2021
The Diversity of Vaginal Microbiota Predicts Neoadjuvant Chemotherapy Responsiveness in Locally Advanced Cervical Cancer
Wang Z, Xiao R, Huang J, Qin X, Hu D, Guo E, Liu C, Lu F, You L, Sun C, Chen G. The Diversity of Vaginal Microbiota Predicts Neoadjuvant Chemotherapy Responsiveness in Locally Advanced Cervical Cancer. Microbial Ecology 2021, 84: 302-313. PMID: 34405250, DOI: 10.1007/s00248-021-01800-0.Peer-Reviewed Original ResearchMeSH KeywordsFemaleHumansMicrobiotaNeoadjuvant TherapyRNA, Ribosomal, 16SUterine Cervical NeoplasmsVaginaConceptsLocally advanced cervical cancerLocally advanced cervical cancer patientsPlatinum-based chemotherapy responseAdvanced cervical cancerCervical cancerChemotherapy responseAlpha diversityVaginal microbiotaVaginal samplesCC patientsVaginal microbiomeHealthy controlsPredicting neoadjuvant chemotherapy responsePlatinum-resistant patientsNeoadjuvant chemotherapy responseAssociated with platinum-based chemotherapy responseCervical cancer patientsVaginal microbiota diversityNeoadjuvant chemotherapyHPV infectionBeta diversityBacteroides genusChemotherapy effectCancer patientsBacteroides abundanceFecal microbiota transplantation mitigates vaginal atrophy in ovariectomized mice
Huang J, Shan W, Li F, Wang Z, Cheng J, Lu F, Guo E, Beejadhursing R, Xiao R, Liu C, Yang B, Li X, Fu Y, Xi L, Wang S, Ma D, Chen G, Sun C. Fecal microbiota transplantation mitigates vaginal atrophy in ovariectomized mice. Aging 2021, 13: 7589-7607. PMID: 33658399, PMCID: PMC7993734, DOI: 10.18632/aging.202627.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAtrophyFecal Microbiota TransplantationFemaleGastrointestinal MicrobiomeMiceMice, Inbred C57BLOvariectomyRNA, Ribosomal, 16SVaginaConceptsVulvovaginal atrophyFecal microbiota transplantationOvarian functionFemale miceMicrobiota transplantationGut microbiotaVagina of miceMenopause-related symptomsVaginal atrophyEpithelial atrophyHormone therapyEstrogen deficiencyVaginal cellsOvariectomized miceOvariectomized onesVaginal healthFollow-upOld miceCancer patientsAlternative treatmentVaginaMiceModulating gut microbiotaOlder womenAtrophy
2012
Regulation of intestinal inflammation by microbiota following allogeneic bone marrow transplantation
Jenq R, Ubeda C, Taur Y, Menezes C, Khanin R, Dudakov J, Liu C, West M, Singer N, Equinda M, Gobourne A, Lipuma L, Young L, Smith O, Ghosh A, Hanash A, Goldberg J, Aoyama K, Blazar B, Pamer E, van den Brink M. Regulation of intestinal inflammation by microbiota following allogeneic bone marrow transplantation. Journal Of Experimental Medicine 2012, 209: 903-911. PMID: 22547653, PMCID: PMC3348096, DOI: 10.1084/jem.20112408.Peer-Reviewed Original ResearchConceptsAllogeneic bone marrow transplantationBone marrow transplantationIntestinal inflammationMarrow transplantationAllogeneic BMT recipientsPotential risk factorsSubsequent GVHDHost diseaseBMT recipientsRisk factorsGVHDMouse modelResident gut microbesInflammationIntestinal microbiotaSignificant protectionGut floraHuman recipientsHuman floraInitial onsetGut microbesLongitudinal studyTransplantationMicrobiotaMice
2011
Genomic analysis identifies association of Fusobacterium with colorectal carcinoma
Kostic A, Gevers D, Pedamallu C, Michaud M, Duke F, Earl A, Ojesina A, Jung J, Bass A, Tabernero J, Baselga J, Liu C, Shivdasani R, Ogino S, Birren B, Huttenhower C, Garrett W, Meyerson M. Genomic analysis identifies association of Fusobacterium with colorectal carcinoma. Genome Research 2011, 22: 292-298. PMID: 22009990, PMCID: PMC3266036, DOI: 10.1101/gr.126573.111.Peer-Reviewed Original ResearchMeSH KeywordsColorectal NeoplasmsFusobacteriumGenome, BacterialHumansIntestine, LargeMetagenomePhylogenyRNA, Ribosomal, 16SSequence Analysis, DNAConceptsColorectal carcinomaColorectal carcinoma pathogenesisColorectal tumorsCarcinomaTumor microenvironmentTumor/normal pairsNonneoplastic cellsCancer cellsWhole genome sequencesPrecise roleTumorsMicrobiotaRDNA sequence analysisQuantitative PCRFurther investigationComplex communitiesGenome sequenceGenomic analysisSequence analysisFirmicutes phylumFusobacteriaNormal pairsCellsDiverse collectionDNA pairs