The role of necroptosis in cancer biology and therapy
Gong Y, Fan Z, Luo G, Yang C, Huang Q, Fan K, Cheng H, Jin K, Ni Q, Yu X, Liu C. The role of necroptosis in cancer biology and therapy. Molecular Cancer 2019, 18: 100. PMID: 31122251, PMCID: PMC6532150, DOI: 10.1186/s12943-019-1029-8.Peer-Reviewed Original ResearchMeSH KeywordsDisease ProgressionGene Expression Regulation, NeoplasticGene Regulatory NetworksHumansNecroptosisNeoplasmsProtein KinasesReceptor-Interacting Protein Serine-Threonine KinasesTumor MicroenvironmentConceptsMixed lineage kinase domain-likeReceptor-interacting protein 1Apoptosis resistanceNecrotic cell death modalitiesCell deathMode of programmed cell deathCaspase-independent fashionCancer metastasisTumor progressionLineage kinase domain-likeCancer cellsInduce cancer cell deathCell death modalitiesCell death mechanismsCancer cell deathCancer immunity regulationImmunosuppressive tumor microenvironmentPrognosis of cancer patientsApoptotic pathwayAdaptive immune responsesDeath modalitiesPromote oncogenesisNecroptotic pathwayDeath mechanismsMetabolic signals