Lung Cancer Models Reveal Severe Acute Respiratory Syndrome Coronavirus 2–Induced Epithelial-to-Mesenchymal Transition Contributes to Coronavirus Disease 2019 Pathophysiology
Stewart CA, Gay CM, Ramkumar K, Cargill KR, Cardnell RJ, Nilsson MB, Heeke S, Park EM, Kundu ST, Diao L, Wang Q, Shen L, Xi Y, Zhang B, Della Corte CM, Fan Y, Kundu K, Gao B, Avila K, Pickering CR, Johnson FM, Zhang J, Kadara H, Minna JD, Gibbons DL, Wang J, Heymach JV, Byers LA. Lung Cancer Models Reveal Severe Acute Respiratory Syndrome Coronavirus 2–Induced Epithelial-to-Mesenchymal Transition Contributes to Coronavirus Disease 2019 Pathophysiology. Journal Of Thoracic Oncology 2021, 16: 1821-1839. PMID: 34274504, PMCID: PMC8282443, DOI: 10.1016/j.jtho.2021.07.002.Peer-Reviewed Original ResearchConceptsSevere acute respiratory syndrome coronavirus 2Acute respiratory syndrome coronavirus 2Respiratory syndrome coronavirus 2Syndrome coronavirus 2Coronavirus disease 2019SARS-CoV-2Coronavirus 2Disease 2019Coronavirus disease 2019 pathophysiologyMesenchymal transitionSARS-CoV-2 infectionSARS-CoV-2 pathogenesisSARS-CoV-2 receptorTyrosine kinase inhibitor resistanceEGFR tyrosine kinase inhibitor resistanceRegulation of ZEB1Lung cancer model systemsLung cancer modelKinase inhibitor resistanceCancer cell linesACE2 expressionRegulation of ACE2Respiratory virusesCancer model systemsHealthy patients