2009
Cytolytic T cells induce ceramide-rich platforms in target cell membranes to initiate graft-versus-host disease
Rotolo J, Stancevic B, Lu S, Zhang J, Suh D, King C, Kappel L, Murphy G, Liu C, Fuks Z, van den Brink M, Kolesnick R. Cytolytic T cells induce ceramide-rich platforms in target cell membranes to initiate graft-versus-host disease. Blood 2009, 114: 3693-3706. PMID: 19666872, PMCID: PMC2766684, DOI: 10.1182/blood-2008-11-191148.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisBone Marrow TransplantationCD8-Positive T-LymphocytesCell MembraneCeramidesCytokinesDisease Models, AnimalFemaleGraft vs Host DiseaseHepatocytesInterferon-gammaIntestine, SmallLiverLymphocyte ActivationMaleMiceMice, Inbred C57BLMice, Inbred MRL lprMice, SCIDSkinSphingomyelin PhosphodiesteraseSurvival RateT-Lymphocytes, CytotoxicConceptsHost diseaseT cellsT cell proliferation/activationAllogeneic bone marrowAcute inflammatory phaseRelevant mouse modelTumor necrosis factorCytolytic T cellsProliferation/activationCytolytic T lymphocytesPotential new targetsHost target cellsTarget cell membraneAcute graftAcute GVHDGVHD progressionCytokine stormOrgan injuryNecrosis factorGVHDInflammatory phaseRelevant graftT lymphocytesMouse modelBone marrow
2004
A Role for Tumor Necrosis Factor-&agr;-Mediated Endothelial Apoptosis in the Development of Experimental Idiopathic Pneumonia Syndrome
Gerbitz A, Nickoloff B, Olkiewicz K, Willmarth N, Hildebrandt G, Liu C, Kobzik L, Eissner G, Holler E, Ferrara J, Cooke K. A Role for Tumor Necrosis Factor-&agr;-Mediated Endothelial Apoptosis in the Development of Experimental Idiopathic Pneumonia Syndrome. Transplantation 2004, 78: 494-502. PMID: 15446306, DOI: 10.1097/01.tp.0000128839.13674.02.Peer-Reviewed Original ResearchConceptsExperimental Idiopathic Pneumonia SyndromeAllogeneic bone marrow transplantationIdiopathic pneumonia syndromeBone marrow transplantationTumor necrosis factorLung injuryTNF-alphaPneumonia syndromeNecrosis factorVascular endotheliumBronchoalveolar lavage fluid tumor necrosis factorDevelopment of IPSPulmonary vascular endothelial cell apoptosisAlloreactive donor T cellsInflammatory mediators TNF-alphaMinor histocompatibility antigenic differencesMurine BMT systemPulmonary vascular endotheliumDonor T cellsEC apoptosisVascular endothelial cell apoptosisEndothelial cell apoptosisHost diseaseLung histopathologyPulmonary histopathology
2002
Acute graft-versus-host disease does not require alloantigen expression on host epithelium
Teshima T, Ordemann R, Reddy P, Gagin S, Liu C, Cooke K, Ferrara J. Acute graft-versus-host disease does not require alloantigen expression on host epithelium. Nature Medicine 2002, 8: 575-581. PMID: 12042807, DOI: 10.1038/nm0602-575.Peer-Reviewed Original ResearchConceptsAntigen-presenting cellsHost antigen-presenting cellsAlloantigen expressionAcute GVHDHost diseaseTarget epitheliaMajor histocompatibility complex class ICD8-mediated GVHDBone marrow chimerasHistocompatibility complex class IClass II alloantigensTumor necrosis factorComplex class IAcute graftInflammatory cytokinesEffector mechanismsGVHDNecrosis factorMouse modelAntigen specificityTissue damageClass IHost epitheliumEpitheliumGraft
2001
Interleukin-18 Regulates Acute Graft-Versus-Host Disease by Enhancing Fas-mediated Donor T Cell Apoptosis
Reddy P, Teshima T, Kukuruga M, Ordemann R, Liu C, Lowler K, Ferrara J. Interleukin-18 Regulates Acute Graft-Versus-Host Disease by Enhancing Fas-mediated Donor T Cell Apoptosis. Journal Of Experimental Medicine 2001, 194: 1433-1440. PMID: 11714750, PMCID: PMC2193680, DOI: 10.1084/jem.194.10.1433.Peer-Reviewed Original ResearchConceptsDonor T cellsIL-18Acute GVHDHost diseaseT cellsDonor T cell expansionSerum tumor necrosis factorT helper type 1Acute Graft-VersusGamma knockout miceGVHD-related mortalityMurine bone marrow transplantation modelBone marrow transplantation modelHelper type 1T cell expansionTumor necrosis factorFas-deficient miceT cell apoptosisAcute graftGraft-VersusBMT recipientsIntestinal histopathologyTh2 responsesInterleukin-18Transplantation model