2024
A pilot study of p53 immunohistochemistry in atypical squamous lesions, using a vulvar scoring system
Niu N, Roy S, Ko C. A pilot study of p53 immunohistochemistry in atypical squamous lesions, using a vulvar scoring system. Journal Of Cutaneous Pathology 2024, 51: 379-386. PMID: 38317537, DOI: 10.1111/cup.14591.Peer-Reviewed Original ResearchCutaneous squamous cell carcinomaLow-risk cSCCAtypical squamous lesionsSquamous lesionsP53 positivityHigh-risk cutaneous squamous cell carcinomaP53 labelingDiagnosis of cutaneous squamous cell carcinomaPattern of p53 mutationsScoring systemBenign squamous lesionsHigh-risk featuresSquamous cell carcinomaImmunohistochemical scoring systemVulvar casesP53 immunostainingBenign mimicsP53 immunohistochemistryCell carcinomaP53 mutationsTP53 sequencingHistopathologic overlapPilot studyCutaneous casesLesions
2023
Squamous carcinogenesis: potential truncal mutations
Tang H, Seykora J, Ko C. Squamous carcinogenesis: potential truncal mutations. Human Pathology 2023, 140: 32-38. PMID: 37001739, DOI: 10.1016/j.humpath.2023.03.016.Peer-Reviewed Original Research
2014
Spontaneous tumour regression in keratoacanthomas is driven by Wnt/retinoic acid signalling cross-talk
Zito G, Saotome I, Liu Z, Ferro EG, Sun TY, Nguyen DX, Bilguvar K, Ko CJ, Greco V. Spontaneous tumour regression in keratoacanthomas is driven by Wnt/retinoic acid signalling cross-talk. Nature Communications 2014, 5: 3543. PMID: 24667544, PMCID: PMC3974217, DOI: 10.1038/ncomms4543.Peer-Reviewed Original ResearchConceptsTumor regressionRetinoic acidSquamous cell carcinomaSpontaneous tumor regressionMouse model systemCell carcinomaMalignant tumorsTherapeutic strategiesCutaneous keratoacanthomasKeratoacanthomaPhysiological mechanismsTumor growthHuman keratoacanthomaTumorsHair follicle regenerationCancer biologyFollicle regenerationRegressionDifferentiation programWntCarcinomaPathway
2013
Cutaneous squamous cell carcinomas of the lower extremity: A distinct subset of squamous cell carcinomas
Kim C, Ko CJ, Leffell DJ. Cutaneous squamous cell carcinomas of the lower extremity: A distinct subset of squamous cell carcinomas. Journal Of The American Academy Of Dermatology 2013, 70: 70-74. PMID: 24210370, DOI: 10.1016/j.jaad.2013.09.026.Peer-Reviewed Original ResearchConceptsCutaneous squamous cell carcinomaSquamous cell carcinomaLower extremitiesCell carcinomaClinical featuresIncidence of SCCPrevalence of SCCDistinct subsetsDistinctive clinical featuresNumber of patientsBasal cell carcinomaClinical outcomesSquamous cellsBiologic behaviorSame patientGeneral populationPatientsCarcinomaStudy periodAdditional studiesDefinitive conclusionsIncidenceExtremitiesOutcomesTreatment