2000
A versatile chondrogenic rat calvaria cell line R-tTA-24 that permits tetracycline-regulated gene expression
Bergwitz C, Wendlandt T, Pötter E, Glomb I, Gras K, von zur Mühlen A, Brabant G. A versatile chondrogenic rat calvaria cell line R-tTA-24 that permits tetracycline-regulated gene expression. Histochemistry And Cell Biology 2000, 113: 145-150. PMID: 10766267, DOI: 10.1007/s004180050017.Peer-Reviewed Original ResearchConceptsTetracycline-regulated gene expressionGene expressionTetracycline-regulated gene expression systemStable transfectionChondrogenic differentiationGene expression systemGene of interestBasis of phenotypeTetracycline transactivatorGenetic manipulationHygromycin selectionExpression systemCartilage-specific proteoglycansNeomycin selectionFlexible genetic manipulationLuciferase activityType II expressionCell linesAlcian blue stainingDifferentiationCollagen type II expressionTransfectionExpressionBlue stainingGenes
1999
The Cadherin-Catenin System: Implications for Growth and Differentiation of Endocrine Tissues
Pötter E, Bergwitz C, Brabant G. The Cadherin-Catenin System: Implications for Growth and Differentiation of Endocrine Tissues. Endocrine Reviews 1999, 20: 207-239. PMID: 10204118, DOI: 10.1210/edrv.20.2.0362.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsCadherin-catenin systemBeta-catenin/TCF4 complexComplex signal transduction pathwaysCell-cell adhesionNormal cell functionSignal transduction pathwaysLoss-of-functionRegulate cellular differentiationActivation of oncogenesEpigenetic mechanismsExtracellular modulatorsTransduction pathwaysTCF4 complexPosttranscriptional eventsCellular differentiationEndocrine tissuesIntracellular signalingGenetic mouse modelsProcess of tumorigenesisCadherin-cateninsSomatic gene mutationsPreservation of tissue integrityGene silencingCell adhesionC-Myc