2017
Mapping Extracellular pH of Gliomas in Presence of Superparamagnetic Nanoparticles: Towards Imaging the Distribution of Drug‐Containing Nanoparticles and Their Curative Effect on the Tumor Microenvironment
Maritim S, Coman D, Huang Y, Rao JU, Walsh JJ, Hyder F. Mapping Extracellular pH of Gliomas in Presence of Superparamagnetic Nanoparticles: Towards Imaging the Distribution of Drug‐Containing Nanoparticles and Their Curative Effect on the Tumor Microenvironment. Contrast Media & Molecular Imaging 2017, 2017: 3849373. PMID: 29362558, PMCID: PMC5736903, DOI: 10.1155/2017/3849373.Peer-Reviewed Original ResearchConceptsBrain microvasculatureCurative effectTherapeutic effectIntravenous injectionTherapeutic impactTumor typesD-NPsTumor microenvironmentSuperparamagnetic iron oxideTumor hallmarksGliomasDrug distributionInfusionMRI contrastHealing efficacyMRI readoutsMicrovasculatureDrugsExtracellular pHDrug-containing nanoparticlesTumor-targeted nanoparticlesSPIO NPsTumor boundaries
2014
Imaging the delivery of brain-penetrating PLGA nanoparticles in the brain using magnetic resonance
Strohbehn G, Coman D, Han L, Ragheb RR, Fahmy TM, Huttner AJ, Hyder F, Piepmeier JM, Saltzman WM, Zhou J. Imaging the delivery of brain-penetrating PLGA nanoparticles in the brain using magnetic resonance. Journal Of Neuro-Oncology 2014, 121: 441-449. PMID: 25403507, PMCID: PMC4323763, DOI: 10.1007/s11060-014-1658-0.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntineoplastic AgentsBrain NeoplasmsConvectionDrug Delivery SystemsFerric CompoundsGlioblastomaHumansImage Processing, Computer-AssistedLactic AcidMagnetic Resonance ImagingNanoparticlesNeuroimagingPolyglycolic AcidPolylactic Acid-Polyglycolic Acid CopolymerRatsRats, Sprague-DawleyConceptsBrain-penetrating nanoparticlesSuperparamagnetic iron oxideEfficient deliveryDrug-loaded nanoparticlesDistribution of nanoparticlesTransverse relaxivityPLGA nanoparticlesNanoparticlesConvection-enhanced deliveryDelivery platformFuture clinical applicationsUniversal tumor recurrenceClinical translationSignal attenuationDetection modalitiesIron oxideSame morphologyParticle distributionDeliveryGroundbreaking approachClinical applicationRelevant volumesRelaxivityTreatment of GBMOxide