2019
Genetic associations and expression of extra-short isoforms of disrupted-in-schizophrenia 1 in a neurocognitive subgroup of schizophrenia
Liu C, Liu Y, Hwu H, Fann C, Yang U, Hsu P, Chang C, Chen W, Hwang T, Hsieh M, Liu C, Chien Y, Lin Y, Tsuang M. Genetic associations and expression of extra-short isoforms of disrupted-in-schizophrenia 1 in a neurocognitive subgroup of schizophrenia. Journal Of Human Genetics 2019, 64: 653-663. PMID: 30976040, DOI: 10.1038/s10038-019-0597-1.Peer-Reviewed Original ResearchMeSH KeywordsAllelesExonsFemaleGenetic Predisposition to DiseaseHumansMaleNerve Tissue ProteinsNeurocognitive DisordersPolymorphism, Single NucleotideProtein IsoformsRNA IsoformsSchizophreniaTaiwanConceptsDisrupted-in-schizophrenia 1Deficient sustained attentionSchizophrenia patientsContinuous Performance TestFrequency of AA genotypeRisk polymorphismsNeurocognitive subgroupsAssociated with schizophreniaEBV-transformed lymphocytesSustained attentionAA genotypeG alleleMRNA expression levelsA allelePatientsFamilial loadingIntron 4Genetic variantsSchizophreniaIsoform transcriptsGenetic associationSNPsExpression levelsIsoformsESV1
2016
Haplotypes of the D-Amino Acid Oxidase Gene Are Significantly Associated with Schizophrenia and Its Neurocognitive Deficits
Liu Y, Wang S, Hwu H, Fann C, Yang U, Yang W, Hsu P, Chang C, Wen C, Tsai-Wu J, Hwang T, Hsieh M, Liu C, Chien Y, Fang C, Faraone S, Tsuang M, Chen W, Liu C. Haplotypes of the D-Amino Acid Oxidase Gene Are Significantly Associated with Schizophrenia and Its Neurocognitive Deficits. PLOS ONE 2016, 11: e0150435. PMID: 26986737, PMCID: PMC4795637, DOI: 10.1371/journal.pone.0150435.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultD-Amino-Acid OxidaseFemaleGenetic Predisposition to DiseaseHaplotypesHumansMalePolymorphism, Single NucleotideSchizophreniaYoung AdultConceptsSingle-nucleotide polymorphismsAssociated with schizophreniaIntron 8Genomic regionsIntron 1Genetic variantsLarger patient samplesD-amino-acid oxidase geneNovel single‐nucleotide polymorphismsHaplotype association analysisSingle-locus analysisExecutive functionD-amino acid oxidaseFunctional genetic variantsSustained attentionNeurocognitive functionSchizophreniaEpstein-Barr virus-transformed lymphocytesMRNA expressionHaplotype blocksSingle-locusHaplotype distributionVirus-transformed lymphocytesHaplotype frequenciesAssociation analysis
2012
CC genotype donors for the interleukin‐28B single nucleotide polymorphism are associated with better outcomes in hepatitis C after liver transplant
Firpi R, Dong H, Clark V, Soldevila‐Pico C, Morelli G, Cabrera R, Norkina O, Shuster J, Nelson D, Liu C. CC genotype donors for the interleukin‐28B single nucleotide polymorphism are associated with better outcomes in hepatitis C after liver transplant. Liver International 2012, 33: 72-78. PMID: 23107586, PMCID: PMC3518691, DOI: 10.1111/liv.12013.Peer-Reviewed Original ResearchMeSH KeywordsAgedAntiviral AgentsBiopsyFemaleFloridaGenotypeHepatitis CHumansInterferonsInterleukinsKaplan-Meier EstimateLiver CirrhosisLiver TransplantationLogistic ModelsMaleMiddle AgedMultivariate AnalysisOdds RatioPolymorphism, Single NucleotideProportional Hazards ModelsRecurrenceRetrospective StudiesRisk AssessmentRisk FactorsTime FactorsTissue DonorsTreatment OutcomeConceptsSustained viral responseInterferon-based therapyLiver transplant patientsCC genotypeRecurrent HCVLiver transplantTransplant patientsIL-28B single nucleotide polymorphismInterleukin (IL) 28B single nucleotide polymorphismsAdult liver transplant patientsPost-transplant HCV recurrenceHepatitis C populationIL-28B genotypeIL-28B polymorphismsInterleukin 28B (IL28B) polymorphismsStrongest pretreatment predictorOverall clinical outcomeBetter treatment responseSingle nucleotide polymorphismsHCV recurrenceHCV patientsHCV therapyLiver transplantationHepatitis COverall survival
2009
NOD2 regulates hematopoietic cell function during graft-versus-host disease
Penack O, Smith O, Cunningham-Bussel A, Liu X, Rao U, Yim N, Na I, Holland A, Ghosh A, Lu S, Jenq R, Liu C, Murphy G, Brandl K, van den Brink M. NOD2 regulates hematopoietic cell function during graft-versus-host disease. Journal Of Experimental Medicine 2009, 206: 2101-2110. PMID: 19737867, PMCID: PMC2757869, DOI: 10.1084/jem.20090623.Peer-Reviewed Original ResearchConceptsAntigen-presenting cellsNOD2 deficiencyHost diseaseCrohn's diseaseExperimental allogeneic bone marrow transplantationAllogeneic bone marrow transplantationHost antigen-presenting cellsAllo-BMT recipientsDevelopment of GVHDExperimental colitis modelHematopoietic cellsHost hematopoietic cellsDonor T cellsIndependent risk factorBone marrow chimerasBone marrow transplantationChimeric recipientsIntestinal inflammationProinflammatory stateColitis modelMarrow transplantationNOD2 mutationsRisk factorsT cellsPaneth cells