2024
Surgical and Endoscopic Management of Clinical T1b Esophageal Cancer
Ayoade O, Canavan M, De Santis W, Zhan P, Boffa D. Surgical and Endoscopic Management of Clinical T1b Esophageal Cancer. Journal Of Thoracic And Cardiovascular Surgery 2024 PMID: 38925509, DOI: 10.1016/j.jtcvs.2024.06.011.Peer-Reviewed Original ResearchEsophageal cancerTumor attributesEsophagectomy patientsEndoscopic treatmentAccelerated time failure modelsEndoscopic managementTumor size > 1 cmFactors associated with upstagingOccult lymph node metastasisAssociated with improved survivalAssociated with lymphovascular invasionEffect of esophagectomyT1b esophageal cancerTreatment naive patientsNational Cancer DatabaseWell-differentiated tumorsKaplan Meier analysisLymph node metastasisPoor tumor differentiationTime failure modelsNodal upstagingLymphovascular invasionOverall survivalEndoscopic patientsMeier analysis
2023
Assessment of a collaborative treatment model for trimodal management of esophageal cancer
Udelsman B, Ermer T, Ely S, Canavan M, Zhan P, Boffa D, Blasberg J. Assessment of a collaborative treatment model for trimodal management of esophageal cancer. Journal Of Thoracic Disease 2023, 15: 4668-4680. PMID: 37868899, PMCID: PMC10586936, DOI: 10.21037/jtd-23-346.Peer-Reviewed Original ResearchPathologic complete responseNational Cancer DatabaseGy of radiationEsophageal cancerCollaborative treatmentCollaborative treatment modelMultiagent chemotherapySingle institutionRate of pCRPatient travel burdenR0 resection rateTreatment modelTrimodality therapyTrimodality treatmentNeoadjuvant chemoradiotherapyNeoadjuvant therapyR0 resectionResection rateComplete responseMultivariable analysisTumor characteristicsCancer DatabaseMedian travel distancePatientsCollaborative Cohort
2022
Utilization and Outcomes of Radiation in Stage IV Esophageal Cancer
Zhan P, Canavan M, Ermer T, Pichert M, Li A, Maduka R, Kaminski M, Johung K, Boffa D. Utilization and Outcomes of Radiation in Stage IV Esophageal Cancer. JTO Clinical And Research Reports 2022, 3: 100429. PMID: 36483656, PMCID: PMC9722471, DOI: 10.1016/j.jtocrr.2022.100429.Peer-Reviewed Original ResearchStage IV esophageal cancerNational Cancer DatabaseEsophageal cancerCancer DatabaseRadiation doseSurvival advantageMedian total radiation dosePropensity score-matched pairsOutcome of radiationRetrospective cohort studyKaplan-Meier analysisTotal radiation doseAppropriate radiation dosePalliative regimensCohort studyMedian ageRadiation administrationSurvival associationsBetter survivalPatientsLocal controlCancerDosePalliationFurther studiesNonregional Lymph Nodes as the Only Metastatic Site in Stage IV Esophageal Cancer
Zhan P, Canavan M, Ermer T, Pichert M, Li A, Maduka R, Kaminski M, Boffa D. Nonregional Lymph Nodes as the Only Metastatic Site in Stage IV Esophageal Cancer. JTO Clinical And Research Reports 2022, 3: 100426. PMID: 36444359, PMCID: PMC9700291, DOI: 10.1016/j.jtocrr.2022.100426.Peer-Reviewed Original ResearchStage IV esophageal cancerNonregional lymph nodesEsophageal cancerSystemic metastasesLymph nodesMultiorgan metastasesOrgan metastasisSuperior survivalAcademic facility typesOnly metastatic siteNational Cancer DatabaseOutcomes of patientsPatients 18 yearsRetrospective cohort studyStage IV diseaseKaplan-Meier analysisSquamous cell carcinomaPropensity-matched sampleNonregional lymphCohort studyMetastatic involvementMetastatic sitesCell carcinomaCancer DatabaseCox model
2021
Chemoradiation as a nonsurgical treatment option for early-stage esophageal cancers: a retrospective cohort study
Pathak R, Canavan ME, Walters S, Salazar MC, Boffa DJ. Chemoradiation as a nonsurgical treatment option for early-stage esophageal cancers: a retrospective cohort study. Journal Of Thoracic Disease 2021, 13: 140-148. PMID: 33569194, PMCID: PMC7867841, DOI: 10.21037/jtd-20-1187.Peer-Reviewed Original ResearchEarly-stage esophageal cancerEsophageal cancerOverall survivalDefinitive non-surgical treatmentComorbidity-free patientsCT1/T2National Cancer DatabaseRetrospective cohort studyNon-surgical treatmentSubset of patientsGoals of careKaplan-Meier curvesNonsurgical treatment optionsKaplan-Meier estimatesInoperable patientsCohort studyNonsurgical approachCure rateTreatment optionsCancer patientsEndoscopic excisionCancer DatabaseTumor removalChemoradiationPatients
2020
Surgically Managed Signet Ring Cell Esophageal Carcinomas in the National Cancer Database
Sathe TS, Resio BJ, Hoag JR, Monsalve AF, Pathak R, Blasberg JD, Mase V, Dhanasopon A, Boffa DJ. Surgically Managed Signet Ring Cell Esophageal Carcinomas in the National Cancer Database. The Annals Of Thoracic Surgery 2020, 109: 1656-1662. PMID: 32109449, DOI: 10.1016/j.athoracsur.2020.01.021.Peer-Reviewed Original ResearchConceptsSignet ring cell adenocarcinomaNational Cancer DatabaseSRC tumorsACA patientsCancer DatabaseProportional hazards regression modelsCommon histologic variantRole of esophagectomyClinical stage IRole of surgeryHazards regression modelsHigh-grade tumorsSRC histologySRC patientsAdult patientsComplete resectionWorse prognosisCell adenocarcinomaEsophageal cancerEsophageal carcinomaHistologic variantsSuperior survivalEsophageal adenocarcinomaTreatment characteristicsClinical recommendations
2018
Survival outcomes from CALGB 80803 (Alliance): A randomized phase II trial of PET scan-directed combined modality therapy for esophageal cancer.
Goodman K, Hall N, Bekaii-Saab T, Ou F, Twohy E, Meyers M, Boffa D, Mitchell K, Perry K, Frankel W, Venook A, O'Reilly E, Ilson D. Survival outcomes from CALGB 80803 (Alliance): A randomized phase II trial of PET scan-directed combined modality therapy for esophageal cancer. Journal Of Clinical Oncology 2018, 36: 4012-4012. DOI: 10.1200/jco.2018.36.15_suppl.4012.Peer-Reviewed Original Research
2014
Learning Curve to Lymph Node Resection in Minimally Invasive Esophagectomy for Cancer
Dhamija A, Rosen J, Dhamija A, Rothberg BE, Kim A, Detterbeck F, Boffa D. Learning Curve to Lymph Node Resection in Minimally Invasive Esophagectomy for Cancer. Innovations Technology And Techniques In Cardiothoracic And Vascular Surgery 2014, 9: 286-291. DOI: 10.1177/155698451400900405.Peer-Reviewed Original ResearchLymph node yieldComplete resectionInvasive esophagectomyNode yieldSurgeon experienceMinimally Invasive EsophagectomyLymph node resectionSingle-surgeon seriesHigh-grade dysplasiaNode resectionComplete lymphadenectomyLymph nodesSurgical marginsOncologic efficacyRetrospective reviewNegative marginsOncologic aspectsEsophageal cancerInstitutional databaseInvasive approachLate subgroupsOpen approachMultivariate analysisResectionSafe alternative
2007
Celiac Lymph Nodes and Esophageal Cancer
Rice T, Boffa D. Celiac Lymph Nodes and Esophageal Cancer. 2007, 271-278. DOI: 10.1007/978-1-84628-474-8_33.Peer-Reviewed Original ResearchCeliac lymph nodesEsophageal cancerLymph nodesThoracic esophageal cancerAmerican Joint CommitteeGestational trophoblastic tumorsDistant metastatic sitesDistant metastasisMetastatic sitesStaging recommendationsTrophoblastic tumorJoint CommitteeDisease sitesCancerProstateTestisEsophagusMetastasisMelanomaTumorsRetinoblastomaSubclassification