2022
MR Imaging–Based In Vivo Macrophage Imaging to Monitor Immune Response after Radiofrequency Ablation of the Liver
Santana J, Petukhova-Greenstein A, Gross M, Hyder F, Pekurovsky V, Gottwald L, Boustani A, Walsh J, Kucukkaya A, Malpani R, Madoff D, Goldberg S, Ahmed M, Joshi N, Coman D, Chapiro J. MR Imaging–Based In Vivo Macrophage Imaging to Monitor Immune Response after Radiofrequency Ablation of the Liver. Journal Of Vascular And Interventional Radiology 2022, 34: 395-403.e5. PMID: 36423815, PMCID: PMC11042914, DOI: 10.1016/j.jvir.2022.11.013.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsContrast MediaImmunityLiverMacrophagesMagnetic Resonance ImagingMiceMice, Inbred C57BLRadiofrequency AblationConceptsImmune responseT1-weighted MRPrussian blue stainingRadiofrequency ablationRF ablationC57BL/6 wild-type miceMR imagingDose-escalation studyLocal immune responseMass cytometryWild-type miceRadiological-pathological correlationBlue stainingT1-weighted MR imagingHepatic radiofrequency ablationCD68 antibodyUntreated lobeVivo doseHepatic RF ablationVivo macrophagesMacrophagesMiceMR imaging scannerCoagulation areaCD68Methylated tetra‐amide derivatives of paramagnetic complexes for magnetic resonance biosensing with both BIRDS and CEST
Zakaria ABM, Huang Y, Coman D, Mishra SK, Mihailovic JM, Maritim S, Rojas‐Quijano F, Jurek P, Kiefer GE, Hyder F. Methylated tetra‐amide derivatives of paramagnetic complexes for magnetic resonance biosensing with both BIRDS and CEST. NMR In Biomedicine 2022, 35: e4687. PMID: 34970801, DOI: 10.1002/nbm.4687.Peer-Reviewed Original Research
2021
High‐resolution pH imaging using ratiometric chemical exchange saturation transfer combined with biosensor imaging of redundant deviation in shifts featuring paramagnetic DOTA‐tetraglycinate agents
Mihailovic JM, Huang Y, Walsh JJ, Khan MH, Mishra SK, Samuels S, Hyder F, Coman D. High‐resolution pH imaging using ratiometric chemical exchange saturation transfer combined with biosensor imaging of redundant deviation in shifts featuring paramagnetic DOTA‐tetraglycinate agents. NMR In Biomedicine 2021, 35: e4658. PMID: 34837412, DOI: 10.1002/nbm.4658.Peer-Reviewed Original Research
2020
Molecular MRI of the Immuno-Metabolic Interplay in a Rabbit Liver Tumor Model: A Biomarker for Resistance Mechanisms in Tumor-targeted Therapy?
Savic LJ, Doemel LA, Schobert IT, Montgomery RR, Joshi N, Walsh JJ, Santana J, Pekurovsky V, Zhang X, Lin M, Adam L, Boustani A, Duncan J, Leng L, Bucala RJ, Goldberg SN, Hyder F, Coman D, Chapiro J. Molecular MRI of the Immuno-Metabolic Interplay in a Rabbit Liver Tumor Model: A Biomarker for Resistance Mechanisms in Tumor-targeted Therapy? Radiology 2020, 296: 575-583. PMID: 32633675, PMCID: PMC7434651, DOI: 10.1148/radiol.2020200373.Peer-Reviewed Original ResearchConceptsImmuno-oncologic therapiesConventional transarterial chemoembolizationTransarterial chemoembolizationIntratumoral immune cell infiltrationMR spectroscopyRabbit liver tumor modelPrussian blue iron stainingAntigen-presenting immune cellsIntra-arterial infusionImmune cell infiltrationNew Zealand white rabbitsLiver tumor modelImmune cell exclusionLiver cancer modelContrast material administrationT2-weighted MRIZealand white rabbitsT2-weighted imagingResistance mechanismsImmunosuppressive tumorHLA-DRCell infiltrationImmune cellsImmunohistochemistry stainingRing enhancement
2019
Prognosticating brain tumor patient survival after laser thermotherapy: Comparison between neuroradiological reading and semi-quantitative analysis of MRI data
Hanna JM, Temares D, Hyder F, Rothman DL, Fulbright RK, Chiang VL, Coman D. Prognosticating brain tumor patient survival after laser thermotherapy: Comparison between neuroradiological reading and semi-quantitative analysis of MRI data. Magnetic Resonance Imaging 2019, 65: 45-54. PMID: 31675529, DOI: 10.1016/j.mri.2019.09.011.Peer-Reviewed Original Research
2017
Mapping Extracellular pH of Gliomas in Presence of Superparamagnetic Nanoparticles: Towards Imaging the Distribution of Drug‐Containing Nanoparticles and Their Curative Effect on the Tumor Microenvironment
Maritim S, Coman D, Huang Y, Rao JU, Walsh JJ, Hyder F. Mapping Extracellular pH of Gliomas in Presence of Superparamagnetic Nanoparticles: Towards Imaging the Distribution of Drug‐Containing Nanoparticles and Their Curative Effect on the Tumor Microenvironment. Contrast Media & Molecular Imaging 2017, 2017: 3849373. PMID: 29362558, PMCID: PMC5736903, DOI: 10.1155/2017/3849373.Peer-Reviewed Original ResearchConceptsBrain microvasculatureCurative effectTherapeutic effectIntravenous injectionTherapeutic impactTumor typesD-NPsTumor microenvironmentSuperparamagnetic iron oxideTumor hallmarksGliomasDrug distributionInfusionMRI contrastHealing efficacyMRI readoutsMicrovasculatureDrugsExtracellular pHDrug-containing nanoparticlesTumor-targeted nanoparticlesSPIO NPsTumor boundaries
2014
Characterization of a lanthanide complex encapsulated with MRI contrast agents into liposomes for biosensor imaging of redundant deviation in shifts (BIRDS)
Maritim S, Huang Y, Coman D, Hyder F. Characterization of a lanthanide complex encapsulated with MRI contrast agents into liposomes for biosensor imaging of redundant deviation in shifts (BIRDS). JBIC Journal Of Biological Inorganic Chemistry 2014, 19: 1385-1398. PMID: 25304046, PMCID: PMC4348029, DOI: 10.1007/s00775-014-1200-z.Peer-Reviewed Original ResearchConceptsLanthanide complexesMagnetic resonance imaging (MRI) probesParamagnetic lanthanide complexesT2 contrast agentsRedundant deviationMolecular imagingMRI contrast agentsNon-exchangeable protonsContrast agentsMRI contrastChemical shiftsMRI probesLiposomal encapsulation efficiencyParamagnetic environmentSignal amplificationEncapsulation efficiencyWater relaxationProbe environmentTransverse relaxation timeParamagnetic effectImaging probeHigh spatial resolutionParamagnetic agentsParamagnetic contrast agentRelaxation timeLanthanide ion (III) complexes of 1,4,7,10‐tetraazacyclododecane‐1,4,7,10‐tetraaminophosphonate for dual biosensing of pH with chemical exchange saturation transfer (CEST) and biosensor imaging of redundant deviation in shifts (BIRDS)
Huang Y, Coman D, Ali MM, Hyder F. Lanthanide ion (III) complexes of 1,4,7,10‐tetraazacyclododecane‐1,4,7,10‐tetraaminophosphonate for dual biosensing of pH with chemical exchange saturation transfer (CEST) and biosensor imaging of redundant deviation in shifts (BIRDS). Contrast Media & Molecular Imaging 2014, 10: 51-58. PMID: 24801742, PMCID: PMC4222994, DOI: 10.1002/cmmi.1604.Peer-Reviewed Original ResearchConceptsChemical exchange saturation transferLanthanide complexesExchangeable protonsProton resonancesPH imagingLanthanide ion complexesRedundant deviationChemical shift differencesChemical exchange saturation transfer contrastCEST contrastIon complexesChemical shiftsQuantitative pH imagingShift differencesSingle-proton resonancesChemical shift imaging methodsMagnetic resonanceCEST experimentsWater protonsNonexchangeable protonsParamagnetic effectSaturation transferBiosensorComplexesWater resonance