2012
DNA Aptamer‐Mediated Cell Targeting
Xiong X, Liu H, Zhao Z, Altman M, Lopez‐Colon D, Yang C, Chang L, Liu C, Tan W. DNA Aptamer‐Mediated Cell Targeting. Angewandte Chemie International Edition 2012, 52: 1472-1476. PMID: 23233389, PMCID: PMC3793636, DOI: 10.1002/anie.201207063.Peer-Reviewed Original ResearchTargeted Delivery of Chemotherapy Agents Using a Liver Cancer-Specific Aptamer
Meng L, Yang L, Zhao X, Zhang L, Zhu H, Liu C, Tan W. Targeted Delivery of Chemotherapy Agents Using a Liver Cancer-Specific Aptamer. PLOS ONE 2012, 7: e33434. PMID: 22558072, PMCID: PMC3338807, DOI: 10.1371/journal.pone.0033434.Peer-Reviewed Original ResearchConceptsAptamer-drug conjugatesCancer-specific aptamersAntitumor agent doxorubicinDOX conjugatesIntercalation methodAptamerCell viability testTargeted deliveryConjugatesCancer cellsTarget proteinsAgent doxorubicinPotential candidateCell linesDOXEfficiency of chemotherapyLiver cancer cellsNonspecific uptakeTarget specificityAvailable aptamersCarcinoma cell linesChemotherapy agentsHepatocellular carcinoma cell linesHuman hepatocellular carcinoma cell linePromising method
2011
Molecular aptamers for drug delivery
Tan W, Wang H, Chen Y, Zhang X, Zhu H, Yang C, Yang R, Liu C. Molecular aptamers for drug delivery. Trends In Biotechnology 2011, 29: 634-640. PMID: 21821299, PMCID: PMC3218254, DOI: 10.1016/j.tibtech.2011.06.009.Peer-Reviewed Original ResearchConceptsVariety of nanomaterialsAptamer-mediated deliveryRapid tissue penetrationEasy chemical synthesisDNA micellesActive targetingGold nanorodsCarbon nanotubesMolecular aptamersChemical synthesisDrug deliveryDNA hydrogelsMolecular probesTissue penetrationAttractive moleculeAptamerPowerful technologyRecent progressWidespread applicationNanomaterialsTreatment of cancerNanorodsHigh affinityNanotubesDelivery
2010
DNA Aptamers as Molecular Probes for Colorectal Cancer Study
Sefah K, Meng L, Lopez-Colon D, Jimenez E, Liu C, Tan W. DNA Aptamers as Molecular Probes for Colorectal Cancer Study. PLOS ONE 2010, 5: e14269. PMID: 21170319, PMCID: PMC3000811, DOI: 10.1371/journal.pone.0014269.Peer-Reviewed Original ResearchConceptsColorectal cancerAppropriate therapeutic regimensCell-based systematic evolutionColorectal Cancer StudyMolecular featuresMultistep carcinogenic processCancer cell linesCell line DLD-1Therapeutic regimensNormal colon cellsPrognostic markerDifferent tumorsSpecific tumorsFlow cytometrySpecific biomarkersEarly disease detectionCarcinogenic processTumorsCancerSpecific markersCancer studiesColon cellsDLD-1Cell linesDisease development
2008
Identification of Liver Cancer-Specific Aptamers Using Whole Live Cells
Shangguan D, Meng L, Cao Z, Xiao Z, Fang X, Li Y, Cardona D, Witek R, Liu C, Tan W. Identification of Liver Cancer-Specific Aptamers Using Whole Live Cells. Analytical Chemistry 2008, 80: 721-728. PMID: 18177018, DOI: 10.1021/ac701962v.Peer-Reviewed Original ResearchConceptsLiver cancerLiver cancer cellsEarly diagnosisCell linesBALB/cJ miceCancer cellsSurgical resectionClinical outcomesLiver cell lineEffective treatmentMouse modelWhole live cellsDeadly cancerCurrent studyCancer-specific aptamersTumor selectionBasic mechanism studiesCancerMost cancersBNL CLCancer early diagnosisCell-SELEX methodNoncancer cell linesDiagnosisCancer recognition