2022
Methylated tetra‐amide derivatives of paramagnetic complexes for magnetic resonance biosensing with both BIRDS and CEST
Zakaria ABM, Huang Y, Coman D, Mishra SK, Mihailovic JM, Maritim S, Rojas‐Quijano F, Jurek P, Kiefer GE, Hyder F. Methylated tetra‐amide derivatives of paramagnetic complexes for magnetic resonance biosensing with both BIRDS and CEST. NMR In Biomedicine 2022, 35: e4687. PMID: 34970801, DOI: 10.1002/nbm.4687.Peer-Reviewed Original ResearchAmidesBiosensing TechniquesChelating AgentsContrast MediaMagnetic Resonance ImagingMagnetic Resonance SpectroscopyProtonsComparison of Lanthanide Macrocyclic Complexes as 23Na NMR Sensors
Khan MH, Mishra SK, Zakaria ABM, Mihailović J, Coman D, Hyder F. Comparison of Lanthanide Macrocyclic Complexes as 23Na NMR Sensors. Analytical Chemistry 2022, 94: 2536-2545. PMID: 35073049, DOI: 10.1021/acs.analchem.1c04432.Peer-Reviewed Original ResearchConceptsLanthanide macrocyclic complexesParamagnetic lanthanide ionsMagnetic resonance agentsLanthanide complexesMacrocyclic complexesMacrocyclic designDownfield shiftLanthanide ionsNa NMRBulk magnetic susceptibility effectsUnpaired electronChelating agentBiomedical applicationsNegative chargeNMR sensorSodium ionsTriazacyclononaneIonsComplexesBiological importanceMacrocyclicTmDOTPNaCationsGd
2019
Dynamic Thermal Mapping of Localized Therapeutic Hypothermia in the Brain
Walsh J, Huang Y, Simmons JW, Goodrich JA, McHugh B, Rothman DL, Elefteriades JA, Hyder F, Coman D. Dynamic Thermal Mapping of Localized Therapeutic Hypothermia in the Brain. Journal Of Neurotrauma 2019, 37: 55-65. PMID: 31311414, PMCID: PMC6922066, DOI: 10.1089/neu.2019.6485.Peer-Reviewed Original Research
2015
Distribution of temperature changes and neurovascular coupling in rat brain following 3,4‐methylenedioxymethamphetamine (MDMA, “ecstasy”) exposure
Coman D, Sanganahalli BG, Jiang L, Hyder F, Behar KL. Distribution of temperature changes and neurovascular coupling in rat brain following 3,4‐methylenedioxymethamphetamine (MDMA, “ecstasy”) exposure. NMR In Biomedicine 2015, 28: 1257-1266. PMID: 26286889, PMCID: PMC4573923, DOI: 10.1002/nbm.3375.Peer-Reviewed Original ResearchConceptsNeurovascular couplingBlood flowNeuronal activityNeural activityWhole-body hyperthermiaAbused psychostimulantMethylenedioxymethamphetamine (MDMA) exposureNeurovascular responseCortex temperatureMDMA effectsRat cortexRat brainBrain temperatureSubcortical regionsBrain regionsCortexSubcortexMDMA actionSkeletal muscleMonoaminergic stimulationBrainMDMACBFBody temperatureThermogenesis
2013
Mapping phosphorylation rate of fluoro-deoxy-glucose in rat brain by 19F chemical shift imaging
Coman D, Sanganahalli BG, Cheng D, McCarthy T, Rothman DL, Hyder F. Mapping phosphorylation rate of fluoro-deoxy-glucose in rat brain by 19F chemical shift imaging. Magnetic Resonance Imaging 2013, 32: 305-313. PMID: 24581725, PMCID: PMC3965601, DOI: 10.1016/j.mri.2013.10.015.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsAnimalsBrainFluorodeoxyglucose F18Glucose-6-PhosphateMagnetic Resonance ImagingMagnetic Resonance SpectroscopyMetabolic Clearance RateMolecular ImagingPhosphorylationPhosphotransferasesRadionuclide ImagingRadiopharmaceuticalsRatsRats, Inbred LewReproducibility of ResultsSensitivity and SpecificityTissue DistributionConceptsRat brainChemical shift imagingHalothane-anesthetized ratsMagnetic resonance spectroscopy studyTotal glucose metabolismMinimal side effectsMagnetic resonance imaging (MRI) measurementsFunctional magnetic resonance imaging (fMRI) measurementsFDG phosphorylationFMRI BOLD responsesCerebral physiologyForepaw stimulationShift imagingGlucose metabolismSide effectsBrain tissueFDGExtracted tissuesTumor pathophysiologyBrainMRS measurementsTissue componentsVivo detectionVivoD-glucose
2010
Brain temperature by Biosensor Imaging of Redundant Deviation in Shifts (BIRDS): comparison between TmDOTP5−and TmDOTMA−
Coman D, Trubel HK, Hyder F. Brain temperature by Biosensor Imaging of Redundant Deviation in Shifts (BIRDS): comparison between TmDOTP5−and TmDOTMA−. NMR In Biomedicine 2010, 23: 277-285. PMID: 19957287, PMCID: PMC2843767, DOI: 10.1002/nbm.1461.Peer-Reviewed Original Research
2009
Brain temperature and pH measured by 1H chemical shift imaging of a thulium agent
Coman D, Trubel HK, Rycyna RE, Hyder F. Brain temperature and pH measured by 1H chemical shift imaging of a thulium agent. NMR In Biomedicine 2009, 22: 229-239. PMID: 19130468, PMCID: PMC2735415, DOI: 10.1002/nbm.1312.Peer-Reviewed Original Research
2005
A Nuclear Magnetic Resonance Investigation of the Energetics of Basepair Opening Pathways in DNA
Coman D, Russu IM. A Nuclear Magnetic Resonance Investigation of the Energetics of Basepair Opening Pathways in DNA. Biophysical Journal 2005, 89: 3285-3292. PMID: 16126830, PMCID: PMC1366824, DOI: 10.1529/biophysj.105.065763.Peer-Reviewed Original ResearchConceptsOpening reactionFree energyNuclear magnetic resonance investigationFree energy relationshipsMagnetic resonance investigationNMR spectroscopySolvent protonsProton exchangeEnergy relationshipsTransition stateExchange catalystResonance investigationOpening pathwaysRate of exchangeEquilibrium constantsEnthalpy changeDNA duplexImino protonsReactionNeighboring basesProtonsDifferent temperaturesEnergeticsOpen stateCatalystBase Pair Opening in Three DNA-unwinding Elements*
Coman D, Russu IM. Base Pair Opening in Three DNA-unwinding Elements*. Journal Of Biological Chemistry 2005, 280: 20216-20221. PMID: 15784615, DOI: 10.1074/jbc.m502773200.Peer-Reviewed Original ResearchMeSH KeywordsAmmoniaBase PairingBase SequenceConserved SequenceDNA ReplicationDNA, BacterialEscherichia coliKineticsMagnetic Resonance SpectroscopyMolecular Sequence DataNucleic Acid ConformationProtonsConceptsDNA-unwinding elementsBase pairsDNA replicationIndividual base pairsBase sequenceEscherichia coli chromosomeOrigin of replicationTA base pairsSpecific base sequencesColi chromosomeBacterial genomesBacterial chromosomeDNA double helixDNA moleculesStrand separationFirst characterizationChromosomesStart pointBase pair openingDouble helixDNAReplicationSequenceNuclear magnetic resonance spectroscopyLong-range effects