoclonal antibodyEnhanced T cell proliferationExperimental acute graftNumber of immunoregulatoryTarget organ damageTh2 cytokine secretionBone marrow transplantationT helper 1Antigen-presenting cellsWild-type T cellsT cell proliferationGreater clinical severityBALB/cB6 recipientsGVHD mortalityHost diseaseIL-17
2004
IL-13 - Predictor of or Protector from Acute Graft Versus Host Disease?.
Hildebrandt G, Olkiewicz K, Choi S, Corrion L, Liu C, McKenzie A, Cooke K. IL-13 - Predictor of or Protector from Acute Graft Versus Host Disease?. Blood 2004, 104: 3070. DOI: 10.1182/blood.v104.11.3070.3070.Peer-Reviewed Original ResearchBALB/c ILStem cell transplantationDonor T cellsIL-13T cellsC ILSyngeneic controlsTNFa levelsAllo-SCTHost diseaseTh2 cytokinesDonor cellsAcute Graft Versus Host DiseaseGraft Versus Host DiseaseAllogeneic stem cell transplantationTh1-type cytokine responseAltered cytokine milieuDay 100 survivalRecipients of ILTypical Th2 cytokineSeverity of GVHDVersus Host DiseaseIL-13 levelsIL-5 levelsPathogenesis of GVHD