2015
Effect of Silodosin, an Alpha1A-Adrenoceptor Antagonist, on Ventral Prostatic Hyperplasia in the Spontaneously Hypertensive Rat
Shimizu S, Shimizu T, Tsounapi P, Higashi Y, Martin DT, Nakamura K, Honda M, Inoue K, Saito M. Effect of Silodosin, an Alpha1A-Adrenoceptor Antagonist, on Ventral Prostatic Hyperplasia in the Spontaneously Hypertensive Rat. PLOS ONE 2015, 10: e0133798. PMID: 26308715, PMCID: PMC4550428, DOI: 10.1371/journal.pone.0133798.Peer-Reviewed Original ResearchMeSH KeywordsActinsAdrenergic alpha-1 Receptor AntagonistsAnimalsChemokine CXCL1Fibroblast Growth Factor 2IndolesInterleukin-6MaleMalondialdehydeProstateProstatic HyperplasiaRatsRats, Inbred SHRReceptors, Adrenergic, alpha-1Regional Blood FlowTransforming Growth Factor beta1Tumor Necrosis Factor-alphaConceptsProstatic blood flowEffects of silodosinBasic fibroblast growth factorAlpha1A-adrenoceptor antagonistInterleukin-6Blood flowBlood pressureProstatic hyperplasiaHypertensive ratsTissue levelsWKY ratsΑ-SMATGF-β1Twelve-week-old male SHRsVentral prostateCytokine-induced neutrophil chemoattractant-1Selective alpha1A-adrenoceptor antagonistAlpha-smooth muscle actinGrowth factor beta 1Neutrophil chemoattractant-1Spontaneously Hypertensive RatsBenign prostatic enlargementBody weight ratioWistar-Kyoto ratsMorphological abnormalitiesProtective effect of hydroxyfasudil, a Rho kinase inhibitor, on ventral prostatic hyperplasia in the spontaneously hypertensive rat
Holmström F, Shimizu S, Shimizu T, Higashi Y, Martin DT, Honda M, Saito M. Protective effect of hydroxyfasudil, a Rho kinase inhibitor, on ventral prostatic hyperplasia in the spontaneously hypertensive rat. The Prostate 2015, 75: 1774-1782. PMID: 26286428, DOI: 10.1002/pros.23063.Peer-Reviewed Original ResearchConceptsVentral prostateBlood pressureHypertensive ratsWKY ratsInflammatory cytokinesProstatic hyperplasiaIL-6Growth factorΑ-SMATGF-β1Twelve-week-old SHRMorphological abnormalitiesROCK activityTail-cuff methodBody weight ratioWistar-Kyoto ratsHypertensive rat modelSmooth muscle contractionRho-kinase pathwayWeeks of ageRho-kinase inhibitorSmooth muscle differentiation markersInflammatory markersChronic treatmentProstate weight
2014
Blocking of the ATP sensitive potassium channel ameliorates the ischaemia‐reperfusion injury in the rat testis
Shimizu S, Oikawa R, Tsounapi P, Inoue K, Shimizu T, Tanaka K, Martin D, Honda M, Sejima T, Tomita S, Saito M. Blocking of the ATP sensitive potassium channel ameliorates the ischaemia‐reperfusion injury in the rat testis. Andrology 2014, 2: 458-465. PMID: 24604784, DOI: 10.1111/j.2047-2927.2014.00199.x.Peer-Reviewed Original ResearchConceptsTesticular IR injuryKATP channel blocker glibenclamideIschaemia-reperfusion injuryChannel blocker glibenclamideKATP channel blockerIR injuryKATP channel openerChannel openersTesticular ischaemiaBlocker glibenclamideChannel blockersEffective drugsSelective mitochondrial KATP channel blockerEight-week-old male SpragueKATP channel opener cromakalimATP-sensitive potassium channel openerSensitive potassium channel openerMitochondrial KATP channel blockerATP-sensitive potassium channelsAdministration of glibenclamideInduction of ischaemiaKATP channel opener diazoxideChannel opener cromakalimSensitive potassium channelsPotassium channel openers