2011
Host Basophils Are Dispensable for Induction of Donor T Helper 2 Cell Differentiation and Severity of Experimental Graft-versus-Host Disease
Tawara I, Nieves E, Liu C, Evers R, Toubai T, Sun Y, Alrubaie M, Reddy P. Host Basophils Are Dispensable for Induction of Donor T Helper 2 Cell Differentiation and Severity of Experimental Graft-versus-Host Disease. Transplantation And Cellular Therapy 2011, 17: 1747-1753. PMID: 21871863, PMCID: PMC3220796, DOI: 10.1016/j.bbmt.2011.08.013.Peer-Reviewed Original ResearchConceptsAntigen-presenting cellsAllogeneic bone marrow transplantationSeverity of GVHDBone marrow transplantationHost diseaseTh2 responsesMarrow transplantationDonor T cell proliferationDonor T-cell responsesInduction of graftT cell responsesT cell proliferationT helper 2 (Th2) cell differentiationTh2 polarizationLymphocyte responsesExperimental graftGVHDCell responsesBasophilsCell proliferationSeverityTransplantationGraftRecent dataDisease
2001
Interleukin-18 Regulates Acute Graft-Versus-Host Disease by Enhancing Fas-mediated Donor T Cell Apoptosis
Reddy P, Teshima T, Kukuruga M, Ordemann R, Liu C, Lowler K, Ferrara J. Interleukin-18 Regulates Acute Graft-Versus-Host Disease by Enhancing Fas-mediated Donor T Cell Apoptosis. Journal Of Experimental Medicine 2001, 194: 1433-1440. PMID: 11714750, PMCID: PMC2193680, DOI: 10.1084/jem.194.10.1433.Peer-Reviewed Original ResearchConceptsDonor T cellsIL-18Acute GVHDHost diseaseT cellsDonor T cell expansionSerum tumor necrosis factorT helper type 1Acute Graft-VersusGamma knockout miceGVHD-related mortalityMurine bone marrow transplantation modelBone marrow transplantation modelHelper type 1T cell expansionTumor necrosis factorFas-deficient miceT cell apoptosisAcute graftGraft-VersusBMT recipientsIntestinal histopathologyTh2 responsesInterleukin-18Transplantation model