2013
Genetic Determinants of Phosphate Response in Drosophila
Bergwitz C, Wee MJ, Sinha S, Huang J, DeRobertis C, Mensah LB, Cohen J, Friedman A, Kulkarni M, Hu Y, Vinayagam A, Schnall-Levin M, Berger B, Perkins LA, Mohr SE, Perrimon N. Genetic Determinants of Phosphate Response in Drosophila. PLOS ONE 2013, 8: e56753. PMID: 23520455, PMCID: PMC3592877, DOI: 10.1371/journal.pone.0056753.Peer-Reviewed Original ResearchConceptsLarval developmentGenome-wide RNAi screenDrosophila larval developmentGenetic determinantsImportant cellular processesNovel genetic determinantsAdult life spanLife spanExtracellular phosphate levelsD-rafRNAi-mediated inhibitionRNAi screenDrosophila melanogasterPhosphate responseCellular processesResponse to phosphateAdult fliesCandidate genesLive fliesMAPK activationAvailability of phosphateCellular responsesHigh phosphate mediumMalpighian tubulesReduced life span
2012
Dietary phosphate modifies lifespan in Drosophila
Bergwitz C. Dietary phosphate modifies lifespan in Drosophila. Nephrology Dialysis Transplantation 2012, 27: 3399-3406. PMID: 22942172, DOI: 10.1093/ndt/gfs362.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsImportant cellular processesNutrient-sensing pathwaysDrosophila melanogasterCellular processesLifespan extensionLarval developmentPhosphonoformic acidHuman disordersNormal fliesCellular uptakeSpecific pathwaysEffects of dietary phosphateDrosophilaReduced lifespanModel systemReduced cellular uptakeAdult lifespanLittle phosphateAbsorption of phosphatePathwayLifespanDietary phosphateTherapeutic approachesMelanogasterPowerful toolRoles of Major Facilitator Superfamily Transporters in Phosphate Response in Drosophila
Bergwitz C, Rasmussen MD, DeRobertis C, Wee MJ, Sinha S, Chen HH, Huang J, Perrimon N. Roles of Major Facilitator Superfamily Transporters in Phosphate Response in Drosophila. PLOS ONE 2012, 7: e31730. PMID: 22359624, PMCID: PMC3280997, DOI: 10.1371/journal.pone.0031730.Peer-Reviewed Original ResearchConceptsActivation of MAPKMajor Facilitator Superfamily (MFS) transporterDrosophila larval developmentRNAi-mediated knockdownMajor facilitator superfamily transportersPutative phosphate transportersDrosophila S2R+ cellsFacilitator superfamily transporterSodium-dependent fashionMetazoan speciesMetazoan cellsDrosophila cellsMammalian cellsPhosphate transporterLarval developmentMajor facilitatorPHO84S2R+ cellsFacilitator superfamilySuperfamily transportersMalpighian tubulesXenopus oocyte assayDrosophilaCellular effectsXenopus oocytes