2020
Scaffold association factor B (SAFB) is required for expression of prenyltransferases and RAS membrane association
Zhou M, Kuruvilla L, Shi X, Viviano S, Ahearn IM, Amendola CR, Su W, Badri S, Mahaffey J, Fehrenbacher N, Skok J, Schlessinger J, Turk BE, Calderwood DA, Philips MR. Scaffold association factor B (SAFB) is required for expression of prenyltransferases and RAS membrane association. Proceedings Of The National Academy Of Sciences Of The United States Of America 2020, 117: 31914-31922. PMID: 33257571, PMCID: PMC7749360, DOI: 10.1073/pnas.2005712117.Peer-Reviewed Original ResearchMeSH KeywordsAlkyl and Aryl TransferasesCell MembraneComputational BiologyCRISPR-Cas SystemsDatasets as TopicDimethylallyltranstransferaseGene Knockdown TechniquesHumansMatrix Attachment Region Binding ProteinsNeoplasmsNuclear Matrix-Associated ProteinsProtein PrenylationProtein SubunitsProto-Oncogene Proteins p21(ras)Receptors, EstrogenConceptsMembrane associationRAS membrane associationFarnesyltransferase inhibitorsPrenylation pathwayGenome-wide CRISPRGTP loadingAlternative prenylationMutant cellsNuclear proteinsKRAS membrane associationsRAS isoformsΑ-subunitGrowth inhibitionExpressionFactor BPathwayAnticancer therapyAlternative therapeutic strategiesPrenyltransferasesRASTherapeutic strategiesCRISPRFarnesyltransferaseMislocalizationPrenylation
2015
Regulation of integrin-mediated adhesions
Iwamoto DV, Calderwood DA. Regulation of integrin-mediated adhesions. Current Opinion In Cell Biology 2015, 36: 41-47. PMID: 26189062, PMCID: PMC4639423, DOI: 10.1016/j.ceb.2015.06.009.Peer-Reviewed Original ResearchConceptsIntegrin-mediated adhesionHeterodimeric transmembrane adhesion receptorsShort cytoplasmic tailTransmembrane adhesion receptorsSpecific intracellular proteinsClustering of integrinsMetazoan developmentActin cytoskeletonExtracellular ligandsCytoplasmic tailIntracellular traffickingExtracellular environmentIntracellular proteinsAdhesion receptorsAdhesive structuresIntegrin receptorsCell membraneRelay signalsIntegrinsEssential roleMechanical forcesCell attachmentAdhesionRecent advancesCytoskeleton
2014
The Talin Head Domain Reinforces Integrin-Mediated Adhesion by Promoting Adhesion Complex Stability and Clustering
Ellis SJ, Lostchuck E, Goult BT, Bouaouina M, Fairchild MJ, López-Ceballos P, Calderwood DA, Tanentzapf G. The Talin Head Domain Reinforces Integrin-Mediated Adhesion by Promoting Adhesion Complex Stability and Clustering. PLOS Genetics 2014, 10: e1004756. PMID: 25393120, PMCID: PMC4230843, DOI: 10.1371/journal.pgen.1004756.Peer-Reviewed Original Research
2012
Filamins in Mechanosensing and Signaling
Razinia Z, Mäkelä T, Ylänne J, Calderwood DA. Filamins in Mechanosensing and Signaling. Annual Review Of Biophysics 2012, 41: 227-246. PMID: 22404683, PMCID: PMC5508560, DOI: 10.1146/annurev-biophys-050511-102252.Peer-Reviewed Original ResearchConceptsPlasma membraneActin filamentsActin-binding proteinsExtracellular matrix connectionsCortical rigidityActin cytoskeletonCellular functionsCell cortexTranscription factorsTransmembrane receptorsAdhesion proteinsCell shapeFilaminIon channelsDiverse arrayFunctional evidenceEssential roleProteinMatrix connectionsPhysical forcesMembraneFilamentsCytoskeletalMechanosensingCytoskeleton
2003
Talin forges the links between integrins and actin
Calderwood DA, Ginsberg MH. Talin forges the links between integrins and actin. Nature Cell Biology 2003, 5: 694-696. PMID: 12894175, DOI: 10.1038/ncb0803-694.Peer-Reviewed Original ResearchMeSH KeywordsActinsAnimalsCell MembraneCytoskeletonIntegrinsProtein BindingProtein Structure, TertiarySignal TransductionTalinDomain-Specific Interactions of Talin with the Membrane-Proximal Region of the Integrin β3 Subunit †
Ulmer TS, Calderwood DA, Ginsberg MH, Campbell ID. Domain-Specific Interactions of Talin with the Membrane-Proximal Region of the Integrin β3 Subunit †. Biochemistry 2003, 42: 8307-8312. PMID: 12846579, DOI: 10.1021/bi034384s.Peer-Reviewed Original Research