2019
Endocrine regulation of MFS2 by branchless controls phosphate excretion and stone formation in Drosophila renal tubules
Rose E, Lee D, Xiao E, Zhao W, Wee M, Cohen J, Bergwitz C. Endocrine regulation of MFS2 by branchless controls phosphate excretion and stone formation in Drosophila renal tubules. Scientific Reports 2019, 9: 8798. PMID: 31217461, PMCID: PMC6584732, DOI: 10.1038/s41598-019-45269-x.Peer-Reviewed Original ResearchConceptsDrosophila renal tubulesFly life spanGenetic ablationRNAi-mediated knockdownInorganic phosphate (Pi) homeostasisHigh-Pi mediumPi transportersAdult fliesControl of FGF signalingHigher speciesPi mediumInduces expressionMFS2FGF signalingExcretion of PiPhosphate homeostasisDrosophilaFly longevityEndocrine regulationHormone fibroblast growth factor 23Renal tubulesHormonal controlPi transportFibroblast growth factor 23Genetic overexpression
2012
Dietary phosphate modifies lifespan in Drosophila
Bergwitz C. Dietary phosphate modifies lifespan in Drosophila. Nephrology Dialysis Transplantation 2012, 27: 3399-3406. PMID: 22942172, DOI: 10.1093/ndt/gfs362.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsImportant cellular processesNutrient-sensing pathwaysDrosophila melanogasterCellular processesLifespan extensionLarval developmentPhosphonoformic acidHuman disordersNormal fliesCellular uptakeSpecific pathwaysEffects of dietary phosphateDrosophilaReduced lifespanModel systemReduced cellular uptakeAdult lifespanLittle phosphateAbsorption of phosphatePathwayLifespanDietary phosphateTherapeutic approachesMelanogasterPowerful toolRoles of Major Facilitator Superfamily Transporters in Phosphate Response in Drosophila
Bergwitz C, Rasmussen MD, DeRobertis C, Wee MJ, Sinha S, Chen HH, Huang J, Perrimon N. Roles of Major Facilitator Superfamily Transporters in Phosphate Response in Drosophila. PLOS ONE 2012, 7: e31730. PMID: 22359624, PMCID: PMC3280997, DOI: 10.1371/journal.pone.0031730.Peer-Reviewed Original ResearchConceptsActivation of MAPKMajor Facilitator Superfamily (MFS) transporterDrosophila larval developmentRNAi-mediated knockdownMajor facilitator superfamily transportersPutative phosphate transportersDrosophila S2R+ cellsFacilitator superfamily transporterSodium-dependent fashionMetazoan speciesMetazoan cellsDrosophila cellsMammalian cellsPhosphate transporterLarval developmentMajor facilitatorPHO84S2R+ cellsFacilitator superfamilySuperfamily transportersMalpighian tubulesXenopus oocyte assayDrosophilaCellular effectsXenopus oocytes