2009
The E3 ubiquitin ligase specificity subunit ASB2β is a novel regulator of muscle differentiation that targets filamin B to proteasomal degradation
Bello NF, Lamsoul I, Heuzé ML, Métais A, Moreaux G, Calderwood DA, Duprez D, Moog-Lutz C, Lutz PG. The E3 ubiquitin ligase specificity subunit ASB2β is a novel regulator of muscle differentiation that targets filamin B to proteasomal degradation. Cell Death & Differentiation 2009, 16: 921-932. PMID: 19300455, PMCID: PMC2709956, DOI: 10.1038/cdd.2009.27.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAnimalsCarrier ProteinsCell DifferentiationCell LineChickensContractile ProteinsFilaminsGene Knockdown TechniquesHumansMiceMicrofilament ProteinsMyoblastsProteasome Endopeptidase ComplexRNA InterferenceRNA, MessengerSuppressor of Cytokine Signaling ProteinsUbiquitin-Protein LigasesConceptsFilamin BMuscle differentiationSpecificity subunitAnkyrin repeat-containing proteinActive E3 ubiquitin ligaseE3 ubiquitin ligase complexRepeat-containing proteinUbiquitin ligase complexE3 ubiquitin ligaseSuppressor of cytokineBox 2 geneLigase complexE3 ubiquitinUbiquitin ligaseProteasomal degradationMyoblast fusionNovel regulatorMuscle developmentKnockdown cellsProtein degradationMyogenic differentiationAdult tissuesC2C12 cellsMuscle contractile proteinsInduced differentiation
2003
Domain-Specific Interactions of Talin with the Membrane-Proximal Region of the Integrin β3 Subunit †
Ulmer TS, Calderwood DA, Ginsberg MH, Campbell ID. Domain-Specific Interactions of Talin with the Membrane-Proximal Region of the Integrin β3 Subunit †. Biochemistry 2003, 42: 8307-8312. PMID: 12846579, DOI: 10.1021/bi034384s.Peer-Reviewed Original ResearchStructural Determinants of Integrin Recognition by Talin
Garcı́a-Alvarez B, de Pereda JM, Calderwood DA, Ulmer TS, Critchley D, Campbell ID, Ginsberg MH, Liddington RC. Structural Determinants of Integrin Recognition by Talin. Molecular Cell 2003, 11: 49-58. PMID: 12535520, DOI: 10.1016/s1097-2765(02)00823-7.Peer-Reviewed Original ResearchConceptsBidirectional signal transductionFragment of talinIntegrin adhesion receptorsFERM domainIntegrin tailsCytoplasmic domainCytoplasmic proteinsSignal transductionIntegrin linkagesTransmembrane receptorsTalinMutational analysisAdhesion receptorsDomain recognitionCell interiorIntegrin recognitionStructural determinantsLigand interactionsNovel variantsStructural paradigmFragmentsTransductionReceptorsTailDomain