2001
Induced senescence in HeLa cervical carcinoma cells containing elevated telomerase activity and extended telomeres.
Goodwin E, DiMaio D. Induced senescence in HeLa cervical carcinoma cells containing elevated telomerase activity and extended telomeres. Molecular Cancer Research 2001, 12: 525-34. PMID: 11714633.Peer-Reviewed Original ResearchConceptsTumor suppressor pathwayHeLa cervical carcinoma cellsExtended telomeresReplicative senescenceHTERT geneSuppressor pathwayTelomerase activityGrowth arrestCervical carcinoma cellsRepression of telomeraseElevated telomerase activitySomatic human cellsNormal somatic human cellsShort telomeresGrowth-arrested stateSenescence-associated beta-galactosidase expressionHPV E6/E7 expressionGrowth-arrested cellsHeLa cell clonesProfound growth arrestRole of telomeraseE6/E7 genesBeta-galactosidase expressionErosion of telomeresCarcinoma cells
2000
Rapid induction of senescence in human cervical carcinoma cells
Goodwin E, Yang E, Lee C, Lee H, DiMaio D, Hwang E. Rapid induction of senescence in human cervical carcinoma cells. Proceedings Of The National Academy Of Sciences Of The United States Of America 2000, 97: 10978-10983. PMID: 11005870, PMCID: PMC27134, DOI: 10.1073/pnas.97.20.10978.Peer-Reviewed Original ResearchConceptsHuman papillomavirus E6Cervical carcinoma cellsCarcinoma cellsPapillomavirus E6Cervical carcinoma cell linesCell cycle regulatory proteinsViral oncogene expressionHuman cervical carcinoma cell lineCarcinoma cell linesCycle regulatory proteinsHuman cervical carcinoma cellsE7 oncogenesE7 proteinTransient alterationsCancer cellsOncogene expressionHuman cancersPhenotypic markersTelomerase activityCell linesRegulatory proteinsRapid inductionSenescence pathwaysCellsE2 regulatory protein