2012
Exploring Biology with Small Organic Molecules
Aberle N, Crews C. Exploring Biology with Small Organic Molecules. 2012, 10-25. DOI: 10.1017/cbo9781139021500.004.Peer-Reviewed Original ResearchChemical geneticsSmall moleculesSmall organic moleculesFundamental biological processesProtein of interestGood target specificityOrganic moleculesSemisynthetic moleculesChemical genomicsBiological processesTarget specificityMoleculesGeneticsBiologyVast arrayActive ingredientsChemistryGenomicsCertain basic elementsHuman medicineTherapeuticsCompoundsPlantsProteinPhenotype
2010
Chemical Inducers of Targeted Protein Degradation*
Raina K, Crews CM. Chemical Inducers of Targeted Protein Degradation*. Journal Of Biological Chemistry 2010, 285: 11057-11060. PMID: 20147751, PMCID: PMC2856979, DOI: 10.1074/jbc.r109.078105.Peer-Reviewed Original ResearchConceptsProtein degradationTargeted Protein DegradationPost-translational levelSubsequent phenotypic analysisProtein functionSelective gene inactivationCellular proteinsCellular phenotypesRNA interferenceGene inactivationSpecific proteinsChemical inducersPhenotypic analysisChemical inductionGenetic mutationsProteinGenesDegradationMutationsPhenotypeDecreased productionMRNAInducerInactivationInduction