mRNA-Binding Protein TIA-1 Reduces Cytokine Expression in Human Endometrial Stromal Cells and Is Down-Regulated in Ectopic Endometrium
Karalok HM, Aydin E, Saglam O, Torun A, Guzeloglu-Kayisli O, Lalioti MD, Kristiansson H, Duke CM, Choe G, Flannery C, Kallen CB, Seli E. mRNA-Binding Protein TIA-1 Reduces Cytokine Expression in Human Endometrial Stromal Cells and Is Down-Regulated in Ectopic Endometrium. The Journal Of Clinical Endocrinology & Metabolism 2014, 99: e2610-e2619. PMID: 25140393, PMCID: PMC4255110, DOI: 10.1210/jc.2013-3488.Peer-Reviewed Original ResearchConceptsHuman endometrial stromal cellsTNF-α expressionTIA-1 expressionEndometrial stromal cellsIL-6Pathogenesis of endometriosisMenstrual cycleTIA-1Endometrial tissueEctopic endometriumImmune factorsHistological scoresCultured human endometrial stromal cellsSteroid hormonesStromal cellsGrowth factorElevated IL-6Ectopic endometrial tissueNormal menstrual cycleEutopic endometrial tissuesGrowth factor expressionT-cell intracellular antigenEndometrial cytokinesEndometrial functionControl womenT-cell intracellular antigen (TIA-1) modulates the expression of immune factors in endometrial cells and may contribute to endometriosis
Duke C, Karalok H, Choe G, Flannery C, Kallen C, Seli E. T-cell intracellular antigen (TIA-1) modulates the expression of immune factors in endometrial cells and may contribute to endometriosis. Fertility And Sterility 2014, 102: e5. DOI: 10.1016/j.fertnstert.2014.07.024.Peer-Reviewed Original Research