2011
Expression of an IRF-3 fusion protein and mouse estrogen receptor, inhibits hepatitis C viral replication in RIG-I-deficient Huh 7.5 cells
Yao L, Yan X, Dong H, Nelson D, Liu C, Li X. Expression of an IRF-3 fusion protein and mouse estrogen receptor, inhibits hepatitis C viral replication in RIG-I-deficient Huh 7.5 cells. Virology Journal 2011, 8: 445. PMID: 21936899, PMCID: PMC3213043, DOI: 10.1186/1743-422x-8-445.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell LineDEAD Box Protein 58DEAD-box RNA HelicasesGene ExpressionHepacivirusHepatocytesHumansInterferon Regulatory Factor-3Interferon-alphaInterferon-betaMiceProtein BiosynthesisProtein MultimerizationReal-Time Polymerase Chain ReactionReceptors, EstrogenReceptors, ImmunologicRecombinant Fusion ProteinsTranscription, GeneticVirus ReplicationConceptsAnti-HCV effectInterferon regulatory factor 3Huh-7.5 cellsEstrogen receptorPolymerase chain reactionHepatitis C virus infectionViral replicationC virus infectionMouse estrogen receptorHepatitis C viral replicationInterferon-stimulated gene expressionExpression of IFNHCV viral replicationHCV RNA replicationReal-time polymerase chain reactionEstrogen receptor agonistsExpression of ISGsRegulatory factor 3HCV IRES-dependent translationCharacterization of HCV Interactions with Toll-Like Receptors and RIG-I in Liver Cells
Eksioglu E, Zhu H, Bayouth L, Bess J, Liu H, Nelson D, Liu C. Characterization of HCV Interactions with Toll-Like Receptors and RIG-I in Liver Cells. PLOS ONE 2011, 6: e21186. PMID: 21695051, PMCID: PMC3117876, DOI: 10.1371/journal.pone.0021186.Peer-Reviewed Original ResearchMeSH KeywordsCell DeathCell Line, TumorDEAD Box Protein 58DEAD-box RNA HelicasesDown-RegulationHepacivirusHost-Pathogen InteractionsHumansInterferon-betaLiverProtein BindingReceptors, ImmunologicSignal TransductionTNF-Related Apoptosis-Inducing LigandToll-Like ReceptorsViral Envelope ProteinsVirus ReplicationConceptsHuh7.5 cellsViral replicationHCV chronic patientsExpression of TLR3Toll-like receptorsHCV envelope proteinsExpression levelsRIG-I expressionHCV interactionChronic patientsHCVTRAIL pathwayViral escapeViral infectionInnate immunityViral pathogenesisTLR3Induction of apoptosisAntiviral stateIFN inductionLow expression levelsLiver cellsLH86Envelope proteinIFN
2007
Hepatitis C Virus Triggers Apoptosis of a Newly Developed Hepatoma Cell Line Through Antiviral Defense System
Zhu H, Dong H, Eksioglu E, Hemming A, Cao M, Crawford J, Nelson D, Liu C. Hepatitis C Virus Triggers Apoptosis of a Newly Developed Hepatoma Cell Line Through Antiviral Defense System. Gastroenterology 2007, 133: 1649-1659. PMID: 17983809, DOI: 10.1053/j.gastro.2007.09.017.Peer-Reviewed Original ResearchConceptsTumor necrosis factor-related apoptosis-inducing ligandHCV infectionViral infectionHepatoma cell lineHCV isolatesJFH-1New hepatoma cell lineViral replicationCell linesMechanisms of HCVAcute HCV infectionChronic viral infectionsPathogenesis of HCVNovel human hepatoma cell lineInterferon response factor 3Antiviral defense systemNecrosis factor-related apoptosis-inducing ligandType I interferon inductionFactor-related apoptosis-inducing ligandExpression of interferonHost immune systemHepatocellular carcinoma tissuesI interferon inductionDeath receptor 5Induction of interferon
2005
Cyclosporine suppresses hepatitis C virus in vitro and increases the chance of a sustained virological response after liver transplantation
Firpi R, Zhu H, Morelli G, Abdelmalek M, Soldevila‐Pico C, Machicao V, Cabrera R, Reed A, Liu C, Nelson D. Cyclosporine suppresses hepatitis C virus in vitro and increases the chance of a sustained virological response after liver transplantation. Liver Transplantation 2005, 12: 51-57. PMID: 16382464, DOI: 10.1002/lt.20532.Peer-Reviewed Original ResearchConceptsLiver transplant recipientsSustained virological responseVirological responseTransplant recipientsCombination of cyclosporineInterferon-based therapyCombination of interferonEffect of cyclosporineDose-dependent mannerAnti-viral potentialLiver transplantationHistologic diseaseImmunosuppressive agentsViral clearanceHerpes simplexC virusAntiviral effectCyclosporine inhibitsCyclosporineTherapyViral replicationAntiviral activityTacrolimusInterferonReplicon system