2009
Strategies to Circumvent Resistance to Apoptosis in Prostate Cancer Cells by Targeted Necrosis
Dinnen R, Petrylak D, Fine R. Strategies to Circumvent Resistance to Apoptosis in Prostate Cancer Cells by Targeted Necrosis. 2009, 327-346. DOI: 10.1007/978-1-4020-9597-9_14.Peer-Reviewed Original ResearchProstate cancer cellsCancer cellsCircumvent resistanceCancer linesHuman prostate cancer cellsProstate cancer cell linesMutant p53Prostate cancer linesNormal cellsCancer cell linesMechanism of cytotoxicityChemotherapy resistanceNecrosisDrug resistanceReactive oxygen speciesHigh levelsSelective killingApoptosisCell linesIntracellular generationNecrotic pathwaysP53Cell deathDeath pathwaysOxygen species
2007
Taxane-Based Chemotherapy for Prostate Cancer
Mohile S, Petrylak D. Taxane-Based Chemotherapy for Prostate Cancer. Contemporary Cancer Research 2007, 445-462. DOI: 10.1007/978-1-59745-224-3_23.Peer-Reviewed Original ResearchHormone-refractory prostate cancerTreatment of HRPCProstate cancerProgressive hormone-refractory prostate cancerCastrate testosterone levelsTaxane-based chemotherapyTaxane-based therapyProgression of diseaseTAX 327Adjuvant treatmentMetastatic diseaseSurvival benefitClinical outcomesDisease complicationsDismal prognosisSignificant morbidityAvailable therapiesEndothelin receptorsTargeted therapyTestosterone levelsTreatment liesChemotherapeutic agentsDrug resistanceTherapyMinimal toxicity