2000
Small-molecule inhibitors of the cell cycle
Crews C, Mohan R. Small-molecule inhibitors of the cell cycle. Current Opinion In Chemical Biology 2000, 4: 47-53. PMID: 10679374, DOI: 10.1016/s1367-5931(99)00050-2.Peer-Reviewed Original ResearchConceptsSmall molecule inhibitorsCell cycleNovel cell cycle inhibitorsCyclin-dependent kinasesCell cycle progressionCell cycle inhibitorsCytoskeletal dynamicsAnti-mitotic agentsNovel chemotherapeuticsAttractive targetInhibitorsScreening technologiesRecent advancesKinaseGreater specificityCycleChemotherapeutics
1992
Erks: their fifteen minutes has arrived.
Crews CM, Alessandrini A, Erikson RL. Erks: their fifteen minutes has arrived. Molecular Cancer Research 1992, 3: 135-42. PMID: 1504018.Peer-Reviewed Original ResearchConceptsProtein kinaseCell cycleYeast cellsTyrosine kinase signalsERK protein kinasesSea star oocytesSpecific transcriptional factorsAmino acid residuesSpecific differentiation eventsG0-G1 transitionExtracellular signalsKinase signalsPhosphorylation signalsSignal transductionTranscriptional changesS6 kinaseRaf-1Differentiation eventsMitogenic signalsYeast enzymeGene productsMicrotubule reorganizationDownstream targetsTranscriptional factorsEGF receptor