1993
Inhibition of cervical carcinoma cell line proliferation by the introduction of a bovine papillomavirus regulatory gene
Hwang E, Riese D, Settleman J, Nilson L, Honig J, Flynn S, DiMaio D. Inhibition of cervical carcinoma cell line proliferation by the introduction of a bovine papillomavirus regulatory gene. Journal Of Virology 1993, 67: 3720-3729. PMID: 8389903, PMCID: PMC237735, DOI: 10.1128/jvi.67.7.3720-3729.1993.Peer-Reviewed Original ResearchConceptsBPV E2 proteinGene expressionCervical carcinoma cell linesRegulatory genesHPV gene expressionCarcinoma cell linesCell linesE2 proteinHeLa cellsConsequence of abrogationP53 tumor suppressor proteinHPV18 E6Tumor suppressor proteinE2 geneDestabilization of p53HT-3 cellsGrowth inhibitionBPV E2Simian virus 40Suppressor proteinEpithelial cell lineHuman papillomavirus E6Cell cycleGenesS phase
1988
Efficient transactivation and morphologic transformation by bovine papillomavirus genes expressed from a bovine papillomavirus/simian virus 40 recombinant virus.
Settleman J, DiMaio D. Efficient transactivation and morphologic transformation by bovine papillomavirus genes expressed from a bovine papillomavirus/simian virus 40 recombinant virus. Proceedings Of The National Academy Of Sciences Of The United States Of America 1988, 85: 9007-9011. PMID: 2848252, PMCID: PMC282651, DOI: 10.1073/pnas.85.23.9007.Peer-Reviewed Original ResearchConceptsBovine papillomavirus type 1 E2Simian virus 40 early regionTransactivation of genesCultured mammalian cellsHybrid viral genomesSimian virus 40 virionsMouse C127 cellsSimian virus 40 large tumor antigenBovine papillomavirus type 1Large tumor antigenPapillomavirus type 1E5 mutantsAcute cellular responseRegulatory genesMammalian cellsControl regionEfficient transactivationForeign genesReporter geneType 1 geneWild-type virusC127 cellsE5 geneTumorigenic transformationCellular responses