2018
Insulin Regulates Glycogen Synthesis in Human Endometrial Glands Through Increased GYS2
Flannery CA, Choe GH, Cooke KM, Fleming AG, Radford CC, Kodaman PH, Jurczak MJ, Kibbey RG, Taylor HS. Insulin Regulates Glycogen Synthesis in Human Endometrial Glands Through Increased GYS2. The Journal Of Clinical Endocrinology & Metabolism 2018, 103: 2843-2850. PMID: 29726999, PMCID: PMC6276707, DOI: 10.1210/jc.2017-01759.Peer-Reviewed Original ResearchConceptsGlucose metabolismGlycogen synthesisSecretory phase endometriumEndometrial epithelial cellsHuman endometrial glandsGlycogen synthase kinase 3α/βSynthase kinase 3α/βMaternal obesityHealthy womenEndometrial glandsEarly pregnancyHuman endometriumGSK3α/βOutcome measurementsSuccessful implantationFetal developmentEndometriumCritical metabolic functionsInsulinGlycogen contentProgesteroneSustain embryo developmentEpithelial cellsInsulin receptorPotential role
2016
Development of a Quantitative PCR Assay for Detection of Human Insulin-Like Growth Factor Receptor and Insulin Receptor Isoforms
Flannery CA, Rowzee AM, Choe GH, Saleh FL, Radford CC, Taylor HS, Wood TL. Development of a Quantitative PCR Assay for Detection of Human Insulin-Like Growth Factor Receptor and Insulin Receptor Isoforms. Endocrinology 2016, 157: 1702-1708. PMID: 26862994, PMCID: PMC4816738, DOI: 10.1210/en.2015-1698.Peer-Reviewed Original ResearchConceptsSplice variantsInsulin-like growth factor (IGF) ligandsInsulin-like growth factor receptorGrowth factor ligandsSpecific molecular signaturesQuantitative PCR assaysGrowth factor receptorHigh homologyMRNA sequencesQuantitative RT-PCRIGF-1 receptorFactor ligandInsulin receptor isoformsCompetition assaysPrimer pairsRelative abundanceInsulin receptorMolecular signaturesCell typesDifferent tissuesIGF-1R mRNAFactor receptorExpression levelsGel electrophoresisReceptor isoforms