2017
Response of Npt2a knockout mice to dietary calcium and phosphorus
Li Y, Caballero D, Ponsetto J, Chen A, Zhu C, Guo J, Demay M, Jüppner H, Bergwitz C. Response of Npt2a knockout mice to dietary calcium and phosphorus. PLOS ONE 2017, 12: e0176232. PMID: 28448530, PMCID: PMC5407772, DOI: 10.1371/journal.pone.0176232.Peer-Reviewed Original ResearchConceptsCompared to WT miceWT miceDietary calciumDietary phosphateCalcium x phosphorus productUrine phosphate levelsUrinary calcium excretionUrine anion gapDevelopment of novel therapiesWild-typeRenal stone diseaseWild-type miceNpt2a-knockout (KO) miceCalcium excretionFGF23 levelsNovel therapiesPreventing nephrolithiasisPlasma phosphateStone diseaseAnion gapAddition of calciumKnockout micePhosphorus productCalcium phosphate depositionHuman carriers
2010
Autoimmune Hypocalciuric Hypercalcemia Unresponsive to Glucocorticoid Therapy in a Patient with Blocking Autoantibodies against the Calcium-Sensing Receptor
Pallais JC, Kemp EH, Bergwitz C, Kantham L, Slovik DM, Weetman AP, Brown EM. Autoimmune Hypocalciuric Hypercalcemia Unresponsive to Glucocorticoid Therapy in a Patient with Blocking Autoantibodies against the Calcium-Sensing Receptor. The Journal Of Clinical Endocrinology & Metabolism 2010, 96: 672-680. PMID: 21159843, PMCID: PMC3047232, DOI: 10.1210/jc.2010-1739.Peer-Reviewed Original ResearchMeSH KeywordsAgedAntibodies, AntinuclearAntibodies, BlockingAutoantibodiesAutoimmune DiseasesCalciumDrug ResistanceExtracellular Signal-Regulated MAP KinasesFemaleGlucocorticoidsHumansHypercalcemiaImmunoglobulin EImmunoprecipitationInositol PhosphatesParathyroid HormonePhosphorylationReceptors, Calcium-SensingStimulation, ChemicalType C PhospholipasesConceptsAutoimmune hypocalciuric hypercalcemiaUrinary calcium excretionCalcium-sensing receptorGlucocorticoid therapyGlucocorticoid treatmentPTH levelsCalcium excretionAutoantibody titersAccumulation of inositol-1-phosphateTrial of glucocorticoid therapyHypocalciuric hypercalcemiaEffect of extracellular Ca(2Regulation of PTH secretionSerum PTH levelsElevated PTH levelsInositol-1-phosphate accumulationPTH-mediated hypercalcemiaIonized calcium concentrationAntibody-mediated inhibitionExtracellular Ca(2PTH secretionBlocking autoantibodiesAutoimmune disordersSerum totalHypercalcemia