2020
A high‐throughput imaging platform to characterize extracellular pH in organotypic three‐dimensional in vitro models of liver cancer
Savic LJ, Schobert IT, Hamm CA, Adam LC, Hyder F, Coman D. A high‐throughput imaging platform to characterize extracellular pH in organotypic three‐dimensional in vitro models of liver cancer. NMR In Biomedicine 2020, 34: e4465. PMID: 33354836, DOI: 10.1002/nbm.4465.Peer-Reviewed Original ResearchConceptsLiver cancer modelLiver cancerHepatocellular carcinomaCancer modelNon-tumorous hepatocytesUnpaired t-testCell linesDose-dependent mannerHepatocyte cell lineTreatment responseTherapy resistanceMagnetic resonance spectroscopicT MR scannerPersonalized treatmentTumor metabolismCancerTumor pHMR resultsT-testCarcinomaViability assaysExtracellular pHMR scannerANOVA testTreatment
2019
Extracellular pH mapping of liver cancer on a clinical 3T MRI scanner
Coman D, Peters DC, Walsh JJ, Savic LJ, Huber S, Sinusas AJ, Lin M, Chapiro J, Constable RT, Rothman DL, Duncan JS, Hyder F. Extracellular pH mapping of liver cancer on a clinical 3T MRI scanner. Magnetic Resonance In Medicine 2019, 83: 1553-1564. PMID: 31691371, PMCID: PMC7244229, DOI: 10.1002/mrm.28035.Peer-Reviewed Original Research
2016
Imaging the intratumoral–peritumoral extracellular pH gradient of gliomas
Coman D, Huang Y, Rao JU, De Feyter HM, Rothman DL, Juchem C, Hyder F. Imaging the intratumoral–peritumoral extracellular pH gradient of gliomas. NMR In Biomedicine 2016, 29: 309-319. PMID: 26752688, PMCID: PMC4769673, DOI: 10.1002/nbm.3466.Peer-Reviewed Original ResearchConceptsRG2 tumorsTumor typesKi-67-positive cellsCancer therapeutic responseAcidic pHeTherapeutic responseRat brainPositive cellsSolid tumorsTumor cell invasionTumor borderTumorsPeritumoral regionNormal tissuesCell invasionTumor pHeP-MRSCancer imagingNeutral intracellularImagingPreclinical applicationsInfusionTherapy