2021
Intercellular mitochondria transfer to macrophages regulates white adipose tissue homeostasis and is impaired in obesity
JR B, CB W, JR M, Y L, W Z, NP M, MN R, BT S, H M, MR M, BL H, DR B, A O, JW W, N R, X W, MR M, SA H, BS K, JG D, BH Z, MS D, HW V, AE G, SL T. Intercellular mitochondria transfer to macrophages regulates white adipose tissue homeostasis and is impaired in obesity. 2021 DOI: 10.1530/ey.18.11.10.Peer-Reviewed Original ResearchIntercellular mitochondria transferWhite adipose tissue homeostasisTissue homeostasisMitochondria transferAdipose tissue homeostasisHomeostasis
2020
Intercellular Mitochondria Transfer to Macrophages Regulates White Adipose Tissue Homeostasis and Is Impaired in Obesity
Brestoff JR, Wilen CB, Moley JR, Li Y, Zou W, Malvin NP, Rowen MN, Saunders BT, Ma H, Mack MR, Hykes BL, Balce DR, Orvedahl A, Williams JW, Rohatgi N, Wang X, McAllaster MR, Handley SA, Kim BS, Doench JG, Zinselmeyer BH, Diamond MS, Virgin HW, Gelman AE, Teitelbaum SL. Intercellular Mitochondria Transfer to Macrophages Regulates White Adipose Tissue Homeostasis and Is Impaired in Obesity. Cell Metabolism 2020, 33: 270-282.e8. PMID: 33278339, PMCID: PMC7858234, DOI: 10.1016/j.cmet.2020.11.008.Peer-Reviewed Original ResearchConceptsIntercellular mitochondria transferMitochondria transferMitochondria uptakeMetabolic homeostasisGenome-wide CRISPRWhite adipose tissue homeostasisWAT macrophagesDistinct macrophage subpopulationsKnockout screensTissue homeostasisHeparan sulfateAdipose tissue homeostasisWhite adipose tissueGenes EXT1HomeostasisImmunometabolic crosstalkMitochondriaAdipocytesMyeloid cellsMacrophage subpopulationsCellsVivoRecent studiesMacrophagesCRISPR