2020
Recurrent Amplification of the Osmotic Stress Transcription Factor NFAT5 in Adrenocortical Carcinoma
Brown TC, Nicolson NG, Man J, Gibson CE, Stenman A, Juhlin CC, Korah R, Carling T. Recurrent Amplification of the Osmotic Stress Transcription Factor NFAT5 in Adrenocortical Carcinoma. Journal Of The Endocrine Society 2020, 4: bvaa060. PMID: 32587934, PMCID: PMC7304660, DOI: 10.1210/jendso/bvaa060.Peer-Reviewed Original Research
2019
Insulin-Like Growth Factor and SLC12A7 Dysregulation: A Novel Signaling Hallmark of Non-Functional Adrenocortical Carcinoma
Brown TC, Nicolson NG, Stenman A, Juhlin CC, Gibson CE, Callender GG, Korah R, Carling T. Insulin-Like Growth Factor and SLC12A7 Dysregulation: A Novel Signaling Hallmark of Non-Functional Adrenocortical Carcinoma. Journal Of The American College Of Surgeons 2019, 229: 305-315. PMID: 31034883, DOI: 10.1016/j.jamcollsurg.2019.04.018.Peer-Reviewed Original ResearchConceptsAdrenocortical carcinomaACC cell linesIGF1 overexpressionInsulin-like growth factorFunctional adrenocortical carcinomaIGF1 receptor activationRelationship of IGFWhole-exome sequencing analysisCancer Genome Atlas (TCGA) databaseEarly-stage tumorsCell linesGene amplificationCopy number variationsGrowth factor dysregulationAdrenal carcinogenesisCancer Genome AtlasExploratory cohortTumor characteristicsPolymerase chain reaction methodLarge tumorsIGF1R activationNCI-H295R.Chain reaction methodIGF treatmentQuantitative polymerase chain reaction method