2018
Insulin Regulates Glycogen Synthesis in Human Endometrial Glands Through Increased GYS2
Flannery CA, Choe GH, Cooke KM, Fleming AG, Radford CC, Kodaman PH, Jurczak MJ, Kibbey RG, Taylor HS. Insulin Regulates Glycogen Synthesis in Human Endometrial Glands Through Increased GYS2. The Journal Of Clinical Endocrinology & Metabolism 2018, 103: 2843-2850. PMID: 29726999, PMCID: PMC6276707, DOI: 10.1210/jc.2017-01759.Peer-Reviewed Original ResearchConceptsGlucose metabolismGlycogen synthesisSecretory phase endometriumEndometrial epithelial cellsHuman endometrial glandsGlycogen synthase kinase 3α/βSynthase kinase 3α/βMaternal obesityHealthy womenEndometrial glandsEarly pregnancyHuman endometriumGSK3α/βOutcome measurementsSuccessful implantationFetal developmentEndometriumCritical metabolic functionsInsulinGlycogen contentProgesteroneSustain embryo developmentEpithelial cellsInsulin receptorPotential role
2014
The H19/let-7 double-negative feedback loop contributes to glucose metabolism in muscle cells
Gao Y, Wu F, Zhou J, Yan L, Jurczak MJ, Lee HY, Yang L, Mueller M, Zhou XB, Dandolo L, Szendroedi J, Roden M, Flannery C, Taylor H, Carmichael GG, Shulman GI, Huang Y. The H19/let-7 double-negative feedback loop contributes to glucose metabolism in muscle cells. Nucleic Acids Research 2014, 42: 13799-13811. PMID: 25399420, PMCID: PMC4267628, DOI: 10.1093/nar/gku1160.Peer-Reviewed Original ResearchConceptsDouble-negative feedback loopLet-7PI3K/Akt-dependent phosphorylationLet-7 targetsHuman genetic disordersAkt-dependent phosphorylationMuscle cellsInsulin-resistant rodentsSponge lncRNAsMolecular spongeH19 lncRNAFeedback loopGrowth controlDepletion resultsH19Impaired insulinLncRNAsTarget miRNAGlucose uptakeGenetic disordersBiogenesisCellsKSRPPhosphorylationMicroRNAsGlucose and Metformin Modulate Human First Trimester Trophoblast Function: a Model and Potential Therapy for Diabetes‐Associated Uteroplacental Insufficiency
Han CS, Herrin MA, Pitruzzello MC, Mulla MJ, Werner EF, Pettker CM, Flannery CA, Abrahams VM. Glucose and Metformin Modulate Human First Trimester Trophoblast Function: a Model and Potential Therapy for Diabetes‐Associated Uteroplacental Insufficiency. American Journal Of Reproductive Immunology 2014, 73: 362-371. PMID: 25394884, PMCID: PMC4356646, DOI: 10.1111/aji.12339.Peer-Reviewed Original ResearchMeSH KeywordsAngiogenesis Inducing AgentsAntigens, CDCarrier ProteinsCell LineCell MovementChemokine CCL5Chemokine CXCL1Diabetes ComplicationsDiabetes MellitusEndoglinFemaleGlucoseGranulocyte Colony-Stimulating FactorHumansInflammationInterleukinsMetforminNLR Family, Pyrin Domain-Containing 3 ProteinPlacentaPre-EclampsiaPregnancyPregnancy Trimester, FirstReceptors, Cell SurfaceTrophoblastsUterusVascular Endothelial Growth Factor Receptor-1ConceptsHuman first trimester trophoblast cell lineAnti-angiogenic factor sFlt-1First trimester trophoblast cell lineNalp3/ASC inflammasomeInflammatory cytokines/chemokinesFirst trimester trophoblast cellsGlucose-induced inflammationRisk of preeclampsiaCytokines/chemokinesAbsence of metforminIL-1β productionIL-1β secretionTrophoblast cell lineUteroplacental insufficiencyIL-1βIL-6SFlt-1Trophoblast functionsIL-8Pathogenic roleInflammatory responseASC inflammasomeSupernatant cytokinesPotential therapyExcess glucose
2009
Prevention of Hepatic Steatosis and Hepatic Insulin Resistance by Knockdown of cAMP Response Element-Binding Protein
Erion DM, Ignatova ID, Yonemitsu S, Nagai Y, Chatterjee P, Weismann D, Hsiao JJ, Zhang D, Iwasaki T, Stark R, Flannery C, Kahn M, Carmean CM, Yu XX, Murray SF, Bhanot S, Monia BP, Cline GW, Samuel VT, Shulman GI. Prevention of Hepatic Steatosis and Hepatic Insulin Resistance by Knockdown of cAMP Response Element-Binding Protein. Cell Metabolism 2009, 10: 499-506. PMID: 19945407, PMCID: PMC2799933, DOI: 10.1016/j.cmet.2009.10.007.Peer-Reviewed Original ResearchConceptsHepatic insulin resistanceNonalcoholic fatty liver diseaseCAMP response element-binding proteinInsulin resistanceResponse element-binding proteinASO treatmentElement-binding proteinCREB expressionType 2 diabetes mellitusOb/ob miceFatty liver diseaseHepatic triglyceride contentPlasma glucose concentrationFed rat modelAttractive therapeutic targetAntisense oligonucleotideDiabetes mellitusLiver diseaseZDF ratsHepatic steatosisOb micePostprandial hyperglycemiaPlasma cholesterolRat modelTriglyceride concentrations