2024
Radioresistant Pulmonary Oligometastatic and Oligoprogressive Lesions From Nonlung Primaries: Impact of Histology and Dose-Fractionation on Local Control After Radiation Therapy
Verma N, Laird J, Moore N, Hayman T, Housri N, Peters G, Knowlton C, Jairam V, Campbell A, Park H. Radioresistant Pulmonary Oligometastatic and Oligoprogressive Lesions From Nonlung Primaries: Impact of Histology and Dose-Fractionation on Local Control After Radiation Therapy. Advances In Radiation Oncology 2024, 9: 101500. PMID: 38699671, PMCID: PMC11063223, DOI: 10.1016/j.adro.2024.101500.Peer-Reviewed Original ResearchLocal recurrence-free survivalNon-lung primaryAssociated with higher local recurrence-free survivalProgression-free survivalBiologically effective doseLocal controlRadioresistant metastasesOverall survivalPulmonary metastasesPrimary cancerColorectal carcinomaAssociated with superior local controlMultivariate analysisPatients treated with radiotherapyRisk of local recurrenceMedian follow-up timeMultivariable Cox proportional hazards regressionInferior local controlMedian total doseSuperior local controlAssociated with decreased riskImpact of histologyMetastasis-free survivalRecurrence-free survivalLocal failureDosimetric Factors Associated with Esophagitis Following Hypofractionated Radiotherapy to the Thorax
Sasse, Oh P, Saeed N, Yang D, Peters G, Hayman T, Housri N, Laird J, Campbell A, Knowlton C, Park H. Dosimetric Factors Associated with Esophagitis Following Hypofractionated Radiotherapy to the Thorax. International Journal Of Radiation Oncology • Biology • Physics 2024, 118: e7-e8. DOI: 10.1016/j.ijrobp.2023.10.059.Peer-Reviewed Original ResearchHypofractionated radiation therapyTotal patientsOverall survivalLocal controlUltra-central lung tumorsMultivariable logistic regression analysisSignificant differencesComparable local controlGrade 3 esophagitisRisk of gradeCases of gradeProbability of gradeLogistic regression analysisMATERIAL/METHODSMean esophagus doseSingle healthcare systemEsophagus DmaxPrimary endpointHypofractionated radiotherapyDosimetric factorsMultivariable analysisEsophagus doseThoracic tumorsDosimetric variablesClinical trials
2023
Interim Analysis of DD3: A Phase IB/II Trial of Dose-Deescalated 3-Fraction SBRT for Centrally Located Lung Cancer
Peters G, Cheng W, Boateng K, Knowlton C, Campbell A, Hayman T, Park H. Interim Analysis of DD3: A Phase IB/II Trial of Dose-Deescalated 3-Fraction SBRT for Centrally Located Lung Cancer. International Journal Of Radiation Oncology • Biology • Physics 2023, 117: e46-e47. DOI: 10.1016/j.ijrobp.2023.06.750.Peer-Reviewed Original ResearchStereotactic body radiation therapyPhase Ib/II trialCentral lung tumorsCancer-specific survivalProgression-free survivalLocal recurrenceLung tumorsInterim analysisII trialAdverse eventsOverall survivalDistant controlLocal controlGrade 2 adverse eventsUltra-central lung tumorsRisk dose constraintsRate of gradeSecondary lung tumorsCo-primary endpointsHigh toxicity ratesBiologically equivalent doseBody radiation therapyMATERIAL/METHODSRTOG 0236RTOG 0813Dose-Escalated vs. Conventional Hypofractionated Radiotherapy for Lung Cancer Patients in Predominantly Central Locations
Sasse A, Saeed N, Oh P, Housri N, Knowlton C, Hayman T, Peters G, Campbell A, Yang D, Park H. Dose-Escalated vs. Conventional Hypofractionated Radiotherapy for Lung Cancer Patients in Predominantly Central Locations. International Journal Of Radiation Oncology • Biology • Physics 2023, 117: e55. DOI: 10.1016/j.ijrobp.2023.06.768.Peer-Reviewed Original ResearchStereotactic body radiotherapyUltra-central tumoursHypofractionated radiation therapyHigh local controlOverall survivalGrade 3Local controlLung cancerNon-small cell lung cancerPromising local controlOutcomes of patientsEffective treatment regimenCell lung cancerHigher overall survivalLung cancer patientsMATERIAL/METHODSMedian ageHypofractionated radiotherapyTreatment regimenBody radiotherapyBaseline variablesCancer patientsTreatment optionsTumor locationChi-square analysis
2011
Radiotherapy in the treament of gastrointestinal stromal tumors
Knowlton C, Brady L, Heintzelman R. Radiotherapy in the treament of gastrointestinal stromal tumors. Rare Tumors 2011, 3: 35. PMID: 22355490, PMCID: PMC3282440, DOI: 10.4081/rt.2011.e35.Peer-Reviewed Original ResearchGastrointestinal stromal tumorsTreatment of gastrointestinal stromal tumorsStromal tumorsCase of metastatic gastrointestinal stromal tumourLong-term local controlMetastatic gastrointestinal stromal tumorsTreated with local radiotherapyUnresectable gastrointestinal stromal tumorsTyrosine kinase inhibitorsRate of metastasisStandard of careLocal radiotherapyResectable diseaseRadiosensitive tumorsRadiation therapySurgical resectionMesenchymal tumorsImatinib mesylatePalliative settingRadiotherapyKinase inhibitorsLocal controlTumorPatientsGastrointestinal tract