2014
Dynamin 2 regulation of integrin endocytosis, but not VEGF signaling, is crucial for developmental angiogenesis
Lee MY, Skoura A, Park EJ, Landskroner-Eiger S, Jozsef L, Luciano AK, Murata T, Pasula S, Dong Y, Bouaouina M, Calderwood DA, Ferguson SM, De Camilli P, Sessa WC. Dynamin 2 regulation of integrin endocytosis, but not VEGF signaling, is crucial for developmental angiogenesis. Development 2014, 141: 1465-1472. PMID: 24598168, PMCID: PMC3957370, DOI: 10.1242/dev.104539.Peer-Reviewed Original ResearchConceptsΒ1 integrinFocal adhesion sizeGrowth factor signalingVascular endothelial growth factor signalingEndocytic turnoverIntegrin endocytosisDynamin 2Adhesion sizeFactor signalingDevelopmental angiogenesisAngiogenic sproutingCell migrationCultured endothelial cellsMultiple integrinsInducible lossIntegrinsMorphogenesisActivation stateDNM2Endothelial cellsAngiogenesisVivoEndocytosisSurface levelSignaling
2006
Integrins in the Ovary
Monniaux D, Huet-Calderwood C, Bellego F, Fabre S, Monget P, Calderwood D. Integrins in the Ovary. Seminars In Reproductive Medicine 2006, 24: 251-261. PMID: 16944422, DOI: 10.1055/s-2006-948554.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsRole of integrinsSperm ADAMsActin cytoskeletonExtracellular matrix componentsIntegrin tailsMultiple signalingOocyte integrinsOvarian surface epithelium cellsIntegrin functionConformational changesExtracellular matrixIntegrinsCell proliferationMatrix componentsTumor developmentMajor receptorIntegrin expressionSurface epithelium cellsPossible involvementPotential roleFollicular cellsGranulosa cellsCellsFollicular basement membraneEpithelium cells
1995
Integrin α2 I-domain is a binding site for collagens
Tuckwell D, Calderwood D, Green L, Humphries M. Integrin α2 I-domain is a binding site for collagens. Journal Of Cell Science 1995, 108: 1629-1638. PMID: 7615681, DOI: 10.1242/jcs.108.4.1629.Peer-Reviewed Original ResearchConceptsAlpha 2 beta 1Alpha 1 beta 1I-domainIntegrin alpha 2 beta 1Beta 1N-terminal regionMajor cellular receptorAlpha 2 subunitIntegrins alpha 1 beta 1Complete receptorBacterial expressionAnti-functional antibodiesCollagen-binding domainA-domainInhibits cellAmino acidsCollagen specificityCellular receptorsXI collagenConcentration-dependent mannerVon Willebrand factorAlpha 1BindingWillebrand factorHomology