Genomic and Immunophenotypic Characteristics of Conjunctival Squamous Cell Carcinoma in a Sub-Saharan African Cohort Suggest a Role for Immune Checkpoint Inhibitors in Locally Advanced or Metastatic Patients
Esmaeli B, Gleber-Netto F, Sagiv O, Pickering C, Gross N, Ning J, Yeshi M, Mitku Y, Nagarajan P. Genomic and Immunophenotypic Characteristics of Conjunctival Squamous Cell Carcinoma in a Sub-Saharan African Cohort Suggest a Role for Immune Checkpoint Inhibitors in Locally Advanced or Metastatic Patients. JCO Global Oncology 2024, 10: 85-86. DOI: 10.1200/go-24-72000.Peer-Reviewed Original ResearchImmune checkpoint inhibitorsTumor mutational burdenConjunctival squamous cell carcinomaHigh-risk human papillomavirusSquamous cell carcinomaCheckpoint inhibitorsMetastatic patientsCell carcinomaImmunophenotypic characteristicsHigh risk human papillomavirus statusImmune checkpoint inhibitor therapyDensity of CD8+Sub-Saharan African cohortsPD-L1 expressionTumor-infiltrating lymphocytesCD3+ cellsTumors of patientsSub-Saharan AfricaWhole-exome sequencingSCC subtypePD-L1Thicker tumorsCD8+Clinical responseMutational burden